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erythrocyte membrane protein band 4.1 like 2

Summary

Gene Symbol

EPB41L2

Organism

Homo sapiens (human)

External Links

NCBI Gene

2037

PubChem

2037

Alliance of Genome Resources

HGNC:3379

Annotation

Keyword

Acetylation
Actin-binding
Alternative splicing
Cell membrane
Cytoskeleton
Direct protein sequencing
Isopeptide bond
Mitosis
Phosphoprotein
Reference proteome
Transport
Ubl conjugation

Proteins

Displaying **all 4** entries
UniProt	Protein Name
I6L9B1
B4DJ76
Q59FD8
O43491	Erythrocyte membrane protein band 4.1-like 2 Generally expressed protein 4.1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
cortical actin cytoskeleton organization	IEA
actomyosin structure organization	IBA
cell division	IEA
positive regulation of protein localization to cell cortex	IMP	23870127

GO Hierarchy

biological process

cellular process [inference]

actin filament-based process [inference]

actin cytoskeleton organization [inference]

cell division

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization [inference]

cortical cytoskeleton organization [inference]

cortical actin cytoskeleton organization

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to cell cortex

regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to cell cortex

regulation of protein localization to cell cortex [inference]

positive regulation of protein localization to cell cortex

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to cell cortex

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to cell cortex

regulation of cellular localization [inference]

regulation of protein localization [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to cell cortex

regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to cell cortex

regulation of protein localization to cell cortex [inference]

positive regulation of protein localization to cell cortex

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
nucleoplasm	IDA
cytosol	TAS
cytoskeleton	IBA
plasma membrane	IDA
plasma membrane	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

spectrin

nuclear protein-containing complex [inference]

COP9 signalosome

cellular anatomical entity [inference]

nucleoplasm

cytoplasm [inference]

cell cortex

cytosol

membrane [inference]

plasma membrane

cell junction

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
actin binding	IEA
structural molecule activity	IEA
protein binding	IPI	20936779 22003208 23870127 24996901 28514442 33961781 36931259 39251607
spectrin binding	IEA
PH domain binding	IEA

GO Hierarchy

molecular function

structural molecule activity

binding [inference]

protein binding

cytoskeletal protein binding [inference]

protein domain specific binding [inference]

PH domain binding

protein-containing complex binding [inference]

spectrin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

band 4.1-like protein

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
actin binding
cytoskeletal protein binding
structural molecule activity

Displaying entries **11 - 12** of 12 in total

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InterPro
PH-like domain superfamily
Ubiquitin-like domain superfamily

Ortholog

Displaying entries **1 - 10** of 64 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	2035	FB:FBgn0010434
Drosophila melanogaster	2036	FB:FBgn0010434
Xenopus tropicalis	2037	Xenbase:XB-GENE-988171
Drosophila melanogaster	13821	FB:FBgn0010434
Mus musculus	13822	Xenbase:XB-GENE-988171	MOUSE02190
Drosophila melanogaster	13823	FB:FBgn0010434
Drosophila melanogaster	23136	FB:FBgn0010434
Drosophila melanogaster	37205	FB:FBgn0010434
Drosophila melanogaster	59317	FB:FBgn0010434
Rattus norvegicus	309557		RATNO19488