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syntaxin 1A (brain)

Summary

Gene Symbol

Stx1a

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

20907

PubChem

20907

Alliance of Genome Resources

MGI:109355

Annotation

Keyword

Cell membrane
Coiled coil
Cytoplasmic vesicle
Direct protein sequencing
Exocytosis
Isopeptide bond
Neurotransmitter transport
Phosphoprotein
Reference proteome
Synaptosome
Transmembrane helix
Ubl conjugation

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q497P1
O35526	Neuron-specific antigen HPC-1
Q5D0A4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 36 in total

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GO Term	Evidence Code	PMID
positive regulation of neurotransmitter secretion	ISO
positive regulation of neurotransmitter secretion	IGI	24133272
intracellular protein transport	IBA
intracellular protein transport	IEA
exocytosis	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein sumoylation

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein sumoylation

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein sumoylation

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

macromolecule modification [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein sumoylation

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein sumoylation

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

cellular process [inference]

vesicle-mediated transport [inference]

exocytosis

regulated exocytosis

endocytosis [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

synaptic vesicle exocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

membrane docking [inference]

organelle localization by membrane tethering [inference]

vesicle docking

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

localization within membrane [inference]

protein localization to membrane

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vesicle organization [inference]

vesicle fusion

vesicle fusion to plasma membrane [inference]

synaptic vesicle fusion to presynaptic active zone membrane

organelle fusion [inference]

organelle membrane fusion [inference]

vesicle fusion

vesicle fusion to plasma membrane [inference]

synaptic vesicle fusion to presynaptic active zone membrane

cellular component assembly [inference]

protein-containing complex assembly [inference]

SNARE complex assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

SNARE complex assembly

membrane organization [inference]

synaptic vesicle membrane organization [inference]

synaptic vesicle fusion to presynaptic active zone membrane

membrane fusion

organelle membrane fusion [inference]

vesicle fusion

vesicle fusion to plasma membrane [inference]

synaptic vesicle fusion to presynaptic active zone membrane

exocytic process [inference]

vesicle fusion to plasma membrane [inference]

synaptic vesicle fusion to presynaptic active zone membrane

export from cell [inference]

secretion by cell

exocytosis

regulated exocytosis

protein secretion [inference]

insulin secretion

signal release [inference]

hormone secretion

peptide hormone secretion [inference]

insulin secretion

signal release from synapse [inference]

synaptic vesicle exocytosis

response to stimulus [inference]

response to abiotic stimulus [inference]

response to gravity

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to membrane

establishment of localization [inference]

transport [inference]

hormone transport [inference]

hormone secretion

peptide hormone secretion [inference]

insulin secretion

vesicle-mediated transport [inference]

exocytosis

regulated exocytosis

endocytosis [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

synaptic vesicle exocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

secretion [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion

secretion by cell

exocytosis

regulated exocytosis

protein secretion [inference]

insulin secretion

signal release [inference]

hormone secretion

peptide hormone secretion [inference]

insulin secretion

signal release from synapse [inference]

synaptic vesicle exocytosis

intracellular transport [inference]

intracellular protein transport

organic substance transport [inference]

protein transport [inference]

intracellular protein transport

protein secretion [inference]

insulin secretion

peptide transport [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport

protein secretion [inference]

insulin secretion

amide transport [inference]

peptide transport [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion

import into cell [inference]

endocytosis [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

export from cell [inference]

secretion by cell

exocytosis

regulated exocytosis

protein secretion [inference]

insulin secretion

signal release [inference]

hormone secretion

peptide hormone secretion [inference]

insulin secretion

signal release from synapse [inference]

synaptic vesicle exocytosis

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

establishment of localization in cell [inference]

synaptic vesicle exocytosis

intracellular transport [inference]

intracellular protein transport

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

organelle localization [inference]

organelle localization by membrane tethering [inference]

vesicle docking

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

localization within membrane [inference]

protein localization to membrane

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

modulation of excitatory postsynaptic potential

positive regulation of excitatory postsynaptic potential

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of neurotransmitter secretion [inference]

positive regulation of neurotransmitter secretion

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion

modulation of excitatory postsynaptic potential

positive regulation of excitatory postsynaptic potential

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion

positive regulation of catecholamine secretion

positive regulation of norepinephrine secretion

positive regulation of exocytosis

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

regulation of secretion by cell [inference]

regulation of exocytosis

positive regulation of exocytosis

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

regulation of regulated secretory pathway [inference]

regulation of calcium ion-dependent exocytosis [inference]

positive regulation of calcium ion-dependent exocytosis

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

regulation of neurotransmitter secretion [inference]

positive regulation of neurotransmitter secretion

regulation of catecholamine secretion [inference]

regulation of norepinephrine secretion [inference]

positive regulation of norepinephrine secretion

positive regulation of catecholamine secretion

positive regulation of norepinephrine secretion

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion

positive regulation of catecholamine secretion

positive regulation of norepinephrine secretion

positive regulation of exocytosis

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion

positive regulation of catecholamine secretion

positive regulation of norepinephrine secretion

positive regulation of exocytosis

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

positive regulation of neurotransmitter transport [inference]

positive regulation of neurotransmitter secretion

positive regulation of amine transport [inference]

positive regulation of catecholamine secretion

positive regulation of norepinephrine secretion

regulation of neurotransmitter transport [inference]

regulation of neurotransmitter secretion [inference]

positive regulation of neurotransmitter secretion

positive regulation of neurotransmitter transport [inference]

positive regulation of neurotransmitter secretion

regulation of amine transport [inference]

regulation of catecholamine secretion [inference]

regulation of norepinephrine secretion [inference]

positive regulation of norepinephrine secretion

positive regulation of catecholamine secretion

positive regulation of norepinephrine secretion

positive regulation of amine transport [inference]

positive regulation of catecholamine secretion

positive regulation of norepinephrine secretion

regulation of vesicle-mediated transport [inference]

regulation of exocytosis

positive regulation of exocytosis

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

regulation of regulated secretory pathway [inference]

regulation of calcium ion-dependent exocytosis [inference]

positive regulation of calcium ion-dependent exocytosis

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion

positive regulation of catecholamine secretion

positive regulation of norepinephrine secretion

positive regulation of exocytosis

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion

positive regulation of catecholamine secretion

positive regulation of norepinephrine secretion

positive regulation of exocytosis

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

positive regulation of neurotransmitter transport [inference]

positive regulation of neurotransmitter secretion

positive regulation of amine transport [inference]

positive regulation of catecholamine secretion

positive regulation of norepinephrine secretion

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

modulation of excitatory postsynaptic potential

positive regulation of excitatory postsynaptic potential

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

modulation of excitatory postsynaptic potential

positive regulation of excitatory postsynaptic potential

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of neurotransmitter secretion [inference]

positive regulation of neurotransmitter secretion

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion

modulation of excitatory postsynaptic potential

positive regulation of excitatory postsynaptic potential

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

regulation of synaptic vesicle priming

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion

positive regulation of catecholamine secretion

positive regulation of norepinephrine secretion

positive regulation of exocytosis

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

regulation of cellular component organization [inference]

regulation of protein-containing complex assembly [inference]

regulation of synaptic vesicle priming

regulation of vesicle-mediated transport [inference]

regulation of exocytosis

positive regulation of exocytosis

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

regulation of regulated secretory pathway [inference]

regulation of calcium ion-dependent exocytosis [inference]

positive regulation of calcium ion-dependent exocytosis

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

regulation of secretion by cell [inference]

regulation of exocytosis

positive regulation of exocytosis

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

regulation of regulated secretory pathway [inference]

regulation of calcium ion-dependent exocytosis [inference]

positive regulation of calcium ion-dependent exocytosis

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

regulation of neurotransmitter secretion [inference]

positive regulation of neurotransmitter secretion

regulation of catecholamine secretion [inference]

regulation of norepinephrine secretion [inference]

positive regulation of norepinephrine secretion

positive regulation of catecholamine secretion

positive regulation of norepinephrine secretion

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion

positive regulation of catecholamine secretion

positive regulation of norepinephrine secretion

positive regulation of exocytosis

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of nervous system process [inference]

modulation of excitatory postsynaptic potential

positive regulation of excitatory postsynaptic potential

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone transport [inference]

hormone secretion

peptide hormone secretion [inference]

insulin secretion

regulation of membrane potential [inference]

modulation of excitatory postsynaptic potential

positive regulation of excitatory postsynaptic potential

Displaying entries **1 - 5** of 32 in total

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GO Term	Evidence Code	PMID
acrosomal vesicle	EXP	16540102
plasma membrane	ISO
plasma membrane	TAS	12145198
plasma membrane	IDA	10468580 23821748
plasma membrane	IBA

GO Hierarchy

cellular component

protein-containing complex

membrane protein complex [inference]

SNARE complex

plasma membrane protein complex [inference]

voltage-gated potassium channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex [inference]

voltage-gated potassium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex [inference]

voltage-gated potassium channel complex

cellular anatomical entity [inference]

endomembrane system

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

nuclear membrane

bounding membrane of organelle [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic specialization membrane [inference]

postsynaptic density membrane

cell junction [inference]

synapse [inference]

actomyosin

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

axon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

secretory granule

acrosomal vesicle

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

secretory granule

acrosomal vesicle

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

secretory granule

acrosomal vesicle

exocytic vesicle [inference]

synaptic vesicle

postsynaptic specialization [inference]

postsynaptic density

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GO Term	Evidence Code	PMID
SNARE binding	ISO	7553862
SNARE binding	IDA	12145198
SNARE binding	IBA
SNAP receptor activity	IBA
SNAP receptor activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

SNARE binding

cytoskeletal protein binding [inference]

myosin binding

myosin heavy chain binding [inference]

myosin head/neck binding

enzyme binding [inference]

kinase binding

protein-containing complex binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity

SNAP receptor activity

molecular function regulator activity [inference]

molecular function inhibitor activity [inference]

transporter inhibitor activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity [inference]

transporter regulator activity [inference]

channel regulator activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity [inference]

ion channel regulator activity [inference]

calcium channel regulator activity [inference]

calcium channel inhibitor activity

ion channel inhibitor activity [inference]

chloride channel regulator activity [inference]

chloride channel inhibitor activity

transporter inhibitor activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

SYNTAXIN

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:150	disease of mental health	Alliance of Genome Resources

Ortholog

Displaying entries **41 - 50** of 65 in total

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Species	Gene ID	Orthologous MAtrix
Aotus nancymaae	105714909	AOTNA08007
Propithecus coquereli	105807057	PROCO12699
Dipodomys ordii	105998479	DIPOR20080
Cyprinodon variegatus	107081878	CYPVA03714
Sinocyclocheilus grahami	107567686	SINGR93330
Kryptolebias marmoratus	108240947	KRYMA16429
Pygocentrus nattereri	108424058	PYGNA05000
Rhinopithecus bieti	108517367	RHIBE42194
Cyprinus carpio carpio	109061509	CYPCA114885
Crocodylus porosus	109317609	CROPO24615

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements