GlyCosmos Portal

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GO Term	Evidence Code	PMID
8-oxo-7,8-dihydroguanine DNA N-glycosylase activity	IBA
DNA binding	IEA
oxidized purine DNA binding	IBA
adenine/guanine mispair binding	IBA
MutSalpha complex binding	IEA ISO

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds

hydrolase activity, hydrolyzing N-glycosyl compounds [inference]

DNA N-glycosylase activity

mismatch base pair DNA N-glycosylase activity [inference]

purine-specific mismatch base pair DNA N-glycosylase activity

oxidized base lesion DNA N-glycosylase activity [inference]

oxidized purine nucleobase lesion DNA N-glycosylase activity [inference]

8-oxo-7,8-dihydroguanine DNA N-glycosylase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA N-glycosylase activity

mismatch base pair DNA N-glycosylase activity [inference]

purine-specific mismatch base pair DNA N-glycosylase activity

oxidized base lesion DNA N-glycosylase activity [inference]

oxidized purine nucleobase lesion DNA N-glycosylase activity [inference]

8-oxo-7,8-dihydroguanine DNA N-glycosylase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding [inference]

mismatch repair complex binding [inference]

metal cluster binding [inference]

iron-sulfur cluster binding [inference]

4 iron, 4 sulfur cluster binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

damaged DNA binding [inference]

oxidized DNA binding [inference]

oxidized purine DNA binding

double-stranded DNA binding [inference]

mismatched DNA binding [inference]

adenine/guanine mispair binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

DNA glycosylase

Functional Category

F: Nucleotide transport and metabolism
L: Replication, recombination and repair
T: Signal transduction mechanisms
V: Defense mechanisms

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Gene Ontology
4 iron, 4 sulfur cluster binding
8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
DNA repair
adenine/guanine mispair binding
base-excision repair
catalytic activity
hydrolase activity, acting on glycosyl bonds
hydrolase activity
iron-sulfur cluster binding
metal ion binding

Displaying **all 9** entries
InterPro
Adenine DNA glycosylase, C-terminal
Adenine/Thymine-DNA glycosylase
DNA glycosylase
Endonuclease III-like, conserved site-2
Endonuclease III-like, iron-sulphur cluster loop motif
Helix-hairpin-helix, base-excision DNA repair, C-terminal
HhH-GPD domain
NUDIX hydrolase domain
NUDIX hydrolase-like domain superfamily

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0050424	familial adenomatous polyposis	Alliance of Genome Resources
DOID:0080410	familial adenomatous polyposis 2	Alliance of Genome Resources
DOID:10534	stomach cancer	Alliance of Genome Resources
DOID:5517	stomach carcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **101** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	4595		HGNC:7527	HUMAN49548
Mus musculus	70603	10090_1:001427	MGI:1917853	MOUSE41009
Pan troglodytes	456539			PANTR20933
Bos taurus	513051			BOVIN27071
Danio rerio	558403		ZFIN:ZDB-GENE-081104-193	DANRE43404
Macaca mulatta	705651			MACMU25552
Xenopus tropicalis	780292		Xenbase:XB-GENE-998137
Taeniopygia guttata	100226093			TAEGU29077
Oryctolagus cuniculus	100344165			RABIT03973
Callithrix jacchus	100397524			CALJA41663