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Tyrosine-protein kinase receptor ver-4

Summary

Gene Symbol

ver-4

Organism

Caenorhabditis elegans

External Links

NCBI Gene

186632

PubChem

186632

Alliance of Genome Resources

WB:WBGene00006897

Annotation

Keyword

ATP-binding
Cell membrane
Disulfide bond
Glycoprotein
Immunoglobulin domain
Receptor
Reference proteome
Repeat
Transmembrane helix
Tyrosine-protein kinase

Proteins

Displaying 1 entry
UniProt	Protein Name
Q21041	Vascular endothelial growth factor receptor related 4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
anatomical structure morphogenesis	IEA
protein phosphorylation	IEA
nematode male tail tip morphogenesis	IGI	24004945
multicellular organism development	IBA
transmembrane receptor protein tyrosine kinase signaling pathway	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

reproductive process [inference]

developmental process involved in reproduction [inference]

male anatomical structure morphogenesis [inference]

nematode male tail tip morphogenesis

multicellular organismal process [inference]

multicellular organism development

developmental process [inference]

developmental process involved in reproduction [inference]

male anatomical structure morphogenesis [inference]

nematode male tail tip morphogenesis

anatomical structure morphogenesis

male anatomical structure morphogenesis [inference]

nematode male tail tip morphogenesis

anatomical structure development [inference]

multicellular organism development

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

Displaying **all 2** entries
GO Term	Evidence Code	PMID
receptor complex	IBA
plasma membrane	IBA IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
transmembrane receptor protein tyrosine kinase activity	IBA IEA
protein tyrosine kinase activity	IEA
ATP binding	IEA
protein kinase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Protein kinase domain-containing protein

Functional Category

K: Transcription
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
ATP binding
anatomical structure morphogenesis
metal ion binding
nucleotide binding
transmembrane receptor protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase signaling pathway

Displaying entries **1 - 10** of 11 in total

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InterPro
Immunoglobulin subtype 2
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold
Protein kinase domain
Protein kinase, ATP binding site
Protein kinase-like domain superfamily
Serine-threonine/tyrosine-protein kinase, catalytic domain
Tyrosine-protein kinase, active site

Disease

Disease Ontology

Displaying entries **1 - 10** of **109** in total

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DO ID	Disease Name	Source
DOID:0002116	pterygium	Alliance of Genome Resources
DOID:0050580	hereditary lymphedema	Alliance of Genome Resources
DOID:0050861	colorectal adenocarcinoma	Alliance of Genome Resources
DOID:0050866	oral squamous cell carcinoma	Alliance of Genome Resources
DOID:0050904	salivary gland carcinoma	Alliance of Genome Resources
DOID:0060074	ductal carcinoma in situ	Alliance of Genome Resources
DOID:0060108	brain glioma	Alliance of Genome Resources
DOID:0060180	colitis	Alliance of Genome Resources
DOID:0060224	atrial fibrillation	Alliance of Genome Resources
DOID:0060669	cerebral cavernous malformation	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 22 in total

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Species	Gene ID	Alliance of Genome Resources
Homo sapiens	1436	HGNC:2433
Homo sapiens	2321	HGNC:3763
Homo sapiens	2322	HGNC:3765
Homo sapiens	2324	HGNC:3767
Homo sapiens	3791	HGNC:6307
Homo sapiens	3815	HGNC:6342
Mus musculus	12978	MGI:1339758
Mus musculus	14254	MGI:95558
Mus musculus	14257	MGI:95561
Mus musculus	16542	MGI:96683

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Annotation

OrthoDB (Group)

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Acknowledgements