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Putative metalloproteinase inhibitor tag-225

Summary

Gene Symbol

cri-2

Organism

Caenorhabditis elegans

External Links

NCBI Gene

179197

PubChem

179197

Alliance of Genome Resources

WB:WBGene00019478

Annotation

Keyword

Disulfide bond
Glycoprotein
Metal-binding
Metalloprotease inhibitor
Reference proteome
Secreted
Signal
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
Q21265	TIMP-like protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
negative regulation of membrane protein ectodomain proteolysis	IBA

GO Hierarchy

biological process

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of proteolysis [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of proteolysis [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of cellular catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of membrane protein ectodomain proteolysis [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of membrane protein ectodomain proteolysis [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of cellular catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of membrane protein ectodomain proteolysis [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of proteolysis [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of membrane protein ectodomain proteolysis [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of membrane protein ectodomain proteolysis [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of proteolysis [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of proteolysis [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of membrane protein ectodomain proteolysis [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of membrane protein ectodomain proteolysis [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of proteolysis [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of membrane protein ectodomain proteolysis [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of membrane protein ectodomain proteolysis [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of proteolysis [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of proteolysis [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of proteolysis [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of cellular catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of membrane protein ectodomain proteolysis [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular matrix	IBA
extracellular region	IEA
extracellular space	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix

Displaying **all 4** entries
GO Term	Evidence Code	PMID
metalloendopeptidase inhibitor activity	IBA IEA
metal ion binding	IEA
protease binding
peptidase inhibitor activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

enzyme binding [inference]

protease binding

ion binding [inference]

cation binding [inference]

metal ion binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity

endopeptidase inhibitor activity [inference]

metalloendopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity

endopeptidase inhibitor activity [inference]

metalloendopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity [inference]

metalloendopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity

endopeptidase inhibitor activity [inference]

metalloendopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level: Eukaryota
Group Name: tissue inhibitor of metalloproteinase

Displaying **all 4** entries
Gene Ontology
metal ion binding
metalloendopeptidase inhibitor activity
negative regulation of membrane protein ectodomain proteolysis
protease binding

Displaying **all 3** entries
InterPro
Netrin domain
Protease inhibitor I35 (TIMP)
Tissue inhibitor of metalloproteinases-like, OB-fold

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
basement membrane	PMID:30992386
plasma membrane	PMID:30992386

Disease

Disease Ontology

Displaying entries **41 - 50** of 55 in total

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DO ID	Disease Name	Source
DOID:3744	cervical squamous cell carcinoma	Alliance of Genome Resources
DOID:3770	pulmonary fibrosis	Alliance of Genome Resources
DOID:3908	lung non-small cell carcinoma	Alliance of Genome Resources
DOID:3910	lung adenocarcinoma	Alliance of Genome Resources
DOID:4001	ovarian carcinoma	Alliance of Genome Resources
DOID:4362	cervical cancer	Alliance of Genome Resources
DOID:4450	renal cell carcinoma	Alliance of Genome Resources
DOID:6000	congestive heart failure	Alliance of Genome Resources
DOID:7693	abdominal aortic aneurysm	Alliance of Genome Resources
DOID:8634	prostate carcinoma in situ	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 26 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	7076		HGNC:11820
Homo sapiens	7077		HGNC:11821
Homo sapiens	7078		HGNC:11822
Homo sapiens	7079		HGNC:11823
Mus musculus	21857		MGI:98752
Mus musculus	21858		MGI:98753
Mus musculus	21859		MGI:98754
Rattus norvegicus	25358		RGD:3865
Rattus norvegicus	29543		RGD:61312
Drosophila melanogaster	41248		FB:FBgn0025879

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024