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leucyl and cystinyl aminopeptidase

Summary

Gene Symbol

Lnpep

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

171105

PubChem

171105

Alliance of Genome Resources

RGD:621752

Annotation

Keyword

Acetylation
Aminopeptidase
Cell membrane
Direct protein sequencing
Glycoprotein
Metal-binding
Metalloprotease
Phosphoprotein
Reference proteome
Signal-anchor
Transmembrane helix
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6KB65
P97629	GP160 Insulin-regulated membrane aminopeptidase Insulin-responsive aminopeptidase Oxytocinase Placental leucine aminopeptidase Vesicle protein of 165 kDa

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
proteolysis	IBA
proteolysis	IEA
regulation of blood pressure	IBA
response to hormone	IDA	12709058
neuropeptide catabolic process	IMP	16771832

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

peptide catabolic process

neuropeptide catabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide catabolic process

neuropeptide catabolic process

protein metabolic process [inference]

organonitrogen compound catabolic process [inference]

protein catabolic process

peptide catabolic process

neuropeptide catabolic process

catabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process

neuropeptide catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

peptide catabolic process

neuropeptide catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process

neuropeptide catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein metabolic process [inference]

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide catabolic process

neuropeptide catabolic process

protein metabolic process [inference]

organonitrogen compound catabolic process [inference]

protein catabolic process

peptide catabolic process

neuropeptide catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

peptide catabolic process

neuropeptide catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process

neuropeptide catabolic process

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone

response to chemical [inference]

response to organic substance [inference]

response to hormone

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

negative regulation of cold-induced thermogenesis

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity [inference]

regulation of long-term neuronal synaptic plasticity

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of cold-induced thermogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of cold-induced thermogenesis

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity [inference]

regulation of long-term neuronal synaptic plasticity

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

negative regulation of cold-induced thermogenesis

regulation of biological quality [inference]

regulation of blood pressure

positive regulation of blood pressure

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity [inference]

regulation of long-term neuronal synaptic plasticity

Displaying entries **16 - 17** of 17 in total

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GO Term	Evidence Code	PMID
perinuclear region of cytoplasm	IDA	9271094
perinuclear region of cytoplasm	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

insulin-responsive compartment

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

insulin-responsive compartment

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

insulin-responsive compartment

cell body [inference]

neuronal cell body

perinuclear region of cytoplasm

Displaying entries **6 - 9** of 9 in total

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GO Term	Evidence Code	PMID
zinc ion binding	IBA
zinc ion binding	IEA
peptide binding	IBA
metalloaminopeptidase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

metallopeptidase activity

metalloexopeptidase activity [inference]

metalloaminopeptidase activity

exopeptidase activity [inference]

aminopeptidase activity

metalloaminopeptidase activity

metalloexopeptidase activity [inference]

metalloaminopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

metallopeptidase activity

metalloexopeptidase activity [inference]

metalloaminopeptidase activity

exopeptidase activity [inference]

aminopeptidase activity

metalloaminopeptidase activity

metalloexopeptidase activity [inference]

metalloaminopeptidase activity

binding [inference]

amide binding [inference]

peptide binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Aminopeptidase

Functional Category

E: Amino acid transport and metabolism
K: Transcription
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 9** entries
Gene Ontology
aminopeptidase activity
hydrolase activity
metal ion binding
metalloaminopeptidase activity
metallopeptidase activity
peptide binding
peptide catabolic process
proteolysis
zinc ion binding

Displaying **all 7** entries
InterPro
Aminopeptidase N-like , N-terminal domain superfamliy
Aminopeptidase N-like , N-terminal domain
Aminopeptidase N-type
ERAP1-like C-terminal domain
Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
Peptidase M1, membrane alanine aminopeptidase
Peptidase M4/M1, CTD superfamily

Alliance of Genome Resources

Expression

Displaying **all 5** entries
Location	References
cell surface	PMID:16967782
perinuclear region of cytoplasm	PMID:9271094
vesicle	PMID:12709058
neuronal cell body	PMID:15906313
insulin-responsive compartment	PMID:7559527 PMID:9271094

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 91 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	290	SGD:S000001399
Saccharomyces cerevisiae S288C	2028	SGD:S000001399
Homo sapiens	4012	Xenbase:XB-GENE-950921	HUMAN80163
Saccharomyces cerevisiae S288C	13809	SGD:S000001399
Saccharomyces cerevisiae S288C	16790	SGD:S000001399
Saccharomyces cerevisiae S288C	29953	SGD:S000001399
Saccharomyces cerevisiae S288C	51752	SGD:S000001399
Saccharomyces cerevisiae S288C	64017	SGD:S000001399
Saccharomyces cerevisiae S288C	64167	SGD:S000001399
Saccharomyces cerevisiae S288C	80898	SGD:S000001399

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UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements