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synaptojanin 2

Summary

Gene Symbol

Synj2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

20975

PubChem

20975

Alliance of Genome Resources

MGI:1201671

Annotation

Keyword

Alternative splicing
Cell membrane
Cell projection
Cytoskeleton
Hydrolase
Lipid metabolism
Phosphoprotein
Proteomics identification
RNA-binding
Reference proteome
Synapse

Proteins

Displaying **all 5** entries
UniProt	Protein Name
Q9D2G5	Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2
Q3TTB3
F8WHD8
E9Q4P5
D3YZB2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
inositol phosphate catabolic process	ISO
phosphatidylinositol dephosphorylation	IEA ISO
synaptic vesicle endocytosis	IBA ISO

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

small molecule catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

inositol phosphate catabolic process

organic substance catabolic process [inference]

organophosphate catabolic process [inference]

inositol phosphate catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

inositol phosphate catabolic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

dephosphorylation [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

inositol phosphate metabolic process [inference]

inositol phosphate catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

inositol phosphate metabolic process [inference]

inositol phosphate catabolic process

organophosphate catabolic process [inference]

inositol phosphate catabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

inositol phosphate metabolic process [inference]

inositol phosphate catabolic process

polyol catabolic process [inference]

inositol phosphate catabolic process

alcohol catabolic process [inference]

polyol catabolic process [inference]

inositol phosphate catabolic process

small molecule catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

inositol phosphate catabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

inositol phosphate metabolic process [inference]

inositol phosphate catabolic process

organophosphate catabolic process [inference]

inositol phosphate catabolic process

organic substance catabolic process [inference]

organophosphate catabolic process [inference]

inositol phosphate catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

inositol phosphate catabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

inositol phosphate metabolic process [inference]

inositol phosphate catabolic process

polyol catabolic process [inference]

inositol phosphate catabolic process

alcohol catabolic process [inference]

polyol catabolic process [inference]

inositol phosphate catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

inositol phosphate catabolic process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

dephosphorylation [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

inositol phosphate metabolic process [inference]

inositol phosphate catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

inositol phosphate metabolic process [inference]

inositol phosphate catabolic process

organophosphate catabolic process [inference]

inositol phosphate catabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

import into cell [inference]

endocytosis [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

establishment of localization in cell [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
axon terminus	ISO
membrane	IBA
presynapse	IBA IEA ISO
ruffle membrane	ISO
plasma membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

ruffle membrane

membrane microdomain [inference]

membrane raft

leading edge membrane [inference]

ruffle membrane

cell projection

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

neuron projection terminus [inference]

axon terminus

perinuclear region of cytoplasm

axon terminus

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule [inference]

cytoplasmic microtubule

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
SH3 domain binding	ISO
phosphatidylinositol monophosphate phosphatase activity	ISO
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	IBA IDA	9442075
inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity	ISO
PDZ domain binding	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

inositol phosphate phosphatase activity [inference]

inositol trisphosphate phosphatase activity [inference]

inositol-1,4,5-trisphosphate 5-phosphatase activity

inositol tetrakisphosphate phosphatase activity [inference]

inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity

phosphatidylinositol phosphate phosphatase activity [inference]

phosphatidylinositol bisphosphate phosphatase activity [inference]

phosphatidylinositol-4,5-bisphosphate phosphatase activity [inference]

phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity

phosphatidylinositol phosphate 5-phosphatase activity [inference]

phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity

phosphatidylinositol monophosphate phosphatase activity

binding [inference]

protein binding [inference]

protein domain specific binding [inference]

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

synaptojanin-2 isoform a

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription

Displaying **all 3** entries
Gene Ontology
SH3 domain binding
lipid metabolic process
phosphatidylinositol phosphate phosphatase activity

Displaying **all 9** entries
InterPro
Endonuclease/exonuclease/phosphatase superfamily
Inositol 5-phosphatase
Inositol polyphosphate-related phosphatase
Nucleotide-binding alpha-beta plait domain superfamily
RNA recognition motif domain
RNA-binding domain superfamily
SAC domain
Synaptojanin-1/2, RNA recognition motif
Synaptojanin-2, RNA recognition motif

Rhea

H₂O + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)

phosphate + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)

Enzyme

3.1.3.36

PMID

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0060894	early-onset Parkinson's disease	Alliance of Genome Resources
DOID:14250	Down syndrome	Alliance of Genome Resources
DOID:14330	Parkinson's disease	Alliance of Genome Resources

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001398
Gene Name: synaptojanin 2

Ortholog

Displaying entries **21 - 30** of 97 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Loxodonta africana	100654255			LOXAF05072
Cavia porcellus	100716353	10141_0:002052		CAVPO15594
Cricetulus griseus	100774472	10029_0:0019ee		CRIGR10495
Sarcophilus harrisii	100920906			SARHA04521
Papio anubis	101024196			PAPAN34693
Saimiri boliviensis boliviensis	101047067			SAIBB22587
Felis catus	101087233			FELCA10679
Ovis aries	101109366			SHEEP18924
Gorilla gorilla gorilla	101131117			GORGO37482
Tursiops truncatus	101324840			TURTR10784

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024