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structural maintenance of chromosomes 5

Summary

Gene Symbol

SMC5

Organism

Homo sapiens (human)

External Links

NCBI Gene

23137

PubChem

23137

Alliance of Genome Resources

HGNC:20465

Annotation

Keyword

ATP-binding
Coiled coil
DNA recombination
DNA repair
Disease variant
Mitosis
Nucleus
Phosphoprotein
Reference proteome
Telomere
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8IY18

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
telomere maintenance via recombination	IMP	17589526
double-strand break repair via homologous recombination	NAS	16810316
double-strand break repair via homologous recombination	IMP	16810316
double-strand break repair via homologous recombination	IBA
double-strand break repair via nonhomologous end joining	IMP	16810316

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

mitotic recombination [inference]

telomere maintenance via recombination

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein sumoylation

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

mitotic recombination [inference]

telomere maintenance via recombination

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

mitotic recombination [inference]

telomere maintenance via recombination

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

mitotic recombination [inference]

telomere maintenance via recombination

cellular senescence

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

mitotic recombination [inference]

telomere maintenance via recombination

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein sumoylation

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein sumoylation

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

macromolecule modification [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein sumoylation

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

mitotic recombination [inference]

telomere maintenance via recombination

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

mitotic recombination [inference]

telomere maintenance via recombination

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein sumoylation

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

cellular process [inference]

cell cycle process [inference]

chromosome segregation

cell cycle phase transition [inference]

mitotic cell cycle phase transition

mitotic cell cycle process [inference]

mitotic cell cycle phase transition

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

mitotic recombination [inference]

telomere maintenance via recombination

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

mitotic recombination [inference]

telomere maintenance via recombination

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

mitotic recombination [inference]

telomere maintenance via recombination

cellular senescence

cell division

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to chromosome, centromeric region

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

chromosome condensation

telomere organization [inference]

telomere maintenance [inference]

telomere maintenance via recombination

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin looping

multicellular organismal process [inference]

stem cell population maintenance

developmental process [inference]

maintenance of cell number [inference]

stem cell population maintenance

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with symbiont [inference]

modulation by host of symbiont process [inference]

modulation by host of viral process [inference]

negative regulation by host of viral process [inference]

negative regulation by host of viral genome replication

modulation by host of viral genome replication [inference]

negative regulation by host of viral genome replication

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to chromosome, centromeric region

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to chromosome, centromeric region

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of telomere maintenance

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of telomere maintenance

regulation of macromolecule metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of telomere maintenance

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of telomere maintenance

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

positive regulation of chromosome segregation

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of telomere maintenance

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

positive regulation of chromosome segregation

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

regulation of chromosome organization [inference]

regulation of sister chromatid cohesion [inference]

regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

regulation of maintenance of mitotic sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

regulation of telomere maintenance

positive regulation of chromosome organization [inference]

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

regulation of sister chromatid cohesion [inference]

regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

regulation of maintenance of mitotic sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

regulation of chromosome segregation [inference]

positive regulation of chromosome segregation

positive regulation of cell cycle process [inference]

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

positive regulation of chromosome segregation

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

positive regulation of chromosome segregation

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
chromosome, centromeric region	IEA
chromosome, telomeric region	NAS	17589526
chromosome, telomeric region	IDA	17589526
sex chromosome	ISS
nucleus	ISS

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

transferase complex [inference]

SUMO ligase complex [inference]

Smc5-Smc6 complex

cellular anatomical entity [inference]

nuclear body [inference]

cell junction

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

chromosome [inference]

sex chromosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

chromosome [inference]

sex chromosome

site of DNA damage [inference]

site of double-strand break

chromosomal region [inference]

Displaying **all 5** entries
GO Term	Evidence Code	PMID
DNA secondary structure binding	IDA	28095508
single-stranded DNA binding	IBA
protein binding	IPI	11408570 15601840 18086888 25931565 26496610 28514442 32296183 32389690 33961781 36373674
ATP binding	IEA
ATP hydrolysis activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

structural maintenance of

Functional Category

C: Energy production and conversion
L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 3** entries
Gene Ontology
ATP binding
DNA repair
nucleotide binding

Displaying **all 2** entries
InterPro
P-loop containing nucleoside triphosphate hydrolase
Structural maintenance of chromosomes protein 5

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080688	mosaic variegated aneuploidy syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 64 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus laevis	23137	Xenbase:XB-GENE-953075
Mus musculus	226026		MOUSE24870
Rattus norvegicus	293967		RATNO19738
Takifugu rubripes	445963		TAKRU36857
Pan troglodytes	464519		PANTR44085
Canis lupus familiaris	476327		CANLF00437
Bos taurus	508938		BOVIN34435
Danio rerio	566749		DANRE00828
Macaca mulatta	702219		MACMU12957
Equus caballus	100056086		HORSE22422

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements