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MIRAGE

serine incorporator 5

Summary

Gene Symbol

Serinc5

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

170907

PubChem

170907

Alliance of Genome Resources

RGD:621571

Annotation

Keyword

Alternative splicing
Antiviral defense
Cell membrane
Glycoprotein
Innate immunity
Phospholipid biosynthesis
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q63175	Developmentally regulated protein TPO1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 17 in total

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GO Term	Evidence Code	PMID
plasma membrane phospholipid scrambling	ISO
plasma membrane phospholipid scrambling	IEA
myelination	ISO
myelination	IEP	9326262
myelination	IEA

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

innate immune response

antiviral innate immune response

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

phosphatidylserine metabolic process

sphingolipid metabolic process

biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

phosphatidylserine metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process

phospholipid biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process

phospholipid biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process

phospholipid biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process

phospholipid biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process

phospholipid biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process

phospholipid biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

phosphatidylserine metabolic process

sphingolipid metabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

cellular process [inference]

ensheathment of neurons [inference]

axon ensheathment [inference]

myelination

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

phosphatidylserine metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process

phospholipid biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process

phospholipid biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process

phospholipid biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

plasma membrane organization [inference]

plasma membrane phospholipid scrambling

regulation of membrane lipid distribution [inference]

lipid translocation [inference]

phospholipid translocation [inference]

plasma membrane phospholipid scrambling

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus [inference]

detection of virus

defense response to virus

antiviral innate immune response

defense response to other organism [inference]

innate immune response

antiviral innate immune response

defense response to symbiont [inference]

defense response to virus

antiviral innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response

antiviral innate immune response

defense response to symbiont [inference]

defense response to virus

antiviral innate immune response

immune response [inference]

innate immune response

antiviral innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

detection of virus

defense response to virus

antiviral innate immune response

defense response to other organism [inference]

innate immune response

antiviral innate immune response

defense response to symbiont [inference]

defense response to virus

antiviral innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

detection of virus

defense response to virus

antiviral innate immune response

defense response to other organism [inference]

innate immune response

antiviral innate immune response

defense response to symbiont [inference]

defense response to virus

antiviral innate immune response

localization [inference]

establishment of localization [inference]

transport [inference]

organic substance transport [inference]

lipid transport [inference]

phospholipid transport [inference]

phospholipid translocation [inference]

plasma membrane phospholipid scrambling

lipid translocation [inference]

phospholipid translocation [inference]

plasma membrane phospholipid scrambling

organophosphate ester transport [inference]

phospholipid transport [inference]

phospholipid translocation [inference]

plasma membrane phospholipid scrambling

biological regulation [inference]

regulation of biological quality [inference]

regulation of membrane lipid distribution [inference]

lipid translocation [inference]

phospholipid translocation [inference]

plasma membrane phospholipid scrambling

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of transferase activity [inference]

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of transferase activity [inference]

regulation of transferase activity [inference]

positive regulation of transferase activity [inference]

regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity [inference]

positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity

regulation of serine C-palmitoyltransferase activity [inference]

positive regulation of serine C-palmitoyltransferase activity

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
Golgi apparatus	ISO
Golgi apparatus	IEA
centrosome	ISO
centrosome	IEA
cytosol	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

microtubule organizing center [inference]

centrosome

cytosol

plasma membrane

myelin sheath

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle

Golgi apparatus

Displaying **all 5** entries
GO Term	Evidence Code	PMID
acetyltransferase activator activity	IDA	16120614
phospholipid scramblase activity	ISS
phospholipid scramblase activity	ISO
phospholipid scramblase activity	IEA
protein-macromolecule adaptor activity	ISS

GO Hierarchy

molecular function

transporter activity [inference]

lipid transporter activity [inference]

phospholipid transporter activity [inference]

phospholipid scramblase activity

intramembrane lipid transporter activity [inference]

phospholipid scramblase activity

molecular adaptor activity [inference]

protein-macromolecule adaptor activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

acetyltransferase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

acetyltransferase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

serine incorporator

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
InterPro
Serine incorporator/TMS membrane protein

Ortholog

Displaying entries **1 - 10** of 87 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	10955	SGD:S000002512
Saccharomyces cerevisiae S288C	26943	SGD:S000002512
Saccharomyces cerevisiae S288C	57515	SGD:S000002512
Xenopus tropicalis	170907	Xenbase:XB-GENE-1008360
Xenopus tropicalis	179093	Xenbase:XB-GENE-1008360
Mus musculus	218442	Xenbase:XB-GENE-1008360	MOUSE11739
Homo sapiens	256987	Xenbase:XB-GENE-1008360	HUMAN79854
Danio rerio	406835	Xenbase:XB-GENE-1008360	DANRE35707
Pan troglodytes	461778		PANTR35204
Canis lupus familiaris	479168		CANLF11918

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Last updated: December 8, 2025