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latent transforming growth factor beta binding protein 3

Summary

Gene Symbol

Ltbp3

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

16998

PubChem

16998

Alliance of Genome Resources

MGI:1101355

Annotation

Keyword

Alternative splicing
Disulfide bond
EGF-like domain
Extracellular matrix
Glycoprotein
Growth factor binding
Reference proteome
Repeat
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q61810

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
positive regulation of mesenchymal stem cell differentiation	IEA ISO
bone mineralization	IMP	11790802
transforming growth factor beta receptor signaling pathway	IMP IPI ISO	12379497 7730318
chondrocyte differentiation	IMP	11790802
negative regulation of bone mineralization	IMP	11790802

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

transforming growth factor beta receptor signaling pathway

cellular developmental process [inference]

cell differentiation [inference]

chondrocyte differentiation

multicellular organismal process [inference]

tissue remodeling [inference]

bone remodeling

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

bone morphogenesis

anatomical structure development [inference]

tissue development [inference]

biomineral tissue development [inference]

bone mineralization

system development [inference]

skeletal system development

lung saccule development

cellular developmental process [inference]

cell differentiation [inference]

chondrocyte differentiation

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of stem cell proliferation [inference]

positive regulation of mesenchymal stem cell proliferation

positive regulation of cell differentiation [inference]

positive regulation of stem cell differentiation [inference]

positive regulation of mesenchymal stem cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of stem cell differentiation [inference]

positive regulation of mesenchymal stem cell differentiation

positive regulation of multicellular organismal process [inference]

positive regulation of bone resorption

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of chondrocyte differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of chondrocyte differentiation

negative regulation of cartilage development [inference]

negative regulation of chondrocyte differentiation

negative regulation of biomineral tissue development [inference]

negative regulation of bone mineralization

negative regulation of multicellular organismal process [inference]

negative regulation of ossification [inference]

negative regulation of bone mineralization

negative regulation of cartilage development [inference]

negative regulation of chondrocyte differentiation

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of chondrocyte differentiation [inference]

negative regulation of chondrocyte differentiation

negative regulation of cell differentiation [inference]

negative regulation of chondrocyte differentiation

positive regulation of cell differentiation [inference]

positive regulation of stem cell differentiation [inference]

positive regulation of mesenchymal stem cell differentiation

regulation of stem cell differentiation [inference]

positive regulation of stem cell differentiation [inference]

positive regulation of mesenchymal stem cell differentiation

regulation of mesenchymal stem cell differentiation [inference]

positive regulation of mesenchymal stem cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of chondrocyte differentiation

negative regulation of cartilage development [inference]

negative regulation of chondrocyte differentiation

negative regulation of biomineral tissue development [inference]

negative regulation of bone mineralization

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of stem cell differentiation [inference]

positive regulation of mesenchymal stem cell differentiation

regulation of multicellular organismal development [inference]

regulation of cartilage development [inference]

regulation of chondrocyte differentiation [inference]

negative regulation of chondrocyte differentiation

negative regulation of cartilage development [inference]

negative regulation of chondrocyte differentiation

regulation of biomineral tissue development [inference]

regulation of bone mineralization [inference]

negative regulation of bone mineralization

negative regulation of biomineral tissue development [inference]

negative regulation of bone mineralization

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

transforming growth factor beta receptor signaling pathway

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of stem cell proliferation [inference]

positive regulation of mesenchymal stem cell proliferation

regulation of stem cell proliferation [inference]

regulation of mesenchymal stem cell proliferation [inference]

positive regulation of mesenchymal stem cell proliferation

positive regulation of stem cell proliferation [inference]

positive regulation of mesenchymal stem cell proliferation

regulation of cell differentiation [inference]

regulation of chondrocyte differentiation [inference]

negative regulation of chondrocyte differentiation

negative regulation of cell differentiation [inference]

negative regulation of chondrocyte differentiation

positive regulation of cell differentiation [inference]

positive regulation of stem cell differentiation [inference]

positive regulation of mesenchymal stem cell differentiation

regulation of stem cell differentiation [inference]

positive regulation of stem cell differentiation [inference]

positive regulation of mesenchymal stem cell differentiation

regulation of mesenchymal stem cell differentiation [inference]

positive regulation of mesenchymal stem cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of stem cell proliferation [inference]

positive regulation of mesenchymal stem cell proliferation

positive regulation of cell differentiation [inference]

positive regulation of stem cell differentiation [inference]

positive regulation of mesenchymal stem cell differentiation

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of chondrocyte differentiation

regulation of multicellular organismal process [inference]

regulation of ossification [inference]

negative regulation of ossification [inference]

negative regulation of bone mineralization

regulation of bone mineralization [inference]

negative regulation of bone mineralization

regulation of tissue remodeling [inference]

regulation of bone remodeling [inference]

regulation of bone resorption [inference]

positive regulation of bone resorption

positive regulation of multicellular organismal process [inference]

positive regulation of bone resorption

negative regulation of multicellular organismal process [inference]

negative regulation of ossification [inference]

negative regulation of bone mineralization

negative regulation of cartilage development [inference]

negative regulation of chondrocyte differentiation

regulation of multicellular organismal development [inference]

regulation of cartilage development [inference]

regulation of chondrocyte differentiation [inference]

negative regulation of chondrocyte differentiation

negative regulation of cartilage development [inference]

negative regulation of chondrocyte differentiation

regulation of biomineral tissue development [inference]

regulation of bone mineralization [inference]

negative regulation of bone mineralization

negative regulation of biomineral tissue development [inference]

negative regulation of bone mineralization

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular matrix	ISA	7730318
collagen-containing extracellular matrix	IEA ISO
extracellular region	IDA	7730318

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

external encapsulating structure [inference]

extracellular matrix

collagen-containing extracellular matrix

Displaying **all 2** entries
GO Term	Evidence Code	PMID
calcium ion binding	IEA
transforming growth factor beta binding	IEA ISO

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

growth factor binding [inference]

transforming growth factor beta binding

cytokine binding [inference]

transforming growth factor beta binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

latent-transforming growth factor beta-binding protein 3

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
Golgi to vacuole transport
calcium ion binding
growth factor binding
protein targeting to vacuole

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0090143	brachyolmia-amelogenesis imperfecta syndrome	Alliance of Genome Resources
DOID:0111727	geleophysic dysplasia 3	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 94 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Mustela putorius furo	101682070		MUSPF05730
Heterocephalus glaber	101721853	10181_0:00229b
Mesocricetus auratus	101827539	10036_0:0004c0
Chrysemys picta bellii	101950349		CHRPI09010
Ictidomys tridecemlineatus	101969795	43179_0:001232	ICTTR16050
Microtus ochrogaster	101989086	79684_0:0018eb
Chinchilla lanigera	102008953	34839_0:0016df	CHILA07077
Capra hircus	102172418		CAPHI19523
Xiphophorus maculatus	102217854		XIPMA03066
Neolamprologus brichardi	102793879		NEOBR22350