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proprotein convertase subtilisin/kexin type 4

Summary

Gene Symbol

Pcsk4

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

18551

PubChem

18551

Alliance of Genome Resources

MGI:97514

Annotation

Keyword

Alternative splicing
Cleavage on pair of basic residues
Cytoplasmic vesicle
Glycoprotein
Membrane
Reference proteome
Serine protease
Signal
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
P29121	KEX2-like endoprotease 3 Neuroendocrine convertase 3 Prohormone convertase 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
reproductive process	IMP	9192653
binding of sperm to zona pellucida	IMP	16371590
sperm capacitation	IDA IMP	16371590 19342015 21302280
acrosome reaction	IMP	16371590
peptide hormone processing	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

hormone metabolic process [inference]

peptide hormone processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

cellular process [inference]

cell recognition [inference]

cell-cell recognition [inference]

sperm-egg recognition [inference]

binding of sperm to zona pellucida

cellular process involved in reproduction in multicellular organism [inference]

sperm capacitation

cellular developmental process [inference]

cell maturation [inference]

sperm capacitation

reproductive process

developmental process involved in reproduction [inference]

sperm capacitation

cellular process involved in reproduction in multicellular organism [inference]

sperm capacitation

sperm-egg recognition [inference]

binding of sperm to zona pellucida

developmental process [inference]

developmental process involved in reproduction [inference]

sperm capacitation

developmental maturation [inference]

anatomical structure maturation [inference]

cell maturation [inference]

sperm capacitation

cellular developmental process [inference]

cell maturation [inference]

sperm capacitation

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing

Displaying **all 5** entries
GO Term	Evidence Code	PMID
acrosomal membrane	IDA	16371590
endoplasmic reticulum lumen	TAS
trans-Golgi network	IBA
Golgi membrane	IBA
acrosomal vesicle	IDA	21302280

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane [inference]

acrosomal membrane

bounding membrane of organelle [inference]

Golgi membrane

secretory granule membrane [inference]

acrosomal membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

Displaying 1 entry
GO Term	Evidence Code	PMID
serine-type endopeptidase activity	IBA IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

proprotein convertase subtilisin/kexin type 4

Functional Category

L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
hydrolase activity
peptide hormone processing
proteolysis
serine-type endopeptidase activity
serine-type peptidase activity

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0050861	colorectal adenocarcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **41 - 50** of 69 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Vulpes vulpes	112935597		VULVU31841
Urocitellus parryii	113200473	9999_0:004045
Bos indicus x Bos taurus	113895404		BOBOX25447
Vombatus ursinus	114036636		VOMUR25143
Marmota flaviventris	114105997	93162_0:0038f2
Podarcis muralis	114588417		PODMU21760
Grammomys surdaster	114624639	491861_0:0019b6
Peromyscus leucopus	114684129	10041_0:00413b
Mastomys coucha	116076091	35658_0:003d43
Corvus moneduloides	116436137		CORMO13552

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements