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A disintegrin and metalloproteinase with thrombospondin motifs gon-1;Peptidase M12B domain-containing protein

Summary

Gene Symbol

gon-1

Organism

Caenorhabditis elegans

External Links

NCBI Gene

177850

PubChem

177850

Alliance of Genome Resources

WB:WBGene00001650

Annotation

Keyword

Calcium
Disulfide bond
Glycoprotein
Metal-binding
Metalloprotease
Proteomics identification
Reference proteome
Secreted
Signal
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
H2L2A7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 9** of 9 in total

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GO Term	Evidence Code	PMID
gonad development	IMP	10376599 22419820
endoplasmic reticulum to Golgi vesicle-mediated transport	IMP	22419820
negative regulation of presynapse assembly	IMP	25232106
cell migration	IMP	10376599

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

cellular process [inference]

vesicle-mediated transport

Golgi vesicle transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

cell motility [inference]

cell migration

cellular localization [inference]

intracellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization

external encapsulating structure organization [inference]

extracellular matrix organization

reproductive process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development

developmental process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

muscle organ morphogenesis

anatomical structure development [inference]

animal organ development [inference]

gonad development

reproductive structure development [inference]

gonad development

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

establishment of localization [inference]

transport [inference]

vesicle-mediated transport

Golgi vesicle transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

intracellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

organic substance transport [inference]

protein transport

nitrogen compound transport [inference]

protein transport

establishment of protein localization [inference]

protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

cellular localization [inference]

intracellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of cell junction assembly [inference]

negative regulation of synapse assembly [inference]

negative regulation of presynapse assembly

negative regulation of synapse organization [inference]

negative regulation of synapse assembly [inference]

negative regulation of presynapse assembly

negative regulation of developmental process [inference]

negative regulation of nervous system development [inference]

negative regulation of synapse assembly [inference]

negative regulation of presynapse assembly

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system development [inference]

negative regulation of synapse assembly [inference]

negative regulation of presynapse assembly

regulation of developmental process [inference]

negative regulation of developmental process [inference]

negative regulation of nervous system development [inference]

negative regulation of synapse assembly [inference]

negative regulation of presynapse assembly

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

negative regulation of nervous system development [inference]

negative regulation of synapse assembly [inference]

negative regulation of presynapse assembly

regulation of cellular process [inference]

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

negative regulation of synapse assembly [inference]

negative regulation of presynapse assembly

regulation of presynapse assembly [inference]

negative regulation of presynapse assembly

negative regulation of cell junction assembly [inference]

negative regulation of synapse assembly [inference]

negative regulation of presynapse assembly

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of cell junction assembly [inference]

negative regulation of synapse assembly [inference]

negative regulation of presynapse assembly

negative regulation of synapse organization [inference]

negative regulation of synapse assembly [inference]

negative regulation of presynapse assembly

regulation of cellular component organization [inference]

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

negative regulation of synapse assembly [inference]

negative regulation of presynapse assembly

regulation of presynapse assembly [inference]

negative regulation of presynapse assembly

regulation of presynapse organization [inference]

regulation of presynapse assembly [inference]

negative regulation of presynapse assembly

negative regulation of synapse organization [inference]

negative regulation of synapse assembly [inference]

negative regulation of presynapse assembly

negative regulation of cellular component organization [inference]

negative regulation of cell junction assembly [inference]

negative regulation of synapse assembly [inference]

negative regulation of presynapse assembly

negative regulation of synapse organization [inference]

negative regulation of synapse assembly [inference]

negative regulation of presynapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

negative regulation of synapse assembly [inference]

negative regulation of presynapse assembly

regulation of presynapse assembly [inference]

negative regulation of presynapse assembly

negative regulation of cell junction assembly [inference]

negative regulation of synapse assembly [inference]

negative regulation of presynapse assembly

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system development [inference]

negative regulation of synapse assembly [inference]

negative regulation of presynapse assembly

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

negative regulation of nervous system development [inference]

negative regulation of synapse assembly [inference]

negative regulation of presynapse assembly

Displaying entry **6 - 6** of 6 in total

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GO Term	Evidence Code	PMID
Golgi apparatus	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix

collagen-containing extracellular matrix [inference]

basement membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
metal ion binding	IEA
zinc ion binding	IEA
metallopeptidase activity	IEA IMP	10376599
metalloendopeptidase activity	IBA IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:0060249	scoliosis	Alliance of Genome Resources
DOID:224	transient cerebral ischemia	Alliance of Genome Resources
DOID:7148	rheumatoid arthritis	Alliance of Genome Resources
DOID:90	degenerative disc disease	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources