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ALK tyrosine kinase receptor homolog scd-2

Summary

Gene Symbol

scd-2

Organism

Caenorhabditis elegans

External Links

NCBI Gene

179054

PubChem

179054

Alliance of Genome Resources

WB:WBGene00004740

Annotation

Keyword

3D-structure
ATP-binding
Cell membrane
Chemotaxis
Disulfide bond
Glycoprotein
Receptor
Reference proteome
Signal
Transmembrane helix
Tyrosine-protein kinase

Proteins

Displaying 1 entry
UniProt	Protein Name
O76411	Suppressor of constitutive dauer formation protein 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

1

2

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GO Term	Evidence Code	PMID
chemotaxis	IEA
regulation of neuron differentiation	IBA
protein phosphorylation	IEA
sensory perception of chemical stimulus	IGI IMP	21414922
dauer larval development	IGI	18674914

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of chemical stimulus

cognition [inference]

sensory processing

multicellular organism development [inference]

larval development [inference]

nematode larval development [inference]

dauer larval development

post-embryonic development [inference]

larval development [inference]

nematode larval development [inference]

dauer larval development

developmental process [inference]

anatomical structure development [inference]

multicellular organism development [inference]

larval development [inference]

nematode larval development [inference]

dauer larval development

locomotion [inference]

taxis [inference]

chemotaxis

biological regulation [inference]

regulation of biological process [inference]

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of neuron differentiation

regulation of cellular process [inference]

regulation of cell differentiation [inference]

regulation of neuron differentiation

Displaying 1 entry
GO Term	Evidence Code	PMID
plasma membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
transmembrane receptor protein tyrosine kinase activity	IEA
protein tyrosine kinase activity	IEA
ATP binding	IEA
protein kinase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

kinase

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
ATP binding
nucleotide binding
regulation of cell population proliferation
regulation of neuron differentiation
transmembrane receptor protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase signaling pathway

Displaying **all 6** entries
InterPro
Protein kinase domain
Protein kinase, ATP binding site
Protein kinase-like domain superfamily
Serine-threonine/tyrosine-protein kinase, catalytic domain
Tyrosine-protein kinase, active site
Tyrosine-protein kinase, catalytic domain

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:162	cancer	Alliance of Genome Resources
DOID:769	neuroblastoma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 15 in total

1

2

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Homo sapiens	238		HGNC:427
Homo sapiens	4058		HGNC:6721
Mus musculus	11682		MGI:103305
Mus musculus	17005		MGI:96840
Drosophila melanogaster	53425		FB:FBgn0040505
Rattus norvegicus	266802		RGD:628622
Rattus norvegicus	311337		RGD:1309323
Danio rerio	563509		ZFIN:ZDB-GENE-031027-1
Danio rerio	564470		ZFIN:ZDB-GENE-030616-115
Brugia malayi	6105291	6279_0:001e22

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Annotation

OrthoDB (Group)

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Acknowledgements