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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Neprilysin-11
Summary
- Gene Symbol
-
- nep-11
- Organism
- Caenorhabditis elegans
Annotation
- Keyword
-
- Alternative splicing
- Cell membrane
- Disulfide bond
- Glycoprotein
- Metal-binding
- Metalloprotease
- Reference proteome
- Signal-anchor
- Transmembrane helix
- Zinc
- Proteins
| UniProt | Protein Name |
|---|---|
| O16796 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| proteolysis | ||
| protein processing |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| plasma membrane |
| GO Term | Evidence Code | PMID |
|---|---|---|
| metal ion binding | ||
| metalloendopeptidase activity | ||
| metallopeptidase activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- endothelin-converting enzyme
- Functional Category
-
- K: Transcription
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| hydrolase activity |
| metal ion binding |
| metalloendopeptidase activity |
| metallopeptidase activity |
| proteolysis |
| InterPro |
|---|
| Metallopeptidase, catalytic domain superfamily |
| Peptidase M13, C-terminal domain |
| Peptidase M13, N-terminal domain |
| Peptidase M13, domain 2 |
| Peptidase M13 |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050855 | renal fibrosis | |
| DOID:10652 | Alzheimer's disease | |
| DOID:10763 | hypertension | |
| DOID:10825 | essential hypertension | |
| DOID:1184 | nephrotic syndrome | |
| DOID:12930 | dilated cardiomyopathy | |
| DOID:3021 | acute kidney failure | |
| DOID:3393 | coronary artery disease | |
| DOID:5844 | myocardial infarction | |
| DOID:6000 | congestive heart failure |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 6097252 | 6279_0:0025da | |||
| 9947441 | 7209_0:0033a9 | |||
| 9952301 | 7209_0:0035ac | |||
| 25341168 | 51031_0:004778 | |||
| 25347053 | 51031_0:000c5a | |||
| 36374689 | 34506_0:000056 | |||
| 36384018 | 34506_0:0026c9 | |||
| 66058857 | 6279_0:000dd5 | |||
| 100488407 | Xenbase:XB-GENE-1011916 | |||
| 100496473 | Xenbase:XB-GENE-989944 |
