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CD40 ligand

Summary

Gene Symbol

Cd40lg

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

21947

PubChem

21947

Alliance of Genome Resources

MGI:88337

Annotation

Keyword

Cell membrane
Cytokine
Disulfide bond
Glycoprotein
Reference proteome
Secreted
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q0VEI3	Tumor necrosis factor ligand superfamily member 5
P27548	T-cell antigen Gp39 TNF-related activation protein Tumor necrosis factor ligand superfamily member 5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 39 in total

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GO Term	Evidence Code	PMID
immunoglobulin production	IGI	15485634
regulation of immunoglobulin production	IDA	12958312
positive regulation of immune response to tumor cell	ISO
inflammatory response	ISS
inflammatory response	ISO

GO Hierarchy

biological process

immune system process [inference]

somatic diversification of immune receptors [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

somatic diversification of immunoglobulins [inference]

somatic diversification of immunoglobulins involved in immune response [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

immune effector process [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

production of molecular mediator of immune response [inference]

immunoglobulin production

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

lymphocyte differentiation [inference]

B cell differentiation

B cell activation [inference]

B cell activation involved in immune response [inference]

isotype switching

lymphocyte proliferation [inference]

B cell proliferation

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

production of molecular mediator of immune response [inference]

immunoglobulin production

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

production of molecular mediator of immune response [inference]

immunoglobulin production

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

production of molecular mediator of immune response [inference]

immunoglobulin production

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

production of molecular mediator of immune response [inference]

immunoglobulin production

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

production of molecular mediator of immune response [inference]

immunoglobulin production

cellular process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

platelet activation

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

lymphocyte differentiation [inference]

B cell differentiation

B cell activation [inference]

B cell activation involved in immune response [inference]

isotype switching

lymphocyte proliferation [inference]

B cell proliferation

signal transduction

cell surface receptor signaling pathway

cell population proliferation [inference]

leukocyte proliferation [inference]

mononuclear cell proliferation [inference]

lymphocyte proliferation [inference]

B cell proliferation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

production of molecular mediator of immune response [inference]

immunoglobulin production

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation

dendritic cell differentiation

multicellular organismal process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

platelet activation

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

lymphocyte differentiation [inference]

B cell differentiation

B cell activation [inference]

B cell activation involved in immune response [inference]

isotype switching

lymphocyte proliferation [inference]

B cell proliferation

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation

dendritic cell differentiation

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of B cell activation [inference]

positive regulation of B cell proliferation

positive regulation of immune response [inference]

positive regulation of immune response to tumor cell

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of dendritic cell differentiation

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of B cell activation [inference]

positive regulation of B cell proliferation

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

regulation of B cell proliferation [inference]

positive regulation of B cell proliferation

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of lymphocyte proliferation [inference]

regulation of T cell activation [inference]

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

regulation of B cell activation [inference]

regulation of B cell proliferation [inference]

positive regulation of B cell proliferation

positive regulation of B cell activation [inference]

positive regulation of B cell proliferation

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of B cell activation [inference]

positive regulation of B cell proliferation

regulation of immune effector process [inference]

regulation of production of molecular mediator of immune response [inference]

regulation of immunoglobulin production

regulation of immune response [inference]

regulation of immune response to tumor cell [inference]

positive regulation of immune response to tumor cell

positive regulation of immune response [inference]

positive regulation of immune response to tumor cell

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of dendritic cell differentiation

regulation of dendritic cell differentiation [inference]

positive regulation of dendritic cell differentiation

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of dendritic cell differentiation

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of MHC class II biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

regulation of type II interferon production [inference]

positive regulation of type II interferon production

regulation of interleukin-10 production [inference]

positive regulation of interleukin-10 production

regulation of interleukin-12 production [inference]

positive regulation of interleukin-12 production

regulation of interleukin-4 production [inference]

positive regulation of interleukin-4 production

regulation of production of molecular mediator of immune response [inference]

regulation of immunoglobulin production

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of MHC class II biosynthetic process

regulation of MHC class II biosynthetic process [inference]

positive regulation of MHC class II biosynthetic process

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of MHC class II biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of MHC class II biosynthetic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of MHC class II biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of MHC class II biosynthetic process

