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G-protein coupled receptors family 1 profile domain-containing protein

Summary

Gene Symbol

ser-5

Organism

Caenorhabditis elegans

External Links

NCBI Gene

184572

PubChem

184572

Alliance of Genome Resources

WB:WBGene00008890

Annotation

Keyword

Cell membrane
G-protein coupled receptor
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
G5EBX8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 11 in total

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GO Term	Evidence Code	PMID
cell-cell signaling	IBA
phospholipase C-activating G protein-coupled receptor signaling pathway	IBA
positive regulation of cytosolic calcium ion concentration	IBA
G protein-coupled receptor signaling pathway	IEA
serotonin receptor signaling pathway	IMP	19193891 22768843

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling

signal transduction [inference]

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

adrenergic receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

serotonin receptor signaling pathway

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of chemical stimulus

behavior [inference]

feeding behavior [inference]

eating behavior [inference]

nematode pharyngeal pumping

response to stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

signaling [inference]

cell-cell signaling

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of multicellular organismal process [inference]

positive regulation of behavior [inference]

positive regulation of egg-laying behavior

positive regulation of reproductive process [inference]

positive regulation of egg-laying behavior

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

adrenergic receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

serotonin receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of multicellular organismal process [inference]

regulation of behavior [inference]

regulation of egg-laying behavior [inference]

positive regulation of egg-laying behavior

positive regulation of behavior [inference]

positive regulation of egg-laying behavior

positive regulation of multicellular organismal process [inference]

positive regulation of behavior [inference]

positive regulation of egg-laying behavior

regulation of reproductive process [inference]

regulation of egg-laying behavior [inference]

positive regulation of egg-laying behavior

positive regulation of reproductive process [inference]

positive regulation of egg-laying behavior

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration

Displaying **all 2** entries
GO Term	Evidence Code	PMID
membrane	IEA
plasma membrane	IBA IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
signaling receptor activity	IEA
alpha1-adrenergic receptor activity	IBA
G protein-coupled receptor activity	IEA

GO Hierarchy

molecular function

molecular transducer activity [inference]

signaling receptor activity

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

G protein-coupled amine receptor activity [inference]

adrenergic receptor activity [inference]

alpha-adrenergic receptor activity [inference]

alpha1-adrenergic receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

5-hydroxytryptamine receptor

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
adenylate cyclase-activating adrenergic receptor signaling pathway
adrenergic receptor activity
alpha1-adrenergic receptor activity
cell-cell signaling
phospholipase C-activating G protein-coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration

Displaying **all 2** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:11612	polycystic ovary syndrome	Alliance of Genome Resources
DOID:13948	bladder neck obstruction	Alliance of Genome Resources
DOID:9976	heroin dependence	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 14 in total

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Species	Gene ID	Alliance of Genome Resources
Homo sapiens	147	HGNC:278
Homo sapiens	148	HGNC:277
Mus musculus	11548	MGI:104774
Mus musculus	11549	MGI:104773
Rattus norvegicus	24173	RGD:2054
Rattus norvegicus	29412	RGD:2055
Danio rerio	492486	ZFIN:ZDB-GENE-041114-51
Danio rerio	557259	ZFIN:ZDB-GENE-060503-384
Danio rerio	568614	ZFIN:ZDB-GENE-090312-203
Danio rerio	798498	ZFIN:ZDB-GENE-030131-2831