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peptidylglycine alpha-amidating monooxygenase

Summary

Gene Symbol

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

18484

PubChem

18484

Alliance of Genome Resources

MGI:97475

Annotation

Keyword

Calcium
Cleavage on pair of basic residues
Copper
Cytoplasmic vesicle
Disulfide bond
Glycoprotein
Lipid metabolism
Lyase
Metal-binding
Monooxygenase
Multifunctional enzyme
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Signal
Transmembrane helix
Vitamin C
Zinc

Proteins

Displaying **all 4** entries
UniProt	Protein Name
E9Q704
A1L331
F8VQA4
P97467

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
peptide amidation	ISS
peptide amidation	ISO
long-chain fatty acid metabolic process	ISO
regulation of transcription by RNA polymerase II	ISO
peptide metabolic process	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

fatty acid primary amide biosynthetic process

amide metabolic process [inference]

peptide metabolic process

peptide modification [inference]

peptide amidation

amide biosynthetic process [inference]

fatty acid primary amide biosynthetic process

fatty acid primary amide metabolic process [inference]

fatty acid primary amide biosynthetic process

organonitrogen compound metabolic process [inference]

peptide metabolic process

peptide modification [inference]

peptide amidation

fatty acid primary amide metabolic process [inference]

fatty acid primary amide biosynthetic process

organonitrogen compound biosynthetic process [inference]

fatty acid primary amide biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

fatty acid primary amide biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

fatty acid primary amide biosynthetic process

organonitrogen compound biosynthetic process [inference]

fatty acid primary amide biosynthetic process

secondary metabolic process [inference]

toxin metabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process

toxin metabolic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

fatty acid primary amide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

fatty acid primary amide biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

fatty acid primary amide biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process

fatty acid derivative metabolic process [inference]

fatty acid primary amide metabolic process [inference]

fatty acid primary amide biosynthetic process

fatty acid derivative biosynthetic process [inference]

fatty acid primary amide biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

fatty acid primary amide biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process

fatty acid derivative metabolic process [inference]

fatty acid primary amide metabolic process [inference]

fatty acid primary amide biosynthetic process

fatty acid derivative biosynthetic process [inference]

fatty acid primary amide biosynthetic process

organonitrogen compound metabolic process [inference]

peptide metabolic process

peptide modification [inference]

peptide amidation

fatty acid primary amide metabolic process [inference]

fatty acid primary amide biosynthetic process

organonitrogen compound biosynthetic process [inference]

fatty acid primary amide biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

fatty acid primary amide biosynthetic process

organonitrogen compound biosynthetic process [inference]

fatty acid primary amide biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process

toxin metabolic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

fatty acid primary amide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

fatty acid primary amide biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process

response to stimulus [inference]

response to abiotic stimulus [inference]

response to pH

response to chemical [inference]

response to xenobiotic stimulus

response to inorganic substance [inference]

response to metal ion [inference]

response to zinc ion

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
extracellular region	IBA
extracellular space	ISO
trans-Golgi network	ISO
cytosol	TAS	10219055
plasma membrane	TAS	10219055

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

bounding membrane of organelle [inference]

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

perikaryon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

cell body [inference]

neuronal cell body

perinuclear region of cytoplasm

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
peptidylglycine monooxygenase activity	ISS
peptidylglycine monooxygenase activity	ISO
peptidylglycine monooxygenase activity	TAS	10219055
peptidylglycine monooxygenase activity	IBA
peptidylamidoglycolate lyase activity	ISS

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen [inference]

peptidylglycine monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen [inference]

peptidylglycine monooxygenase activity

lyase activity [inference]

carbon-nitrogen lyase activity [inference]

amidine-lyase activity [inference]

peptidylamidoglycolate lyase activity

catalytic activity, acting on a protein [inference]

peptidylamidoglycolate lyase activity

binding [inference]

protein binding [inference]

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

identical protein binding

carbohydrate binding [inference]

monosaccharide binding [inference]

L-ascorbic acid binding

small molecule binding [inference]

vitamin binding [inference]

L-ascorbic acid binding

organic acid binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

monosaccharide binding [inference]

L-ascorbic acid binding

heterocyclic compound binding [inference]

L-ascorbic acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

cation binding [inference]

metal ion binding [inference]

calcium ion binding

transition metal ion binding [inference]

organic cyclic compound binding [inference]

L-ascorbic acid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Peptidyl-glycine alpha-amidating monooxygenase

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 7** entries
Gene Ontology
catalytic activity
copper ion binding
metal ion binding
monooxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
peptide metabolic process
peptidylglycine monooxygenase activity

Displaying **all 8** entries
InterPro
Copper type II ascorbate-dependent monooxygenase, C-terminal
Copper type II, ascorbate-dependent monooxygenase, N-terminal domain superfamily
Copper type II, ascorbate-dependent monooxygenase, N-terminal
Copper type II, ascorbate-dependent monooxygenase-like, C-terminal
NHL repeat
PHM/PNGase F domain superfamily
Peptidylglycine alpha-hydroxylating monooxygenase/peptidyl-hydroxyglycine alpha-amidating lyase
Six-bladed beta-propeller, TolB-like

Ortholog

Displaying entries **11 - 20** of 87 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Macaca mulatta	707733		MACMU39189
Monodelphis domestica	100030601		MONDO16536
Ornithorhynchus anatinus	100073355		ORNAN01447
Xenopus tropicalis	100170159	Xenbase:XB-GENE-950935
Oryctolagus cuniculus	100352005		RABIT01820
Callithrix jacchus	100396001		CALJA25194
Pongo abelii	100449730		PONAB30185
Ailuropoda melanoleuca	100484534		AILME08869
Sus scrofa	100526040		PIGXX19481
Anolis carolinensis	100562563		ANOCA17964

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OrthoDB (Group)

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Acknowledgements