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of MHC class II biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

regulation of type II interferon production [inference]

positive regulation of type II interferon production

regulation of interleukin-10 production [inference]

positive regulation of interleukin-10 production

regulation of interleukin-12 production [inference]

positive regulation of interleukin-12 production

regulation of interleukin-4 production [inference]

positive regulation of interleukin-4 production

regulation of production of molecular mediator of immune response [inference]

regulation of immunoglobulin production

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of MHC class II biosynthetic process

regulation of MHC class II biosynthetic process [inference]

positive regulation of MHC class II biosynthetic process

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of MHC class II biosynthetic process

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

regulation of type II interferon production [inference]

positive regulation of type II interferon production

regulation of interleukin-10 production [inference]

positive regulation of interleukin-10 production

regulation of interleukin-12 production [inference]

positive regulation of interleukin-12 production

regulation of interleukin-4 production [inference]

positive regulation of interleukin-4 production

regulation of production of molecular mediator of immune response [inference]

regulation of immunoglobulin production

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of MHC class II biosynthetic process

regulation of MHC class II biosynthetic process [inference]

positive regulation of MHC class II biosynthetic process

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of MHC class II biosynthetic process

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of B cell activation [inference]

positive regulation of B cell proliferation

positive regulation of immune response [inference]

positive regulation of immune response to tumor cell

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of dendritic cell differentiation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of MHC class II biosynthetic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of MHC class II biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of MHC class II biosynthetic process

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of MHC class II biosynthetic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of epithelial cell apoptotic process [inference]

positive regulation of endothelial cell apoptotic process

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of dendritic cell differentiation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of B cell activation [inference]

positive regulation of B cell proliferation

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of response to tumor cell [inference]

positive regulation of immune response to tumor cell

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of immune response [inference]

positive regulation of immune response to tumor cell

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of dendritic cell differentiation

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of B cell activation [inference]

positive regulation of B cell proliferation

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of dendritic cell differentiation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of response to tumor cell [inference]

positive regulation of immune response to tumor cell

regulation of response to tumor cell [inference]

positive regulation of response to tumor cell [inference]

positive regulation of immune response to tumor cell

regulation of immune response to tumor cell [inference]

positive regulation of immune response to tumor cell

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of response to tumor cell [inference]

positive regulation of immune response to tumor cell

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of immune response [inference]

positive regulation of immune response to tumor cell

regulation of immune response [inference]

regulation of immune response to tumor cell [inference]

positive regulation of immune response to tumor cell

positive regulation of immune response [inference]

positive regulation of immune response to tumor cell

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of dendritic cell differentiation

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of dendritic cell differentiation

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of dendritic cell differentiation

regulation of dendritic cell differentiation [inference]

positive regulation of dendritic cell differentiation

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of dendritic cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of dendritic cell differentiation

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of dendritic cell differentiation

regulation of dendritic cell differentiation [inference]

positive regulation of dendritic cell differentiation

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of dendritic cell differentiation

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of MHC class II biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

regulation of type II interferon production [inference]

positive regulation of type II interferon production

regulation of interleukin-10 production [inference]

positive regulation of interleukin-10 production

regulation of interleukin-12 production [inference]

positive regulation of interleukin-12 production

regulation of interleukin-4 production [inference]

positive regulation of interleukin-4 production

regulation of production of molecular mediator of immune response [inference]

regulation of immunoglobulin production

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of MHC class II biosynthetic process

regulation of MHC class II biosynthetic process [inference]

positive regulation of MHC class II biosynthetic process

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of MHC class II biosynthetic process

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

regulation of leukocyte proliferation [inference]

regulation of mononuclear cell proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

regulation of lymphocyte proliferation [inference]

regulation of B cell proliferation [inference]

positive regulation of B cell proliferation

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of epithelial cell apoptotic process [inference]

positive regulation of endothelial cell apoptotic process

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

negative regulation of apoptotic process

regulation of epithelial cell apoptotic process [inference]

positive regulation of epithelial cell apoptotic process [inference]

positive regulation of endothelial cell apoptotic process

regulation of endothelial cell apoptotic process [inference]

positive regulation of endothelial cell apoptotic process

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of epithelial cell apoptotic process [inference]

positive regulation of endothelial cell apoptotic process

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of dendritic cell differentiation

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of dendritic cell differentiation

