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mixed lineage kinase domain like pseudokinase

Summary

Gene Symbol

MLKL

Organism

Homo sapiens (human)

External Links

NCBI Gene

197259

PubChem

197259

Alliance of Genome Resources

HGNC:26617

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Cell membrane
Coiled coil
Cytoplasm
Necrosis
Nucleus
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8NB16

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
protein phosphorylation
cell surface receptor signaling pathway	IEA
defense response to virus	ISS
protein homotrimerization	IDA	24316671
necroptotic process	IMP	22265414 24316671 29883610

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular process [inference]

signal transduction [inference]

cell death [inference]

programmed cell death [inference]

programmed necrotic cell death [inference]

necroptotic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotrimerization

protein trimerization [inference]

protein homotrimerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotrimerization

protein trimerization [inference]

protein homotrimerization

execution phase of necroptosis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
nucleus	ISS
cytoplasm	IDA	24316671
cytoplasm	IBA
cytosol	TAS
cytosol	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell junction

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

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GO Term	Evidence Code	PMID
protein kinase activity	ISS
protein serine/threonine kinase activity	IBA
protein binding	IPI	22265413 22265414 29883609 32296183
ATP binding	IDA	24219132
protein kinase binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity

protein serine/threonine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

protein serine/threonine kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity

protein serine/threonine kinase activity

binding [inference]

protein binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

identical protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein-containing complex binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Mixed lineage kinase domain-like

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ATP binding
cell surface receptor signaling pathway
nucleotide binding

Displaying **all 4** entries
InterPro
Adaptor protein Cbl, N-terminal domain superfamily
Protein kinase domain
Protein kinase-like domain superfamily
Serine-threonine/tyrosine-protein kinase, catalytic domain

Ortholog

Displaying entries **1 - 10** of 60 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	74568	Xenbase:XB-GENE-948713	MOUSE58382
Xenopus tropicalis	197259	Xenbase:XB-GENE-948713
Rattus norvegicus	690743		RATNO15165
Macaca mulatta	710316		MACMU27585
Pan troglodytes	736069		PANTR12843
Bos taurus	790225		BOVIN10133
Equus caballus	100068748		HORSE31487
Ciona intestinalis	100185956		CIOIN06858
Salmo salar	100195264		SALSA09224
Taeniopygia guttata	100223797		TAEGU03116