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NRAMP-like transporter smf-3

Summary

Gene Symbol

smf-3

Organism

Caenorhabditis elegans

External Links

NCBI Gene

177044

PubChem

177044

Alliance of Genome Resources

WB:WBGene00004878

Annotation

Keyword

Cell membrane
Cytoplasmic vesicle
Glycoprotein
Iron transport
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q95XG8	DMT-1 Divalent metal transporter smf-3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
iron ion transport	IEA
intracellular iron ion homeostasis	IMP	19924247
manganese ion transport	IBA
iron ion transmembrane transport	IBA
metal ion transport	IEA

GO Hierarchy

biological process

cellular process [inference]

maintenance of location in cell [inference]

sequestering of iron ion

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

manganese ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

inorganic ion homeostasis [inference]

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

response to oxidative stress

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

response to chemical [inference]

response to inorganic substance [inference]

response to metal ion

response to manganese ion

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport

transition metal ion transport

iron ion transport

iron ion transmembrane transport

manganese ion transport

manganese ion transmembrane transport

cadmium ion transport [inference]

cadmium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

maintenance of location [inference]

sequestering of metal ion [inference]

sequestering of iron ion

maintenance of location in cell [inference]

sequestering of iron ion

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
cytoplasmic vesicle	IEA
membrane	IEA
cytoplasmic vesicle membrane	IEA
apical plasma membrane	IDA IEA	19924247
plasma membrane	IBA IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

plasma membrane

organelle membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane

endosome membrane

bounding membrane of organelle [inference]

endosome membrane

plasma membrane region [inference]

apical plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cadmium ion transmembrane transporter activity	IBA
transition metal ion transmembrane transporter activity	ISS	19924247
manganese ion transmembrane transporter activity	IBA
metal ion transmembrane transporter activity	IEA
iron ion transmembrane transporter activity	IBA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity

transition metal ion transmembrane transporter activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity

transition metal ion transmembrane transporter activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

transporter

Functional Category

K: Transcription
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
cadmium ion transmembrane transporter activity
manganese ion transmembrane transporter activity
metal ion transmembrane transporter activity

Displaying 1 entry
InterPro
NRAMP family

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
apical plasma membrane	PMID:19924247

Disease

Disease Ontology

Displaying entries **1 - 10** of 29 in total

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DO ID	Disease Name	Source
DOID:0050425	restless legs syndrome	Alliance of Genome Resources
DOID:0050456	Buruli ulcer disease	Alliance of Genome Resources
DOID:0050589	inflammatory bowel disease	Alliance of Genome Resources
DOID:0060704	lymphoproliferative syndrome	Alliance of Genome Resources
DOID:0080855	Parkinsonism	Alliance of Genome Resources
DOID:1024	leprosy	Alliance of Genome Resources
DOID:11054	urinary bladder cancer	Alliance of Genome Resources
DOID:11335	sarcoidosis	Alliance of Genome Resources
DOID:11758	iron deficiency anemia	Alliance of Genome Resources
DOID:11759	hypochromic anemia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 17 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	4891		HGNC:10908
Homo sapiens	6556		HGNC:10907
Mus musculus	18173		MGI:1345275
Mus musculus	18174		MGI:1345279
Rattus norvegicus	25715		RGD:3684
Drosophila melanogaster	42490		FB:FBgn0011672
Danio rerio	678623		ZFIN:ZDB-GENE-021115-1
Saccharomyces cerevisiae S288C	850721		SGD:S000004024
Saccharomyces cerevisiae S288C	854027		SGD:S000005482
Saccharomyces cerevisiae S288C	856447		SGD:S000001092

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Last updated: December 9, 2024