granulomatosis with polyangiitis

Summary
Synonym
  • Necrotizing respiratory granulomatosis
  • Wegener granulomatosis, formerly
Definition
An autoimmune disease that is characterized by necrotizing granulomatous inflammation of the upper and lower respiratory tract, glomerulonephritis, vasculitis, and the presence of antineutrophil cytoplasmatic autoantibodies (ANCAs) in patient sera, and is located_in lung, located_in kidney, located_in skin resulting from an autoimmune attack by antineutrophil cytoplasmic antibodies against small and medium-size blood vessels.
Super Class
autoimmune disease of blood kidney disease lung disease skin disease
Disease Ontology
DOID:12132
Mondo Disease Ontology
MeSH
UMLS
NCI Thesaurus
OMIM
GARD
Related Genes
Displaying all 9 entries
Gene ID Gene Symbol Description Source
948 CD36 CD36 molecule (CD36 blood group)
959 CD40LG CD40 ligand
1232 CCR3 C-C motif chemokine receptor 3
1234 CCR5 C-C motif chemokine receptor 5
1493 CTLA4 cytotoxic T-lymphocyte associated protein 4
2204 FCAR Fc alpha receptor
3586 IL10 interleukin 10
7056 THBD thrombomodulin
7448 VTN vitronectin
Displaying all 7 entries
Gene ID Gene Symbol Description Source
12477 Ctla4 cytotoxic T-lymphocyte-associated protein 4
12491 Cd36 CD36 molecule
12774 Ccr5 C-C motif chemokine receptor 5
16153 Il10 interleukin 10
21824 Thbd thrombomodulin
21947 Cd40lg CD40 ligand
22370 Vtn vitronectin
Displaying all 3 entries
Gene ID Gene Symbol Description Source
25325 Il10 interleukin 10
84349 Cd40lg CD40 ligand
117029 Ccr5 C-C motif chemokine receptor 5
Displaying 1 entry
Gene ID Gene Symbol Description Source
38868 Snmp2 Sensory neuron membrane protein 2
Displaying all 3 entries
Gene ID Gene Symbol Description Source
176673 scav-3 Sensory neuron membrane protein 2
176787 scav-2 SCAVenger receptor (CD36 family) related
180836 W01C8.5 DM13 domain-containing protein

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: December 9, 2024