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of dendritic cell differentiation

regulation of dendritic cell differentiation [inference]

positive regulation of dendritic cell differentiation

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of dendritic cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of MHC class II biosynthetic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of epithelial cell apoptotic process [inference]

positive regulation of endothelial cell apoptotic process

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of dendritic cell differentiation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of B cell activation [inference]

positive regulation of B cell proliferation

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of B cell activation [inference]

positive regulation of B cell proliferation

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

regulation of B cell proliferation [inference]

positive regulation of B cell proliferation

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of lymphocyte proliferation [inference]

regulation of T cell activation [inference]

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

regulation of B cell activation [inference]

regulation of B cell proliferation [inference]

positive regulation of B cell proliferation

positive regulation of B cell activation [inference]

positive regulation of B cell proliferation

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of B cell activation [inference]

positive regulation of B cell proliferation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of B cell activation [inference]

positive regulation of B cell proliferation

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

regulation of type II interferon production [inference]

positive regulation of type II interferon production

regulation of interleukin-10 production [inference]

positive regulation of interleukin-10 production

regulation of interleukin-12 production [inference]

positive regulation of interleukin-12 production

regulation of interleukin-4 production [inference]

positive regulation of interleukin-4 production

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of B cell activation [inference]

positive regulation of B cell proliferation

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

regulation of B cell proliferation [inference]

positive regulation of B cell proliferation

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of lymphocyte proliferation [inference]

regulation of T cell activation [inference]

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

regulation of B cell activation [inference]

regulation of B cell proliferation [inference]

positive regulation of B cell proliferation

positive regulation of B cell activation [inference]

positive regulation of B cell proliferation

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of B cell activation [inference]

positive regulation of B cell proliferation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of B cell activation [inference]

positive regulation of B cell proliferation

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of B cell activation [inference]

positive regulation of B cell proliferation

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of dendritic cell differentiation

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of dendritic cell differentiation

regulation of dendritic cell differentiation [inference]

positive regulation of dendritic cell differentiation

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of dendritic cell differentiation

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
extracellular space	ISO
extracellular space	IBA
extracellular space	IEA
Golgi apparatus	ISO
Golgi apparatus	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell projection

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

cell body

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
cytokine activity	IBA
cytokine activity	IEA
tumor necrosis factor receptor binding	IEA
CD40 receptor binding	ISS
CD40 receptor binding	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

cytokine receptor binding [inference]

tumor necrosis factor receptor superfamily binding [inference]

integrin binding

receptor ligand activity [inference]

cytokine activity

cell adhesion molecule binding [inference]

integrin binding

protein-containing complex binding [inference]

integrin binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

kinase activator activity [inference]

protein kinase activator activity [inference]

protein serine/threonine kinase activator activity

kinase regulator activity [inference]

kinase activator activity [inference]

protein kinase activator activity [inference]

protein serine/threonine kinase activator activity

protein kinase regulator activity [inference]

protein kinase activator activity [inference]

protein serine/threonine kinase activator activity

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

molecular function activator activity [inference]

enzyme activator activity [inference]

kinase activator activity [inference]

protein kinase activator activity [inference]

protein serine/threonine kinase activator activity

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cd40 ligand

Functional Category

M: Cell wall/membrane/envelope biogenesis
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
CD40 receptor binding
cytokine activity
immune response
tumor necrosis factor receptor binding

Displaying **all 4** entries
InterPro
CD40 ligand
Tumour necrosis factor domain
Tumour necrosis factor, conserved site
Tumour necrosis factor-like domain superfamily

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0050589	inflammatory bowel disease	Alliance of Genome Resources
DOID:9074	systemic lupus erythematosus	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 64 in total

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Species	Gene ID	Orthologous MAtrix
Cavia porcellus	100733664	CAVPO20297
Cricetulus griseus	100763089	CRIGR06599
Sarcophilus harrisii	100918070	SARHA02012
Otolemur garnettii	100964652	OTOGA01130
Pan paniscus	100975410	PANPA42181
Papio anubis	101011100	PAPAN42204
Saimiri boliviensis boliviensis	101051030	SAIBB33786
Gorilla gorilla gorilla	101152672	GORGO43686
Tursiops truncatus	101337561	TURTR09743
Dasypus novemcinctus	101426835	DASNO12253

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements