GlyCosmos Portal

Annotation

Keyword

ATP-binding
Alternative splicing
Cell projection
Coiled coil
Cytoplasm
Phosphoprotein
Proteomics identification
Reference proteome
Serine/threonine-protein kinase
Zinc-finger

Proteins

Displaying **all 3** entries
UniProt	Protein Name
H7BX44
E9PVY0
Q3UU96	CDC42-binding protein kinase alpha

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
regulation of small GTPase mediated signal transduction	ISO
actomyosin structure organization	IBA ISO
microtubule cytoskeleton organization	IMP	15882626
actin cytoskeleton organization	ISO
nuclear migration	IMP	15882626

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization

actin filament-based process [inference]

actin cytoskeleton organization

actomyosin structure organization

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

cell motility [inference]

cell migration

cellular localization [inference]

intracellular transport [inference]

nuclear migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization

microtubule cytoskeleton organization

actin cytoskeleton organization

actomyosin structure organization

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling

localization [inference]

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

nuclear migration

establishment of localization in cell [inference]

intracellular transport [inference]

nuclear migration

establishment of organelle localization [inference]

nuclear migration

organelle localization [inference]

nucleus localization [inference]

nuclear migration

establishment of organelle localization [inference]

nuclear migration

cellular localization [inference]

intracellular transport [inference]

nuclear migration

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
cell leading edge	ISO
lamellipodium	IDA	25107909
actomyosin	IBA ISO
cell-cell junction	ISO
cytoskeleton	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

cell junction [inference]

anchoring junction [inference]

cell-cell junction

cell projection [inference]

plasma membrane bounded cell projection [inference]

lamellipodium

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	25107909
protein serine kinase activity	IEA
metal ion binding	IEA
protein serine/threonine kinase activity	IBA ISO
identical protein binding	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

histone H2AS1 kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H2AS1 kinase activity

protein serine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

histone H2AS1 kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H2AS1 kinase activity

protein serine kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

histone H2AS1 kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H2AS1 kinase activity

protein serine kinase activity

histone modifying activity [inference]

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H2AS1 kinase activity

binding [inference]

protein binding

identical protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

magnesium ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

serine/threonine-protein kinase MRCK alpha

Functional Category

J: Translation, ribosomal structure and biogenesis
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
ATP binding
actomyosin structure organization
cytoskeleton organization
kinase activity
metal ion binding
nucleotide binding
phosphorylation
transferase activity

Displaying **all 4** entries
InterPro
Citron homology (CNH) domain
KELK-motif containing domain
Myotonic dystrophy protein kinase, coiled coil
Protein kinase domain

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060669	cerebral cavernous malformation	Alliance of Genome Resources
DOID:14227	azoospermia	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of **116** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Oreochromis niloticus	100695634		ORENI19225
Cavia porcellus	100732769	10141_0:003808	CAVPO07560
Cricetulus griseus	100750503	10029_0:0034ce
Otolemur garnettii	100959261		OTOGA04416
Pan paniscus	100976328		PANPA03913
Papio anubis	101004035		PAPAN21647
Saimiri boliviensis boliviensis	101050558		SAIBB17162
Felis catus	101088047		FELCA36674
Ovis aries	101114291		SHEEP03630
Gorilla gorilla gorilla	101138529		GORGO18007

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements