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Guidelines

MIRAGE

mitogen-activated protein kinase 8 interacting protein 3

Summary

Gene Symbol

MAPK8IP3

Organism

Homo sapiens (human)

External Links

NCBI Gene

23162

PubChem

23162

Alliance of Genome Resources

HGNC:6884

Annotation

Keyword

3D-structure
Alternative splicing
Cell projection
Coiled coil
Cytoplasm
Cytoplasmic vesicle
Disease variant
Golgi apparatus
Intellectual disability
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying **all 4** entries
UniProt	Protein Name
Q9UPT6	JNK MAP kinase scaffold protein 3 Mitogen-activated protein kinase 8-interacting protein 3
B7ZMF3
E9PFH7
A0A087WYG2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
MAPK cascade	IEA
vesicle-mediated transport	ISS
vesicle-mediated transport	IBA
axon regeneration	ISS
negative regulation of apoptotic process	IMP	33022230

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

anterograde axonal transport [inference]

anterograde axonal protein transport

axo-dendritic protein transport [inference]

anterograde axonal protein transport

protein transport along microtubule [inference]

axo-dendritic protein transport [inference]

anterograde axonal protein transport

microtubule-based protein transport [inference]

protein transport along microtubule [inference]

axo-dendritic protein transport [inference]

anterograde axonal protein transport

signal transduction [inference]

intracellular signal transduction [inference]

MAPK cascade

vesicle-mediated transport

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein transport along microtubule [inference]

axo-dendritic protein transport [inference]

anterograde axonal protein transport

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

anterograde axonal transport [inference]

anterograde axonal protein transport

axo-dendritic protein transport [inference]

anterograde axonal protein transport

protein transport along microtubule [inference]

axo-dendritic protein transport [inference]

anterograde axonal protein transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein transport along microtubule [inference]

axo-dendritic protein transport [inference]

anterograde axonal protein transport

microtubule-based protein transport [inference]

protein transport along microtubule [inference]

axo-dendritic protein transport [inference]

anterograde axonal protein transport

protein localization to cell junction [inference]

protein localization to synapse [inference]

protein localization to presynapse [inference]

anterograde axonal protein transport

cellular response to stimulus [inference]

cellular response to stress [inference]

neuron projection regeneration [inference]

axon regeneration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection regeneration [inference]

axon regeneration

axon development

axon regeneration

developmental process [inference]

anatomical structure development [inference]

regeneration [inference]

neuron projection regeneration [inference]

axon regeneration

response to stimulus [inference]

response to stress [inference]

response to wounding [inference]

response to axon injury [inference]

axon regeneration

cellular response to stress [inference]

neuron projection regeneration [inference]

axon regeneration

cellular response to stimulus [inference]

cellular response to stress [inference]

neuron projection regeneration [inference]

axon regeneration

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein transport along microtubule [inference]

axo-dendritic protein transport [inference]

anterograde axonal protein transport

microtubule-based protein transport [inference]

protein transport along microtubule [inference]

axo-dendritic protein transport [inference]

anterograde axonal protein transport

protein localization to cell junction [inference]

protein localization to synapse [inference]

protein localization to presynapse [inference]

anterograde axonal protein transport

establishment of localization [inference]

transport [inference]

vesicle-mediated transport

intracellular transport [inference]

intracellular protein transport [inference]

protein transport along microtubule [inference]

axo-dendritic protein transport [inference]

anterograde axonal protein transport

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

anterograde axonal transport [inference]

anterograde axonal protein transport

axo-dendritic protein transport [inference]

anterograde axonal protein transport

protein transport along microtubule [inference]

axo-dendritic protein transport [inference]

anterograde axonal protein transport

organic substance transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein transport along microtubule [inference]

axo-dendritic protein transport [inference]

anterograde axonal protein transport

microtubule-based protein transport [inference]

protein transport along microtubule [inference]

axo-dendritic protein transport [inference]

anterograde axonal protein transport

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein transport along microtubule [inference]

axo-dendritic protein transport [inference]

anterograde axonal protein transport

microtubule-based protein transport [inference]

protein transport along microtubule [inference]

axo-dendritic protein transport [inference]

anterograde axonal protein transport

microtubule-based transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

anterograde axonal transport [inference]

anterograde axonal protein transport

axo-dendritic protein transport [inference]

anterograde axonal protein transport

protein transport along microtubule [inference]

axo-dendritic protein transport [inference]

anterograde axonal protein transport

microtubule-based protein transport [inference]

protein transport along microtubule [inference]

axo-dendritic protein transport [inference]

anterograde axonal protein transport

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein transport along microtubule [inference]

axo-dendritic protein transport [inference]

anterograde axonal protein transport

microtubule-based protein transport [inference]

protein transport along microtubule [inference]

axo-dendritic protein transport [inference]

anterograde axonal protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein transport along microtubule [inference]

axo-dendritic protein transport [inference]

anterograde axonal protein transport

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

anterograde axonal transport [inference]

anterograde axonal protein transport

axo-dendritic protein transport [inference]

anterograde axonal protein transport

protein transport along microtubule [inference]

axo-dendritic protein transport [inference]

anterograde axonal protein transport

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein transport along microtubule [inference]

axo-dendritic protein transport [inference]

anterograde axonal protein transport

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

anterograde axonal transport [inference]

anterograde axonal protein transport

axo-dendritic protein transport [inference]

anterograde axonal protein transport

protein transport along microtubule [inference]

axo-dendritic protein transport [inference]

anterograde axonal protein transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein transport along microtubule [inference]

axo-dendritic protein transport [inference]

anterograde axonal protein transport

microtubule-based protein transport [inference]

protein transport along microtubule [inference]

axo-dendritic protein transport [inference]

anterograde axonal protein transport

protein localization to cell junction [inference]

protein localization to synapse [inference]

protein localization to presynapse [inference]

anterograde axonal protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of JNK cascade

positive regulation of JNK cascade

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of JNK cascade

positive regulation of JNK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of JNK cascade

positive regulation of JNK cascade

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of JNK cascade

positive regulation of JNK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of JNK cascade

positive regulation of JNK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

MAPK cascade

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of JNK cascade

positive regulation of JNK cascade

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of JNK cascade

positive regulation of JNK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular response to stress [inference]

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of JNK cascade

positive regulation of JNK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of biological quality [inference]

regulation of protein stability [inference]

protein stabilization

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
Golgi membrane	ISS
cytoplasm	IBA
axon	ISS
dendrite	ISS
growth cone	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasmic region [inference]

plasma membrane bounded cell projection cytoplasm [inference]

neuron projection cytoplasm [inference]

axon cytoplasm

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

site of polarized growth [inference]

growth cone

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
MAP-kinase scaffold activity	ISS
MAP-kinase scaffold activity	IBA
protein binding	IPI	27107012 32296183 33961781
JUN kinase binding	IBA
kinesin binding	ISS

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

kinesin binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding [inference]

JUN kinase binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

signaling adaptor activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

C-Jun-amino-terminal kinase-interacting protein

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
JUN kinase binding
MAP-kinase scaffold activity
kinesin binding
signaling receptor complex adaptor activity

Displaying **all 6** entries
InterPro
JNK-interacting protein 3/4
JNK-interacting protein, leucine zipper II
JNK/Rab-associated protein-1, N-terminal
RH1 domain
RH2 domain
WD40/YVTN repeat-like-containing domain superfamily

Ortholog

Displaying entries **1 - 10** of 73 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	9043	FB:FBgn0024187
Xenopus laevis	23162	Xenbase:XB-GENE-6488639
Danio rerio	30957	ZFIN:ZDB-GENE-090303-6
Drosophila melanogaster	70834	FB:FBgn0024187
Rattus norvegicus	302983		RATNO01545
Pan troglodytes	453825		PANTR11427
Macaca mulatta	702388		MACMU26143
Monodelphis domestica	100010499		MONDO28375
Equus caballus	100067809		HORSE06963
Ornithorhynchus anatinus	100088393		ORNAN14002

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Last updated: December 8, 2025