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dual-specificity tyrosine phosphorylation regulated kinase 3

Summary

Gene Symbol

Dyrk3

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

226419

PubChem

226419

Alliance of Genome Resources

MGI:1330300

Annotation

Keyword

ATP-binding
Cytoskeleton
Magnesium
Metal-binding
Mitosis
Nucleus
Phosphoprotein
Reference proteome
Serine/threonine-protein kinase
Tyrosine-protein kinase
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q922Y0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	PMID
protein phosphorylation	ISO
protein phosphorylation	IDA	12356771
peptidyl-tyrosine phosphorylation	ISO	9748265
erythrocyte differentiation	ISO
erythrocyte differentiation	IDA	16524748

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

peptidyl-tyrosine phosphorylation

peptidyl-amino acid modification [inference]

peptidyl-tyrosine modification [inference]

peptidyl-tyrosine phosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

peptidyl-tyrosine phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

peptidyl-tyrosine phosphorylation

peptidyl-amino acid modification [inference]

peptidyl-tyrosine modification [inference]

peptidyl-tyrosine phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

peptidyl-tyrosine phosphorylation

peptidyl-amino acid modification [inference]

peptidyl-tyrosine modification [inference]

peptidyl-tyrosine phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

peptidyl-tyrosine phosphorylation

peptidyl-amino acid modification [inference]

peptidyl-tyrosine modification [inference]

peptidyl-tyrosine phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

peptidyl-tyrosine phosphorylation

peptidyl-amino acid modification [inference]

peptidyl-tyrosine modification [inference]

peptidyl-tyrosine phosphorylation

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

peptidyl-tyrosine phosphorylation

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation [inference]

erythrocyte differentiation

cell division

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

nucleus organization [inference]

nuclear body organization [inference]

nuclear speck organization

organelle disassembly

stress granule disassembly

cellular component disassembly [inference]

protein-containing complex disassembly [inference]

protein-RNA complex disassembly [inference]

stress granule disassembly

organelle disassembly

stress granule disassembly

protein-containing complex organization [inference]

protein-containing complex disassembly [inference]

protein-RNA complex disassembly [inference]

stress granule disassembly

protein-RNA complex organization [inference]

protein-RNA complex disassembly [inference]

stress granule disassembly

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation [inference]

erythrocyte differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of signal transduction by p53 class mediator [inference]

negative regulation of DNA damage response, signal transduction by p53 class mediator

regulation of intracellular signal transduction [inference]

regulation of TOR signaling [inference]

regulation of TORC1 signaling

regulation of signal transduction by p53 class mediator [inference]

regulation of DNA damage response, signal transduction by p53 class mediator [inference]

negative regulation of DNA damage response, signal transduction by p53 class mediator

negative regulation of signal transduction by p53 class mediator [inference]

negative regulation of DNA damage response, signal transduction by p53 class mediator

negative regulation of intracellular signal transduction [inference]

negative regulation of signal transduction by p53 class mediator [inference]

negative regulation of DNA damage response, signal transduction by p53 class mediator

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of signal transduction by p53 class mediator [inference]

negative regulation of DNA damage response, signal transduction by p53 class mediator

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of cell cycle G2/M phase transition

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of signal transduction by p53 class mediator [inference]

negative regulation of DNA damage response, signal transduction by p53 class mediator

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of signal transduction by p53 class mediator [inference]

negative regulation of DNA damage response, signal transduction by p53 class mediator

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of signal transduction by p53 class mediator [inference]

negative regulation of DNA damage response, signal transduction by p53 class mediator

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of signal transduction by p53 class mediator [inference]

negative regulation of DNA damage response, signal transduction by p53 class mediator

regulation of intracellular signal transduction [inference]

regulation of TOR signaling [inference]

regulation of TORC1 signaling

regulation of signal transduction by p53 class mediator [inference]

regulation of DNA damage response, signal transduction by p53 class mediator [inference]

negative regulation of DNA damage response, signal transduction by p53 class mediator

negative regulation of signal transduction by p53 class mediator [inference]

negative regulation of DNA damage response, signal transduction by p53 class mediator

negative regulation of intracellular signal transduction [inference]

negative regulation of signal transduction by p53 class mediator [inference]

negative regulation of DNA damage response, signal transduction by p53 class mediator

