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erythropoietin receptor

Summary

Gene Symbol

EPOR

Organism

Homo sapiens (human)

External Links

NCBI Gene

2057

PubChem

2057

Alliance of Genome Resources

HGNC:3416

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Congenital erythrocytosis
Disease variant
Disulfide bond
Glycoprotein
Isopeptide bond
Phosphoprotein
Proteomics identification
Receptor
Reference proteome
Secreted
Signal
Transmembrane helix
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P19235

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

1

2

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GO Term	Evidence Code	PMID
signal transduction	NAS	1668606
brain development	IEA
heart development	IEA
positive regulation of cell population proliferation	IBA
cytokine-mediated signaling pathway	IBA

GO Hierarchy

biological process

cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

erythropoietin-mediated signaling pathway

cellular developmental process [inference]

cell development [inference]

hemopoiesis

reproductive process [inference]

developmental process involved in reproduction [inference]

decidualization

developmental process [inference]

developmental process involved in reproduction [inference]

decidualization

anatomical structure development [inference]

tissue development [inference]

decidualization

cell development [inference]

hemopoiesis

animal organ development [inference]

cellular developmental process [inference]

cell development [inference]

hemopoiesis

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

erythropoietin-mediated signaling pathway

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

Displaying **all 5** entries
GO Term	Evidence Code	PMID
extracellular region	IEA
plasma membrane	TAS
plasma membrane	IDA
external side of plasma membrane	IBA
nuclear speck	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

membrane [inference]

plasma membrane

nuclear body [inference]

nuclear speck

side of membrane [inference]

external side of plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
erythropoietin receptor activity	IDA	2163696 9774108
erythropoietin receptor activity	IBA
protein binding	IPI	11781573 11784712 14527337 15644415 25092874 26481148 29997244 7228577 7528537 7528577 9774108
identical protein binding	IPI	16116438 21058338

GO Hierarchy

molecular function

binding [inference]

protein binding

identical protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity [inference]

erythropoietin receptor activity

immune receptor activity [inference]

cytokine receptor activity [inference]

erythropoietin receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Erythropoietin receptor

Functional Category

I: Lipid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
cytokine-mediated signaling pathway
erythropoietin receptor activity

Displaying **all 5** entries
InterPro
Erythropoietin receptor
Fibronectin type III superfamily
Fibronectin type III
Growth hormone/erythropoietin receptor, ligand binding
Immunoglobulin-like fold

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0060652	familial erythrocytosis 1	Alliance of Genome Resources
DOID:2355	anemia	Alliance of Genome Resources
DOID:3070	high grade glioma	Alliance of Genome Resources
DOID:8432	polycythemia	Alliance of Genome Resources
DOID:9074	systemic lupus erythematosus	Alliance of Genome Resources