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Von Willebrand factor

Summary

Gene Symbol

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

22371

PubChem

22371

Alliance of Genome Resources

MGI:98941

Annotation

Keyword

3D-structure
Alternative splicing
Blood coagulation
Cell adhesion
Cleavage on pair of basic residues
Disulfide bond
Extracellular matrix
Glycoprotein
Proteomics identification
Reference proteome
Repeat
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
E9QPU1
Q8CIZ8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	PMID
liver development	IMP	7854452
placenta development	IMP	7854452
activation of blood coagulation via clotting cascade	IDA	30573509
inflammatory response	IDA	30573509
cell adhesion	ISS

GO Hierarchy

biological process

cellular process [inference]

cell activation [inference]

platelet activation

cell adhesion

cell-substrate adhesion

multicellular organismal process [inference]

cell activation [inference]

platelet activation

coagulation [inference]

blood coagulation

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

placenta development

gland development [inference]

liver development

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

regulation of intracellular signal transduction [inference]

positive regulation of intracellular signal transduction

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

positive regulation of response to wounding [inference]

positive regulation of wound healing [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

positive regulation of multicellular organismal process [inference]

positive regulation of coagulation [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

positive regulation of hemostasis [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

regulation of intracellular signal transduction [inference]

positive regulation of intracellular signal transduction

regulation of response to external stimulus [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

positive regulation of response to wounding [inference]

positive regulation of wound healing [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

regulation of response to stress [inference]

regulation of response to wounding [inference]

regulation of wound healing [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

positive regulation of wound healing [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

positive regulation of response to wounding [inference]

positive regulation of wound healing [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

regulation of intracellular signal transduction [inference]

positive regulation of intracellular signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

regulation of multicellular organismal process [inference]

regulation of coagulation [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

positive regulation of coagulation [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

positive regulation of multicellular organismal process [inference]

positive regulation of coagulation [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

positive regulation of hemostasis [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

regulation of biological quality [inference]

regulation of body fluid levels [inference]

hemostasis

blood coagulation

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

positive regulation of hemostasis [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
extracellular region	ISS
extracellular region	ISO
extracellular space	ISO
extracellular space	IDA	30573509
extracellular space	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix

collagen-containing extracellular matrix

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle [inference]

Weibel-Palade body

secretory vesicle [inference]

secretory granule [inference]

Weibel-Palade body

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle [inference]

Weibel-Palade body

secretory vesicle [inference]

secretory granule [inference]

Weibel-Palade body

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle [inference]

Weibel-Palade body

secretory vesicle [inference]

secretory granule [inference]

Weibel-Palade body

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
protease binding	ISS
protease binding	ISO
integrin binding	ISS
integrin binding	ISO
extracellular matrix structural constituent	RCA	22159717 28071719

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent

binding [inference]

protein binding

signaling receptor binding [inference]

integrin binding

enzyme binding [inference]

protease binding

identical protein binding

cell adhesion molecule binding [inference]

integrin binding

protein-folding chaperone binding

protein-containing complex binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

von willebrand factor

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
blood coagulation
cell-substrate adhesion

Displaying **all 3** entries
InterPro
Serine protease inhibitor-like superfamily
Trypsin Inhibitor-like, cysteine rich domain
VWF/SSPO/Zonadhesin-like, cysteine-rich domain

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060574	von Willebrand's disease 2	Alliance of Genome Resources
DOID:12531	von Willebrand's disease	Alliance of Genome Resources

Ortholog

Displaying entries **41 - 50** of 76 in total

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Species	Gene ID	Orthologous MAtrix
Pelodiscus sinensis	102446530	PELSI06834
Ornithorhynchus anatinus	103166232	ORNAN31325
Callorhinchus milii	103185564	CALMI32595
Chlorocebus sabaeus	103218442	CHLSB01854
Ursus maritimus	103656237	URSMA29022
Nannospalax galili	103727534	NANGA05271
Serinus canaria	103819672	SERCA14990
Rhinopithecus roxellana	104680130	RHIRO25472
Pteropus vampyrus	105296024	PTEVA13520
Macaca nemestrina	105484247	MACNE35480