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EGF domain-specific O-linked N-acetylglucosamine transferase;Heparan N-sulfatase

Summary

Gene Symbol

H12D21.10

Organism

Caenorhabditis elegans

External Links

NCBI Gene

179990

KEGG Gene ID

cel:CELE_H12D21.10

PubChem

179990

Alliance of Genome Resources

WB:WBGene00010386

Annotation

Keyword

Glycoprotein
Glycosyltransferase
Reference proteome
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9XTX0	Extracellular O-linked N-acetylglucosamine transferase
B5BM48

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
protein O-GlcNAcylation via threonine	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via threonine [inference]

protein O-GlcNAcylation via threonine

peptidyl-amino acid modification [inference]

peptidyl-threonine modification [inference]

protein O-linked glycosylation via threonine [inference]

protein O-GlcNAcylation via threonine

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via threonine [inference]

protein O-GlcNAcylation via threonine

peptidyl-amino acid modification [inference]

peptidyl-threonine modification [inference]

protein O-linked glycosylation via threonine [inference]

protein O-GlcNAcylation via threonine

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via threonine [inference]

protein O-GlcNAcylation via threonine

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via threonine [inference]

protein O-GlcNAcylation via threonine

peptidyl-amino acid modification [inference]

peptidyl-threonine modification [inference]

protein O-linked glycosylation via threonine [inference]

protein O-GlcNAcylation via threonine

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via threonine [inference]

protein O-GlcNAcylation via threonine

peptidyl-amino acid modification [inference]

peptidyl-threonine modification [inference]

protein O-linked glycosylation via threonine [inference]

protein O-GlcNAcylation via threonine

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via threonine [inference]

protein O-GlcNAcylation via threonine

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via threonine [inference]

protein O-GlcNAcylation via threonine

peptidyl-amino acid modification [inference]

peptidyl-threonine modification [inference]

protein O-linked glycosylation via threonine [inference]

protein O-GlcNAcylation via threonine

Displaying 1 entry
GO Term	Evidence Code	PMID
endoplasmic reticulum lumen	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

Displaying **all 3** entries
GO Term	Evidence Code	PMID
glycosyltransferase activity	IEA
transferase activity	IEA
protein O-acetylglucosaminyltransferase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity

glycosyltransferase activity

UDP-glycosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

protein O-acetylglucosaminyltransferase activity

hexosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

protein O-acetylglucosaminyltransferase activity

catalytic activity, acting on a protein [inference]

protein O-acetylglucosaminyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K18134

Name

EGF domain-specific O-GlcNAc transferase [EC:2.4.1.255]

References

22158438

Rhea

UDP-N-acetyl-α-D-glucosamine

H⁺ + UDP

Enzyme

2.4.1.255

PMID

UDP-N-acetyl-α-D-glucosamine

H⁺ + UDP

Enzyme

2.4.1.255

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060227	Adams-Oliver syndrome	Alliance of Genome Resources

Ortholog

Displaying **all 6** entries
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	33424	FB:FBgn0264672
Danio rerio	798087	ZFIN:ZDB-GENE-120813-8
Xenopus tropicalis	780148	Xenbase:XB-GENE-994619
Homo sapiens	285203	HGNC:28526
Mus musculus	101351	MGI:2141669
Rattus norvegicus	494219	RGD:1359357

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 19, 2024