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ER membrane protein complex subunit 1

Summary

Gene Symbol

EMC1

Organism

Homo sapiens (human)

External Links

NCBI Gene

23065

PubChem

23065

Alliance of Genome Resources

HGNC:28957

Annotation

Keyword

3D-structure
Alternative splicing
Disease variant
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Neurodegeneration
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8N766

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein insertion into ER membrane by stop-transfer membrane-anchor sequence	IDA	29242231
protein insertion into ER membrane by stop-transfer membrane-anchor sequence	IMP	29809151 30415835
tail-anchored membrane protein insertion into ER membrane	IDA	29242231

GO Hierarchy

biological process

cellular process [inference]

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into ER membrane [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into ER membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into ER membrane [inference]

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into ER membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into ER membrane [inference]

establishment of localization [inference]

establishment of protein localization [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into ER membrane [inference]

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into ER membrane [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into ER membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into ER membrane [inference]

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	NAS	29242231
endoplasmic reticulum membrane	IDA	22119785 32439656
membrane	IDA	22119785
protein-containing complex	IDA	28246125
EMC complex	ISS

GO Hierarchy

cellular component

protein-containing complex

membrane protein complex [inference]

EMC complex

endoplasmic reticulum protein-containing complex [inference]

EMC complex

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	32353859 33060197 36217030
membrane insertase activity	IMP	29809151 30415835

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular carrier activity [inference]

protein carrier chaperone [inference]

membrane insertase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ER membrane protein complex subunit 1

Functional Category

L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
protein folding in endoplasmic reticulum

Displaying **all 5** entries
InterPro
ER membrane protein complex subunit 1, C-terminal
ER membrane protein complex subunit 1
Pyrrolo-quinoline quinone repeat
Quinoprotein alcohol dehydrogenase-like superfamily
WD40/YVTN repeat-like-containing domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0081276	cerebellar atrophy, visual impairment, and psychomotor retardation	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 87 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	23065	Xenbase:XB-GENE-1010282
Xenopus tropicalis	173524	Xenbase:XB-GENE-1010282
Mus musculus	230866	Xenbase:XB-GENE-1010282	MOUSE41655
Rattus norvegicus	362643	Xenbase:XB-GENE-1010282	RATNO33036
Xenopus tropicalis	431852	Xenbase:XB-GENE-1010282
Bos taurus	508439		BOVIN25340
Canis lupus familiaris	612432		CANLF07095
Macaca mulatta	702573		MACMU21596
Pan troglodytes	748745		PANTR20104
Xenopus tropicalis	850312	Xenbase:XB-GENE-1010282

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements