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cytotoxic T-lymphocyte associated protein 4

Summary

Gene Symbol

CTLA4

Organism

Homo sapiens (human)

External Links

NCBI Gene

1493

PubChem

1493

Alliance of Genome Resources

HGNC:2505

Annotation

Keyword

3D-structure
Adaptive immunity
Alternative splicing
Cell membrane
Diabetes mellitus
Disease variant
Disulfide bond
Glycoprotein
Immunoglobulin domain
Pharmaceutical
Phosphoprotein
Proteomics identification
Reference proteome
Signal
Systemic lupus erythematosus
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P16410	Cytotoxic T-lymphocyte-associated antigen 4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
adaptive immune response	IEA
immune response	TAS	3220103
DNA damage response	IMP	17875758
cellular response to DNA damage stimulus	IMP	17875758
negative regulation of B cell proliferation	IMP	17875758

GO Hierarchy

biological process

immune system process [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

immune response

adaptive immune response

cellular process [inference]

signal transduction [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

immune response

adaptive immune response

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

regulation of lymphocyte activation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of regulatory T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of lymphocyte proliferation [inference]

regulation of B cell proliferation [inference]

negative regulation of B cell proliferation

regulation of T cell proliferation [inference]

negative regulation of T cell proliferation

negative regulation of lymphocyte proliferation [inference]

regulation of T cell activation [inference]

regulation of T cell proliferation [inference]

negative regulation of T cell proliferation

regulation of T cell differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of regulatory T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of B cell activation [inference]

regulation of B cell proliferation [inference]

negative regulation of B cell proliferation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of regulatory T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of cell population proliferation [inference]

negative regulation of leukocyte proliferation [inference]

negative regulation of mononuclear cell proliferation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of multicellular organismal process [inference]

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

regulation of developmental process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of regulatory T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of regulatory T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of cellular process [inference]

signal transduction [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

regulation of cell adhesion [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of cell-cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of leukocyte cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of leukocyte proliferation [inference]

negative regulation of mononuclear cell proliferation [inference]

negative regulation of lymphocyte proliferation [inference]

regulation of leukocyte proliferation [inference]

regulation of mononuclear cell proliferation [inference]

negative regulation of mononuclear cell proliferation [inference]

negative regulation of lymphocyte proliferation [inference]

regulation of lymphocyte proliferation [inference]

regulation of B cell proliferation [inference]

negative regulation of B cell proliferation

regulation of T cell proliferation [inference]

negative regulation of T cell proliferation

negative regulation of lymphocyte proliferation [inference]

negative regulation of leukocyte proliferation [inference]

negative regulation of mononuclear cell proliferation [inference]

negative regulation of lymphocyte proliferation [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of regulatory T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of cell population proliferation [inference]

negative regulation of leukocyte proliferation [inference]

negative regulation of mononuclear cell proliferation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

regulation of lymphocyte activation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of regulatory T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of lymphocyte proliferation [inference]

regulation of B cell proliferation [inference]

negative regulation of B cell proliferation

regulation of T cell proliferation [inference]

negative regulation of T cell proliferation

negative regulation of lymphocyte proliferation [inference]

regulation of T cell activation [inference]

regulation of T cell proliferation [inference]

negative regulation of T cell proliferation

regulation of T cell differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of regulatory T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of B cell activation [inference]

regulation of B cell proliferation [inference]

negative regulation of B cell proliferation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

regulation of lymphocyte activation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of regulatory T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of lymphocyte proliferation [inference]

regulation of B cell proliferation [inference]

negative regulation of B cell proliferation

regulation of T cell proliferation [inference]

negative regulation of T cell proliferation

negative regulation of lymphocyte proliferation [inference]

regulation of T cell activation [inference]

regulation of T cell proliferation [inference]

negative regulation of T cell proliferation

regulation of T cell differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of regulatory T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of B cell activation [inference]

regulation of B cell proliferation [inference]

negative regulation of B cell proliferation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

negative regulation of multicellular organismal process [inference]

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of regulatory T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
Golgi apparatus	IDA	15814706
plasma membrane	TAS
plasma membrane	IMP	28484017
external side of plasma membrane	IDA	18641304
external side of plasma membrane	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

protein complex involved in cell adhesion

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle [inference]

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle [inference]

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle [inference]

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

perinuclear region of cytoplasm

side of membrane [inference]

external side of plasma membrane

Displaying 1 entry
GO Term	Evidence Code	PMID
protein binding	IPI	11279501 11279502 20587542 21982860 25241761 26206937 32296183 33961781 7807015 9398332 9813138

GO Hierarchy

molecular function

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Cytotoxic T-lymphocyte protein 4

Functional Category

C: Energy production and conversion
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
B cell receptor signaling pathway
T cell receptor signaling pathway
adaptive immune response
immune response
immune system process
negative regulation of regulatory T cell differentiation
regulation of T cell proliferation

Displaying **all 6** entries
InterPro
Cytotoxic T-lymphocyte antigen 4
Cytotoxic T-lymphocyte protein 4/CD28
Immunoglobulin V-set domain
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like fold

Disease

Disease Ontology

Displaying entries **1 - 10** of 43 in total

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DO ID	Disease Name	Source
DOID:0060025	immunoglobulin alpha deficiency	Alliance of Genome Resources
DOID:0060060	non-Hodgkin lymphoma	Alliance of Genome Resources
DOID:0080162	lupus nephritis	Alliance of Genome Resources
DOID:0080846	latent autoimmune diabetes in adults	Alliance of Genome Resources
DOID:0081120	Graves ophthalmopathy	Alliance of Genome Resources
DOID:0081267	graft-versus-host disease	Alliance of Genome Resources
DOID:0110751	type 1 diabetes mellitus 12	Alliance of Genome Resources
DOID:10608	celiac disease	Alliance of Genome Resources
DOID:11335	sarcoidosis	Alliance of Genome Resources
DOID:12132	granulomatosis with polyangiitis	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements