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ER membrane protein complex subunit 1

Summary

Gene Symbol

EMC1

Organism

Homo sapiens (human)

External Links

NCBI Gene

23065

PubChem

23065

Alliance of Genome Resources

HGNC:28957

Annotation

Keyword

3D-structure
Alternative splicing
Disease variant
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Neurodegeneration
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8N766

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein insertion into ER membrane by stop-transfer membrane-anchor sequence	IDA IMP	29242231 29809151 30415835
tail-anchored membrane protein insertion into ER membrane	IDA	29242231

GO Hierarchy

biological process

cellular process [inference]

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into ER membrane [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into ER membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into ER membrane [inference]

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into ER membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into ER membrane [inference]

establishment of localization [inference]

establishment of protein localization [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into ER membrane [inference]

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into ER membrane [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into ER membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into ER membrane [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein-containing complex	IDA	28246125
EMC complex	IBA IDA IPI ISS	22119785 32439656
membrane	IDA	22119785
endoplasmic reticulum membrane	IDA NAS	22119785 29242231 32439656

GO Hierarchy

cellular component

protein-containing complex

membrane protein complex [inference]

EMC complex

endoplasmic reticulum protein-containing complex [inference]

EMC complex

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	32353859 33060197 36217030
membrane insertase activity	IMP	29809151 30415835

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular carrier activity [inference]

protein carrier chaperone [inference]

membrane insertase activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0081276	cerebellar atrophy, visual impairment, and psychomotor retardation	Alliance of Genome Resources
DOID:10155	intestinal cancer	Alliance of Genome Resources