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MIRAGE

inositol 1,3,4-triphosphate 5/6 kinase

Summary

Gene Symbol

Itpk1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

217837

PubChem

217837

Alliance of Genome Resources

MGI:2446159

Annotation

Keyword

ATP-binding
Acetylation
Hydrolase
Isomerase
Kinase
Magnesium
Metal-binding
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8BYN3	Inositol 1,3,4-trisphosphate 5/6-kinase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
phosphorylation
neural tube development	IMP	19482943
inositol trisphosphate metabolic process	IEA
necroptotic process	ISS
necroptotic process	ISO

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation

inositol phosphate metabolic process [inference]

inositol trisphosphate metabolic process

organophosphate metabolic process [inference]

inositol phosphate metabolic process [inference]

inositol trisphosphate metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

inositol phosphate metabolic process [inference]

inositol trisphosphate metabolic process

organic substance metabolic process [inference]

organophosphate metabolic process [inference]

inositol phosphate metabolic process [inference]

inositol trisphosphate metabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

inositol phosphate metabolic process [inference]

inositol trisphosphate metabolic process

cellular process [inference]

cell death [inference]

programmed cell death [inference]

programmed necrotic cell death [inference]

necroptotic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation

inositol phosphate metabolic process [inference]

inositol trisphosphate metabolic process

organophosphate metabolic process [inference]

inositol phosphate metabolic process [inference]

inositol trisphosphate metabolic process

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

epithelium development [inference]

neural tube development

tube development [inference]

neural tube development

Displaying 1 entry
GO Term	Evidence Code	PMID
apical plasma membrane	IDA	16537650

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane region [inference]

apical plasma membrane

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
magnesium ion binding	IEA
inositol tetrakisphosphate 6-kinase activity	ISS
inositol tetrakisphosphate 6-kinase activity	ISO
ATP binding	IEA
hydrolase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

inositol tetrakisphosphate kinase activity [inference]

inositol trisphosphate kinase activity [inference]

phosphotransferase activity, alcohol group as acceptor [inference]

inositol tetrakisphosphate kinase activity [inference]

inositol trisphosphate kinase activity [inference]

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Inositol-tetrakisphosphate 1-kinase

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying entries **1 - 10** of 11 in total

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Gene Ontology
ATP binding
inositol tetrakisphosphate 1-kinase activity
inositol trisphosphate metabolic process
inositol-1,3,4-trisphosphate 5-kinase activity
inositol-1,3,4-trisphosphate 6-kinase activity
kinase activity
magnesium ion binding
metal ion binding
nucleotide binding
phosphorylation

Displaying **all 3** entries
InterPro
Inositol 1,3,4-trisphosphate 5/6-kinase, ATP-grasp domain
Inositol-tetrakisphosphate 1-kinase, N-terminal
Inositol-tetrakisphosphate 1-kinase

Rhea

ATP + 1D-myo-inositol 1,3,4-trisphosphate

H⁺ + ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate

Enzyme

2.7.1.159

PMID

ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate

H⁺ + ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

Enzyme

2.7.1.134

PMID

ATP + 1D-myo-inositol 1,3,4-trisphosphate

H⁺ + ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate

Enzyme

2.7.1.159

PMID

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP005842
Gene Name: inositol 1,3,4-triphosphate 5/6 kinase

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025