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Fc alpha receptor

Summary

Gene Symbol

FCAR

Organism

Homo sapiens (human)

External Links

NCBI Gene

2204

PubChem

2204

Alliance of Genome Resources

HGNC:3608

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disulfide bond
Glycoprotein
IgA-binding protein
Immunoglobulin domain
Receptor
Reference proteome
Repeat
Secreted
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P24071

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
neutrophil mediated immunity	IDA	25339672
immune response-regulating signaling pathway	IBA
immune response	TAS	10835685
positive regulation of neutrophil apoptotic process	IDA	25339672
cellular response to interferon-alpha	IDA	25339672

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte mediated immunity [inference]

myeloid leukocyte mediated immunity [inference]

neutrophil mediated immunity

immune response

leukocyte activation [inference]

myeloid leukocyte activation [inference]

granulocyte activation [inference]

neutrophil activation

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

myeloid leukocyte activation [inference]

granulocyte activation [inference]

neutrophil activation

signal transduction [inference]

immune response-regulating signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

Fc receptor signaling pathway

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

Fc receptor signaling pathway

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

cellular response to biotic stimulus [inference]

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

myeloid leukocyte activation [inference]

granulocyte activation [inference]

neutrophil activation

response to stimulus [inference]

immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

cellular response to biotic stimulus [inference]

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

response to chemical [inference]

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

response to lipid [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

cellular response to lipid [inference]

cellular response to lipopolysaccharide

response to cytokine [inference]

response to type II interferon [inference]

cellular response to type II interferon

response to tumor necrosis factor [inference]

cellular response to tumor necrosis factor

response to interferon-alpha [inference]

cellular response to interferon-alpha

response to interleukin-6 [inference]

cellular response to interleukin-6

cellular response to cytokine stimulus [inference]

response to granulocyte macrophage colony-stimulating factor [inference]

cellular response to granulocyte macrophage colony-stimulating factor stimulus

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

response to oxygen-containing compound [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

cellular response to biotic stimulus [inference]

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of neutrophil apoptotic process

regulation of neutrophil apoptotic process [inference]

positive regulation of neutrophil apoptotic process

regulation of immune response [inference]

immune response-regulating signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

Fc receptor signaling pathway

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of neutrophil apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of myeloid cell apoptotic process [inference]

positive regulation of neutrophil apoptotic process

positive regulation of leukocyte apoptotic process [inference]

positive regulation of neutrophil apoptotic process

regulation of response to stimulus [inference]

regulation of immune response [inference]

immune response-regulating signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

Fc receptor signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

immune response-regulating signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

Fc receptor signaling pathway

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

Fc receptor signaling pathway

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of myeloid cell apoptotic process [inference]

regulation of neutrophil apoptotic process [inference]

positive regulation of neutrophil apoptotic process

positive regulation of myeloid cell apoptotic process [inference]

positive regulation of neutrophil apoptotic process

positive regulation of apoptotic process [inference]

positive regulation of myeloid cell apoptotic process [inference]

positive regulation of neutrophil apoptotic process

positive regulation of leukocyte apoptotic process [inference]

positive regulation of neutrophil apoptotic process

regulation of leukocyte apoptotic process [inference]

regulation of neutrophil apoptotic process [inference]

positive regulation of neutrophil apoptotic process

positive regulation of leukocyte apoptotic process [inference]

positive regulation of neutrophil apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of myeloid cell apoptotic process [inference]

positive regulation of neutrophil apoptotic process

positive regulation of leukocyte apoptotic process [inference]

positive regulation of neutrophil apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of myeloid cell apoptotic process [inference]

positive regulation of neutrophil apoptotic process

positive regulation of leukocyte apoptotic process [inference]

positive regulation of neutrophil apoptotic process

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
extracellular region	IEA
plasma membrane	TAS
plasma membrane	IDA	25339672
plasma membrane	IBA
specific granule membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane [inference]

bounding membrane of organelle [inference]

secretory granule membrane [inference]

Displaying **all 3** entries
GO Term	Evidence Code	PMID
IgA receptor activity	IDA	25339672
IgA binding	IDA	25339672
IgA binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein-containing complex binding [inference]

immunoglobulin binding [inference]

IgA binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

immunoglobulin receptor activity [inference]

IgA receptor activity

immune receptor activity [inference]

immunoglobulin receptor activity [inference]

IgA receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Immunoglobulin alpha Fc receptor

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
V: Defense mechanisms

Displaying 1 entry
InterPro
Immunoglobulin

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0050855	renal fibrosis	Alliance of Genome Resources
DOID:12132	granulomatosis with polyangiitis	Alliance of Genome Resources
DOID:2986	IgA glomerulonephritis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 24 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	1	Xenbase:XB-GENE-6464634
Xenopus tropicalis	2204	Xenbase:XB-GENE-6464634
Xenopus tropicalis	232790	Xenbase:XB-GENE-6464634
Xenopus tropicalis	245126	Xenbase:XB-GENE-6464634
Pan troglodytes	469107		PANTR19351
Bos taurus	503555		BOVIN11880
Macaca mulatta	664734		MACMU19332
Equus caballus	100050205		HORSE01928
Equus caballus	100054918		HORSE01928
Sus scrofa	100144539		PIGXX28548