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MIRAGE
Erythropoietin receptor
Summary
- UniProt ID
- P19235
- Gene Symbol
-
- EPOR
- Gene ID
- 2057
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Cell membrane
- Congenital erythrocytosis
- Disease variant
- Disulfide bond
- Glycoprotein
- Isopeptide bond
- Phosphoprotein
- Receptor
- Reference proteome
- Secreted
- Signal
- Transmembrane helix
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular region |
| plasma membrane |
| external side of plasma membrane |
| nuclear speck |
| GO Term |
|---|
| erythropoietin receptor activity |
| identical protein binding |
Sequence
MDHLGASLWPQVGSLCLLLAGAAWAPPPNLPDPKFESKAALLAARGPEELLCFTERLEDLVCFWEEAASAGVGPGNYSFSYQLEDEPWKLCRLHQAPTARGAVRFWCSLPTADTSSFVPLELRVTAASGAPRYHRVIHINEVVLLDAPVGLVARLADESGHVVLRWLPPPETPMTSHIRYEVDVSAGNGAGSVQRVEILEGRTECVLSNLRGRTRYTFAVRARMAEPSFGGFWSAWSEPVSLLTPSDLDPLILTLSLILVVILVLLTVLALLSHRRALKQKIWPGIPSPESEFEGLFTTHKGNFQLWLYQNDGCLWWSPCTPFTEDPPASLEVLSERCWGTMQAVEPGTDDEGPLLEPVGSEHAQDTYLVLDKWLLPRNPPSEDLPGPGGSVDIVAMDEGSEASSCSSALASKPSPEGASAASFEYTILDPSSQLLRPWTLCPELPPTPPHLKYLYLVVSDSGISTDYSSGDSQGAQGGLSDGPYSNPYENSLIPAAEPLPPSYVACS
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 76 | N-linked (GlcNAc...) asparagine |
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | Homo sapiens |
| Erythropoietin activates Phospholipase C gamma (PLCG) | Homo sapiens |
| Erythropoietin activates RAS | Homo sapiens |
| Erythropoietin activates STAT5 | Homo sapiens |
| Signaling by Erythropoietin | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060652 | familial erythrocytosis 1 | |
| DOID:2355 | anemia | |
| DOID:3070 | high grade glioma | |
| DOID:8432 | polycythemia | |
| DOID:9074 | systemic lupus erythematosus |
