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dihydropyrimidinase like 2

Summary

Gene Symbol

DPYSL2

Organism

Homo sapiens (human)

External Links

NCBI Gene

1808

PubChem

1808

Alliance of Genome Resources

HGNC:3014

Annotation

Keyword

3D-structure
Alternative splicing
Cytoskeleton
Developmental protein
Differentiation
Direct protein sequencing
Membrane
Methylation
Neurogenesis
Phosphoprotein
Proteomics identification
Reference proteome
S-nitrosylation

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A1C7CYX9
Q16555	Collapsin response mediator protein 2 N2A3 Unc-33-like phosphoprotein 2
Q59GB4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
nucleobase-containing compound metabolic process	TAS	8973361
pyrimidine nucleobase catabolic process	IBA
endocytosis	IMP	20801876
cytoskeleton organization	ISS
signal transduction	TAS	8973361

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

cellular nitrogen compound catabolic process [inference]

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

organonitrogen compound metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

organonitrogen compound catabolic process [inference]

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

catabolic process [inference]

cellular catabolic process [inference]

cellular nitrogen compound catabolic process [inference]

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

heterocycle catabolic process [inference]

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

organic substance catabolic process [inference]

organic cyclic compound catabolic process [inference]

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

organonitrogen compound catabolic process [inference]

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

cellular nitrogen compound catabolic process [inference]

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

cellular catabolic process [inference]

cellular nitrogen compound catabolic process [inference]

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

heterocycle catabolic process [inference]

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

heterocycle catabolic process [inference]

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

organic substance metabolic process [inference]

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

organic cyclic compound catabolic process [inference]

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

organonitrogen compound metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

organonitrogen compound catabolic process [inference]

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

organic substance catabolic process [inference]

organic cyclic compound catabolic process [inference]

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

organonitrogen compound catabolic process [inference]

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

cellular process [inference]

signal transduction

vesicle-mediated transport [inference]

endocytosis

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

cellular nitrogen compound catabolic process [inference]

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

cellular catabolic process [inference]

cellular nitrogen compound catabolic process [inference]

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

heterocycle catabolic process [inference]

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

heterocycle catabolic process [inference]

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process

cellular developmental process [inference]

cell differentiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization

developmental process [inference]

anatomical structure development [inference]

system development [inference]

nervous system development

cellular developmental process [inference]

cell differentiation

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis

import into cell [inference]

endocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
cytosol	TAS
cytosol	IDA	20801876
cytosol	IBA
cytoskeleton
microtubule	IDA	20801876

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane

plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

spindle [inference]

mitotic spindle

cytoskeleton

microtubule cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

spindle [inference]

mitotic spindle

cytoskeleton

microtubule cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

Displaying **all 4** entries
GO Term	Evidence Code	PMID
dihydropyrimidinase activity	IBA
protein binding	IPI	16260607 19235893 21900206 24722188 25416956 28514442 29892012 31515488 32296183 32814053 33961781 36950384
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	IBA
identical protein binding	IPI	21516116 25416956 29892012 31515488 32296183

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

dihydropyrimidinase activity

binding [inference]

protein binding

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

dihydropyrimidinase

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
hydrolase activity

Displaying **all 3** entries
InterPro
Amidohydrolase-related
Metal-dependent hydrolase, composite domain superfamily
Metal-dependent hydrolase

Ortholog

Displaying entries **31 - 40** of 96 in total

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Species	Gene ID	Orthologous MAtrix
Oreochromis niloticus	100705567	ORENI66781
Cavia porcellus	100734407	CAVPO00711
Cricetulus griseus	100759148	CRIGR13775
Sarcophilus harrisii	100931719	SARHA17637
Otolemur garnettii	100961333	OTOGA08535
Pan paniscus	100987385	PANPA37904
Papio anubis	101019659	PAPAN38584
Saimiri boliviensis boliviensis	101028756	SAIBB28070
Takifugu rubripes	101079435	TAKRU44676
Ovis aries	101108984	SHEEP08896

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OrthoDB (Group)

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Acknowledgements