exostosin like glycosyltransferase 2

Summary
Gene Symbol
  • EXTL2
Aliases
  • alpha-1,4-N-acteylhexosaminyltransferase
Organism
Homo sapiens (human)
External Links
NCBI Gene
2135
GGDB ID
HGNC
3516
mRNA
map
  • 1p21
Protein
OMIM
KEGG Gene ID
hsa:2135
PubChem
2135
Alliance of Genome Resources
Annotation
Keyword
  • Direct protein sequencing
  • Disulfide bond
  • Endoplasmic reticulum
  • Glycoprotein
  • Glycosyltransferase
  • Manganese
  • Metal-binding
  • Proteomics identification
  • Reference proteome
  • Secreted
  • Signal-anchor
  • Transmembrane helix
Proteins
Displaying all 3 entries
UniProt Protein Name
Q8N8F1
F5GZK1
Q9UBQ6
  • Alpha-1,4-N-acetylhexosaminyltransferase EXTL2
  • Alpha-GalNAcT EXTL2
  • EXT-related protein 2
  • Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
Gene Ontology (GO)
GO Hierarchy
Human Protein Atlas
ENSG00000162694

soft tissue soft tissue blood blood blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node kidney kidney adrenal gland adrenal gland breast breast duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland nasopharynx nasopharynx tongue tonsil tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder ductus deferens ductus deferens seminal vesicle seminal vesicle seminal vesicle seminal vesicle testis testis epididymis epididymis brain smooth muscle urinary bladder prostate bone marrow skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus cartilage sole of foot sole of foot soft tissue blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lactating breast lactating breast kidney kidney adrenal gland adrenal gland duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland salivary gland salivary gland salivary gland salivary gland salivary gland nasopharynx tongue tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder brain skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus smooth muscle urinary bladder vagina ovary ovary fallopian tube fallopian tube endometrium placenta cervix cervix bone marrow cartilage sole of foot sole of foot olfactory region cerebral cortex cerebellum medulla pons midbrain pituitary gland hypothalamus amygdala thalamus choroid plexus choroid plexus corpus callosum basal ganglia substantia nigra dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe caudate hippocampus retina retina

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

GlycoGene Database (GGDB)
GGDB ID
gg161
Gene Symbol
  • EXTL2
Reactions
Displaying all 4 entries
Donor Acceptor Product Reference
UDP-GlcNAc
G99041PQ
UDP-GalNAc
G12916RQ
UDP-GalNAc
G99041PQ
UDP-GlcNAc
G12916RQ
Displaying all 4 entries
Donor Acceptor Product Reference
UDP-GlcNAc
G12916RQ
UDP-GalNAc
G99041PQ
UDP-GalNAc
G12916RQ
UDP-GlcNAc
G99041PQ
Orthologous Gene
Displaying all 2 entries
Species Protein mRNA
Rattus norvegicus XP_227614 XM_227614
Mus musculus NP_067363 NM_021388
Disease
Disease Ontology
Displaying entries 1 - 10 of 14 in total
DO ID Disease Name Source
DOID:0110938 autosomal dominant osteopetrosis 2
DOID:0110946 autosomal recessive osteopetrosis 7
DOID:0111393 mucopolysaccharidosis type IIIC
DOID:0111395 mucopolysaccharidosis type IIIA
DOID:12798 mucopolysaccharidosis
DOID:12799 mucopolysaccharidosis II
DOID:12800 mucopolysaccharidosis VI
DOID:12801 mucopolysaccharidosis III
DOID:12804 mucopolysaccharidosis IV
DOID:13533 osteopetrosis

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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 19, 2024