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cathepsin 7

Summary

Gene Symbol

Cts7

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

290970

PubChem

290970

Alliance of Genome Resources

RGD:1309226

Annotation

Keyword

Cytoplasm
Disulfide bond
Endosome
Glycoprotein
Golgi apparatus
Lysosome
Mitosis
Nucleus
Reference proteome
Secreted
Signal
Thiol protease
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
D3ZZ07

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
trophoblast giant cell differentiation	ISO
mitotic cell cycle	ISO
apoptotic process	IEA
cell division	IEA
positive regulation of apoptotic signaling pathway	IBA

GO Hierarchy

biological process

immune system process [inference]

immune response

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process

cellular process [inference]

cell cycle [inference]

mitotic cell cycle

cell death [inference]

programmed cell death [inference]

apoptotic process

cellular developmental process [inference]

cell differentiation [inference]

cell differentiation involved in embryonic placenta development [inference]

trophoblast giant cell differentiation

cell division

reproductive process [inference]

developmental process involved in reproduction [inference]

cell differentiation involved in embryonic placenta development [inference]

trophoblast giant cell differentiation

developmental process [inference]

developmental process involved in reproduction [inference]

cell differentiation involved in embryonic placenta development [inference]

trophoblast giant cell differentiation

cellular developmental process [inference]

cell differentiation [inference]

cell differentiation involved in embryonic placenta development [inference]

trophoblast giant cell differentiation

response to stimulus [inference]

immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell cycle [inference]

negative regulation of mitotic cell cycle

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell cycle [inference]

negative regulation of mitotic cell cycle

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle

negative regulation of cell cycle [inference]

negative regulation of mitotic cell cycle

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
Golgi apparatus	ISO
endosome	ISO
extracellular region	ISO
lysosome	IBA ISO
extracellular space	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle [inference]

nucleus

vacuole [inference]

lytic vacuole [inference]

lysosome

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

vacuole [inference]

lytic vacuole [inference]

lysosome

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

perinuclear region of cytoplasm

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cysteine-type endopeptidase activity	IBA
cysteine-type endopeptidase activator activity involved in apoptotic process	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

cysteine-type endopeptidase activity

cysteine-type peptidase activity [inference]

cysteine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

cysteine-type endopeptidase activity

cysteine-type peptidase activity [inference]

cysteine-type endopeptidase activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

peptidase activator activity [inference]

peptidase activator activity involved in apoptotic process [inference]

cysteine-type endopeptidase activator activity involved in apoptotic process

cysteine-type endopeptidase regulator activity involved in apoptotic process [inference]

cysteine-type endopeptidase activator activity involved in apoptotic process

peptidase regulator activity [inference]

peptidase activator activity [inference]

peptidase activator activity involved in apoptotic process [inference]

cysteine-type endopeptidase activator activity involved in apoptotic process

molecular function activator activity [inference]

enzyme activator activity [inference]

peptidase activator activity [inference]

peptidase activator activity involved in apoptotic process [inference]

cysteine-type endopeptidase activator activity involved in apoptotic process

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Cathepsin S

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 3** entries
Gene Ontology
cysteine-type endopeptidase activity
proteolysis involved in protein catabolic process
proteolysis

Displaying **all 3** entries
InterPro
Papain-like cysteine peptidase superfamily
Peptidase C1A, papain C-terminal
Peptidase C1A

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:1574	alcohol use disorder	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 62 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	36546		FB:FBgn0013770
Mus musculus	56092	10090_1:00415d	MGI:1860262	MOUSE12170
Caenorhabditis elegans	180111		WB:WBGene00000776
Danio rerio	321453		ZFIN:ZDB-GENE-030131-106
Danio rerio	321853		ZFIN:ZDB-GENE-121214-52
Danio rerio	449826		ZFIN:ZDB-GENE-041010-76
Danio rerio	564835		ZFIN:ZDB-GENE-121214-37
Danio rerio	567623		ZFIN:ZDB-GENE-080215-7
Danio rerio	100001785		ZFIN:ZDB-GENE-121214-39
Danio rerio	100537591		ZFIN:ZDB-GENE-071004-116