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of signal transduction by p53 class mediator [inference]

negative regulation of DNA damage response, signal transduction by p53 class mediator

regulation of response to stress [inference]

regulation of cellular response to stress

regulation of DNA damage response, signal transduction by p53 class mediator [inference]

negative regulation of DNA damage response, signal transduction by p53 class mediator

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of signal transduction by p53 class mediator [inference]

negative regulation of DNA damage response, signal transduction by p53 class mediator

regulation of intracellular signal transduction [inference]

regulation of TOR signaling [inference]

regulation of TORC1 signaling

regulation of signal transduction by p53 class mediator [inference]

regulation of DNA damage response, signal transduction by p53 class mediator [inference]

negative regulation of DNA damage response, signal transduction by p53 class mediator

negative regulation of signal transduction by p53 class mediator [inference]

negative regulation of DNA damage response, signal transduction by p53 class mediator

negative regulation of intracellular signal transduction [inference]

negative regulation of signal transduction by p53 class mediator [inference]

negative regulation of DNA damage response, signal transduction by p53 class mediator

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of signal transduction by p53 class mediator [inference]

negative regulation of DNA damage response, signal transduction by p53 class mediator

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of cell cycle G2/M phase transition

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of signal transduction by p53 class mediator [inference]

negative regulation of DNA damage response, signal transduction by p53 class mediator

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of cell cycle G2/M phase transition

regulation of cell cycle phase transition [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of cell cycle G2/M phase transition

regulation of cell cycle G2/M phase transition [inference]

positive regulation of cell cycle G2/M phase transition

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of cell cycle G2/M phase transition

regulation of cellular response to stress

regulation of DNA damage response, signal transduction by p53 class mediator [inference]

negative regulation of DNA damage response, signal transduction by p53 class mediator

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
pericentriolar material	ISS
pericentriolar material	ISO
nucleus	ISS
nucleus	ISO
nucleus	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nuclear body [inference]

nuclear speck

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

cytoplasmic stress granule

intracellular organelle [inference]

intracellular membrane-bounded organelle

nucleus

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

cytoplasmic stress granule

supramolecular complex [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

cytoplasmic stress granule

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
magnesium ion binding	ISO
magnesium ion binding	IDA	12356771
protein kinase activity	ISO
protein kinase activity	IDA	12356771
protein serine/threonine kinase activity	ISS

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity

protein tyrosine kinase activity

histone kinase activity [inference]

histone H3 kinase activity [inference]

histone H3Y41 kinase activity

histone H2AX kinase activity [inference]

histone H2AXY142 kinase activity

protein serine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

protein tyrosine kinase activity

histone kinase activity [inference]

histone H3 kinase activity [inference]

histone H3Y41 kinase activity

histone H2AX kinase activity [inference]

histone H2AXY142 kinase activity

protein serine kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity

protein tyrosine kinase activity

histone kinase activity [inference]

histone H3 kinase activity [inference]

histone H3Y41 kinase activity

histone H2AX kinase activity [inference]

histone H2AXY142 kinase activity

protein serine kinase activity

histone modifying activity [inference]

histone kinase activity [inference]

histone H3 kinase activity [inference]

histone H3Y41 kinase activity

histone H2AX kinase activity [inference]

histone H2AXY142 kinase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

dual specificity tyrosine phosphorylation regulated kinase 3

Functional Category

G: Carbohydrate transport and metabolism
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
ATP binding
kinase activity
nucleotide binding
phosphorylation
positive regulation of cell cycle G2/M phase transition
protein serine/threonine/tyrosine kinase activity
stress granule disassembly

Displaying **all 5** entries
InterPro
Dual specificity tyrosine-phosphorylation-regulated kinase
Protein kinase domain
Protein kinase, ATP binding site
Protein kinase-like domain superfamily
Serine/threonine-protein kinase, active site

Ortholog

Displaying entries **1 - 10** of 69 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	8444		HUMAN54468
Xenopus tropicalis	226419	Xenbase:XB-GENE-1008699
Rattus norvegicus	304775		RATNO06656
Pan troglodytes	469142		PANTR23527
Bos taurus	505149		BOVIN07920
Macaca mulatta	695163		MACMU25425
Danio rerio	853300	ZFIN:ZDB-GENE-080219-31
Monodelphis domestica	100014844		MONDO15999
Equus caballus	100055466		HORSE33798
Ornithorhynchus anatinus	100087538		ORNAN24252

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