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MIRAGE

SUMO specific peptidase 5

Summary

Gene Symbol

SENP5

Organism

Homo sapiens (human)

External Links

NCBI Gene

205564

PubChem

205564

Alliance of Genome Resources

HGNC:28407

Annotation

Keyword

Alternative splicing
Cell division
Nucleus
Reference proteome
Thiol protease
Ubl conjugation pathway

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B2R9F5
Q96HI0	Sentrin/SUMO-specific protease SENP5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
proteolysis	IEA
protein sumoylation	TAS
protein desumoylation	IBA
cell division	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

protein modification by small protein removal [inference]

protein desumoylation

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

protein modification by small protein removal [inference]

protein desumoylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

protein modification by small protein removal [inference]

protein desumoylation

macromolecule modification [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

protein modification by small protein removal [inference]

protein desumoylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

protein modification by small protein removal [inference]

protein desumoylation

cellular process [inference]

cell division

Displaying **all 5** entries
GO Term	Evidence Code	PMID
nucleus	IBA
nucleoplasm	TAS
nucleolus	IEA
presynaptic cytosol	IEA
postsynaptic cytosol	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

cytosol [inference]

cytosolic region [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

nucleolus

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	21217774
deSUMOylase activity	IBA
SUMO-specific endopeptidase activity	EXP	16608850 17591783

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

cysteine-type endopeptidase activity [inference]

ubiquitin-like protein-specific endopeptidase activity [inference]

SUMO-specific endopeptidase activity

cysteine-type peptidase activity [inference]

cysteine-type endopeptidase activity [inference]

ubiquitin-like protein-specific endopeptidase activity [inference]

SUMO-specific endopeptidase activity

deSUMOylase activity

ubiquitin-like protein peptidase activity [inference]

deSUMOylase activity

ubiquitin-like protein-specific endopeptidase activity [inference]

SUMO-specific endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

cysteine-type endopeptidase activity [inference]

ubiquitin-like protein-specific endopeptidase activity [inference]

SUMO-specific endopeptidase activity

cysteine-type peptidase activity [inference]

cysteine-type endopeptidase activity [inference]

ubiquitin-like protein-specific endopeptidase activity [inference]

SUMO-specific endopeptidase activity

deSUMOylase activity

ubiquitin-like protein peptidase activity [inference]

deSUMOylase activity

ubiquitin-like protein-specific endopeptidase activity [inference]

SUMO-specific endopeptidase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Sentrin-specific protease

Functional Category

L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
proteolysis

Displaying **all 2** entries
InterPro
Papain-like cysteine peptidase superfamily
Ulp1 protease family, C-terminal catalytic domain

Ortholog

Displaying entries **1 - 10** of 55 in total

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Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	29843	SGD:S000005941
Xenopus tropicalis	205564	Xenbase:XB-GENE-486043
Saccharomyces cerevisiae S288C	223870	SGD:S000005941
Mus musculus	320213		MOUSE19339
Pan troglodytes	471052		PANTR33034
Canis lupus familiaris	488033		CANLF13409
Rattus norvegicus	690251		RATNO15405
Macaca mulatta	710223		MACMU30119
Equus caballus	100069684		HORSE14217
Oryctolagus cuniculus	100340254		RABIT04715

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025