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Guidelines

MIRAGE

EGF domain-specific O-linked N-acetylglucosamine transferase;Heparan N-sulfatase

Summary

Gene Symbol

H12D21.10

Organism

Caenorhabditis elegans

External Links

NCBI Gene

179990

KEGG Gene ID

cel:CELE_H12D21.10

PubChem

179990

Alliance of Genome Resources

WB:WBGene00010386

Annotation

Keyword

Glycoprotein
Glycosyltransferase
Reference proteome
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9XTX0	Extracellular O-linked N-acetylglucosamine transferase
B5BM48

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
protein O-GlcNAcylation via threonine	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via threonine [inference]

protein O-GlcNAcylation via threonine

peptidyl-amino acid modification [inference]

peptidyl-threonine modification [inference]

protein O-linked glycosylation via threonine [inference]

protein O-GlcNAcylation via threonine

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via threonine [inference]

protein O-GlcNAcylation via threonine

peptidyl-amino acid modification [inference]

peptidyl-threonine modification [inference]

protein O-linked glycosylation via threonine [inference]

protein O-GlcNAcylation via threonine

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via threonine [inference]

protein O-GlcNAcylation via threonine

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via threonine [inference]

protein O-GlcNAcylation via threonine

peptidyl-amino acid modification [inference]

peptidyl-threonine modification [inference]

protein O-linked glycosylation via threonine [inference]

protein O-GlcNAcylation via threonine

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via threonine [inference]

protein O-GlcNAcylation via threonine

peptidyl-amino acid modification [inference]

peptidyl-threonine modification [inference]

protein O-linked glycosylation via threonine [inference]

protein O-GlcNAcylation via threonine

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via threonine [inference]

protein O-GlcNAcylation via threonine

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via threonine [inference]

protein O-GlcNAcylation via threonine

peptidyl-amino acid modification [inference]

peptidyl-threonine modification [inference]

protein O-linked glycosylation via threonine [inference]

protein O-GlcNAcylation via threonine

Displaying 1 entry
GO Term	Evidence Code	PMID
endoplasmic reticulum lumen	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

Displaying **all 2** entries
GO Term	Evidence Code	PMID
glycosyltransferase activity	IEA
protein O-acetylglucosaminyltransferase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity

UDP-glycosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

protein O-acetylglucosaminyltransferase activity

hexosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

protein O-acetylglucosaminyltransferase activity

catalytic activity, acting on a protein [inference]

protein O-acetylglucosaminyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

EGF domain-specific O-linked N-acetylglucosamine transferase

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
protein O-GlcNAcylation via threonine
protein O-acetylglucosaminyltransferase activity
transferase activity

Displaying **all 2** entries
InterPro
Glycosyltransferase 61, catalytic domain
Glycosyltransferase 61

KEGG BRITE Database

Orthology

K18134

Name

EGF domain-specific O-GlcNAc transferase [EC:2.4.1.255]

References

22158438

Rhea

UDP-N-acetyl-α-D-glucosamine

H⁺ + UDP

Enzyme

2.4.1.255

PMID

UDP-N-acetyl-α-D-glucosamine

H⁺ + UDP

Enzyme

2.4.1.255

PMID

Ortholog

Displaying **all 8** entries
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	33424	Xenbase:XB-GENE-994619
Xenopus tropicalis	101351	Xenbase:XB-GENE-994619
Xenopus tropicalis	179990	Xenbase:XB-GENE-994619
Xenopus tropicalis	285203	Xenbase:XB-GENE-994619
Xenopus tropicalis	443983	Xenbase:XB-GENE-994619
Xenopus tropicalis	494219	Xenbase:XB-GENE-994619
Xenopus tropicalis	780148	Xenbase:XB-GENE-994619
Xenopus tropicalis	798087	Xenbase:XB-GENE-994619

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025