GlyCosmos Portal

Annotation

Keyword

Alternative splicing
Cytoplasmic vesicle
Disulfide bond
Endosome
Glycoprotein
Lysosome
Reference proteome
Secreted
Signal
Thiol protease
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
O45734

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
regulation of apoptosis involved in tissue homeostasis	IMP	24829385
proteolysis	IEA
apoptotic cell clearance	IMP	24829385
apoptotic process	IEA
positive regulation of vitellogenesis	IMP	15456850 24829385

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process

cellular process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis [inference]

apoptotic cell clearance

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

lipid droplet organization [inference]

lipid droplet disassembly

organelle disassembly [inference]

lipid droplet disassembly

cellular component disassembly [inference]

organelle disassembly [inference]

lipid droplet disassembly

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis [inference]

apoptotic cell clearance

import into cell [inference]

endocytosis [inference]

phagocytosis [inference]

apoptotic cell clearance

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of protein maturation [inference]

regulation of protein processing

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of protein maturation [inference]

regulation of protein processing

regulation of nitrogen compound metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

regulation of protein processing

regulation of protein maturation [inference]

regulation of protein processing

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of protein maturation [inference]

regulation of protein processing

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

regulation of protein processing

regulation of protein maturation [inference]

regulation of protein processing

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

regulation of protein processing

regulation of protein maturation [inference]

regulation of protein processing

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of vitellogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of vitellogenesis

positive regulation of reproductive process [inference]

positive regulation of vitellogenesis

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of protein maturation [inference]

regulation of protein processing

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of apoptosis involved in tissue homeostasis

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of vitellogenesis

regulation of cellular component organization [inference]

positive regulation of cellular component organization [inference]

positive regulation of vitellogenesis

regulation of vitellogenesis [inference]

positive regulation of vitellogenesis

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of vitellogenesis

regulation of vitellogenesis [inference]

positive regulation of vitellogenesis

regulation of reproductive process [inference]

regulation of vitellogenesis [inference]

positive regulation of vitellogenesis

positive regulation of reproductive process [inference]

positive regulation of vitellogenesis

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GO Term	Evidence Code	PMID
yolk granule	IDA	15456850 16857685
vesicle lumen	IDA	15456850
endosome	IEA
endolysosome	IDA	22768338
extracellular region	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen

yolk granule

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

endolysosome

endocytic vesicle [inference]

phagocytic vesicle

phagolysosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

secondary lysosome [inference]

phagolysosome

endolysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

endolysosome

endocytic vesicle [inference]

phagocytic vesicle

phagolysosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

secondary lysosome [inference]

phagolysosome

endolysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

endolysosome

endocytic vesicle [inference]

phagocytic vesicle

phagolysosome

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	26780296
cysteine-type endopeptidase activity	IBA IEA
cysteine-type peptidase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

cysteine-type endopeptidase activity

cysteine-type peptidase activity

cysteine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

cysteine-type endopeptidase activity

cysteine-type peptidase activity

cysteine-type endopeptidase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cathepsin

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 4** entries
Gene Ontology
cysteine-type endopeptidase activity
hydrolase activity
proteolysis involved in protein catabolic process
proteolysis

Displaying **all 8** entries
InterPro
Cathepsin propeptide inhibitor domain (I29)
Cysteine peptidase, asparagine active site
Cysteine peptidase, cysteine active site
Cysteine peptidase, histidine active site
Papain-like cysteine endopeptidase
Papain-like cysteine peptidase superfamily
Peptidase C1A, papain C-terminal
Peptidase C1A

Alliance of Genome Resources

Expression

Displaying **all 5** entries
Location	References
annuli extracellular matrix	PMID:11707440
endolysosome	PMID:22768338
phagolysosome	PMID:24829385
collagen and cuticulin-based cuticle extracellular matrix	PMID:11707440
lysosome	PMID:24829385

Disease

Disease Ontology

Displaying entries **1 - 10** of 11 in total

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DO ID	Disease Name	Source
DOID:10754	otitis media	Alliance of Genome Resources
DOID:1184	nephrotic syndrome	Alliance of Genome Resources
DOID:11984	hypertrophic cardiomyopathy	Alliance of Genome Resources
DOID:12930	dilated cardiomyopathy	Alliance of Genome Resources
DOID:1574	alcohol use disorder	Alliance of Genome Resources
DOID:2316	brain ischemia	Alliance of Genome Resources
DOID:4989	pancreatitis	Alliance of Genome Resources
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources
DOID:767	muscular atrophy	Alliance of Genome Resources
DOID:7998	hyperthyroidism	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 50 in total

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Species	Gene ID	Alliance of Genome Resources
Homo sapiens	1514	HGNC:2537
Homo sapiens	1515	HGNC:2538
Mus musculus	13039	MGI:88564
Rattus norvegicus	25697	RGD:2448
Mus musculus	26898	MGI:1349426
Rattus norvegicus	29174	RGD:69241
Drosophila melanogaster	36546	FB:FBgn0013770
Mus musculus	56092	MGI:1860262
Mus musculus	56094	MGI:1860275
Mus musculus	56835	MGI:1861723

GlyTouCan

GlyComb

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LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements