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unc-5 netrin receptor C

Summary

Gene Symbol

Unc5c

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

22253

PubChem

22253

Alliance of Genome Resources

MGI:1095412

Annotation

Keyword

Alternative splicing
Apoptosis
Cell membrane
Cell projection
Developmental protein
Disulfide bond
Glycoprotein
Immunoglobulin domain
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Synaptosome
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
O08747	Protein unc-5 homolog 3 Protein unc-5 homolog C Rostral cerebellar malformation protein
Q3UQ08
Q3URW2

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
apoptotic process	IMP	18077458
axon guidance	IDA	22685302
axon guidance	IGI	22685302 23144223
axon guidance	IBA
brain development	IMP	10818148 1401878 9126743 9550145

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

netrin-activated signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process

programmed cell death involved in cell development [inference]

ectopic germ cell programmed cell death

cellular developmental process [inference]

programmed cell death involved in cell development [inference]

ectopic germ cell programmed cell death

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

anterior/posterior axon guidance

reproductive process [inference]

developmental process involved in reproduction [inference]

ectopic germ cell programmed cell death

developmental process [inference]

developmental process involved in reproduction [inference]

ectopic germ cell programmed cell death

anatomical structure development [inference]

tissue development [inference]

ganglion development [inference]

dorsal root ganglion development

animal organ development [inference]

brain development

cellular developmental process [inference]

programmed cell death involved in cell development [inference]

ectopic germ cell programmed cell death

locomotion [inference]

taxis [inference]

chemotaxis [inference]

negative chemotaxis [inference]

chemorepulsion of axon

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

regulation of cell motility [inference]

regulation of cell migration

regulation of neuron migration

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of developmental process [inference]

positive regulation of developmental process

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

netrin-activated signaling pathway

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of cell motility [inference]

regulation of cell migration

regulation of neuron migration

regulation of reproductive process [inference]

positive regulation of reproductive process

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GO Term	Evidence Code	PMID
plasma membrane	ISO
plasma membrane	TAS
plasma membrane	IDA	10964959
cell surface	IEA
lamellipodium	IDA	28483977

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell surface

membrane [inference]

plasma membrane

cell junction [inference]

synapse

site of polarized growth [inference]

growth cone

cell projection [inference]

plasma membrane bounded cell projection [inference]

lamellipodium

neuron projection [inference]

actin-based cell projection [inference]

filopodium

cell body [inference]

neuronal cell body

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GO Term	Evidence Code	PMID
netrin receptor activity	IDA	10964959
netrin receptor activity	IBA
netrin receptor activity involved in chemorepulsion	IDA	22685302 28483977
protein binding	IPI	10964959 22685302 28483977
tubulin binding	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

tubulin binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

netrin receptor activity

netrin receptor activity involved in chemorepulsion

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

unc-5 netrin receptor A

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 2** entries
Gene Ontology
netrin receptor activity
netrin-activated signaling pathway

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InterPro
Death domain
Death-like domain superfamily
Immunoglobulin I-set
Immunoglobulin subtype 2
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold
Netrin receptor UNC5
Thrombospondin type-1 (TSP1) repeat superfamily

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	8633	Xenbase:XB-GENE-921628	HUMAN76629
Xenopus tropicalis	22253	Xenbase:XB-GENE-921628
Xenopus tropicalis	36703	Xenbase:XB-GENE-921628
Drosophila melanogaster	60629	FB:FBgn0034013
Drosophila melanogaster	60630	FB:FBgn0034013
Drosophila melanogaster	90249	FB:FBgn0034013
Drosophila melanogaster	107448	FB:FBgn0034013
Drosophila melanogaster	107449	FB:FBgn0034013
Drosophila melanogaster	137970	FB:FBgn0034013
Xenopus tropicalis	177334	Xenbase:XB-GENE-921628

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