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mesoderm development LRP chaperone

Summary

Gene Symbol

MESD

Organism

Homo sapiens (human)

External Links

NCBI Gene

23184

PubChem

23184

Alliance of Genome Resources

HGNC:13520

Annotation

Keyword

Alternative splicing
Chaperone
Disease variant
Endoplasmic reticulum
Glycoprotein
Osteogenesis imperfecta
Reference proteome
Signal
Wnt signaling pathway

Proteins

Displaying 1 entry
UniProt	Protein Name
Q14696	LDLR chaperone MESD Mesoderm development LRP chaperone MESD Mesoderm development candidate 2 Mesoderm development protein Renal carcinoma antigen NY-REN-61

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
protein folding	IMP ISS	31564437
positive regulation of skeletal muscle acetylcholine-gated channel clustering	ISS
protein localization to cell surface	ISS
phagocytosis	ISS
mesoderm development	NAS	11247670

GO Hierarchy

biological process

cellular process [inference]

protein folding

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell surface

multicellular organismal process [inference]

ossification

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

mesoderm development

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell surface

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis

import into cell [inference]

endocytosis [inference]

phagocytosis

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell surface

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to membrane [inference]

positive regulation of receptor clustering [inference]

positive regulation of skeletal muscle acetylcholine-gated channel clustering

regulation of protein localization to membrane [inference]

regulation of receptor clustering [inference]

positive regulation of receptor clustering [inference]

positive regulation of skeletal muscle acetylcholine-gated channel clustering

regulation of skeletal muscle acetylcholine-gated channel clustering [inference]

positive regulation of skeletal muscle acetylcholine-gated channel clustering

positive regulation of protein localization to membrane [inference]

positive regulation of receptor clustering [inference]

positive regulation of skeletal muscle acetylcholine-gated channel clustering

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to membrane [inference]

positive regulation of receptor clustering [inference]

positive regulation of skeletal muscle acetylcholine-gated channel clustering

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

positive regulation of cellular process [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to membrane [inference]

positive regulation of receptor clustering [inference]

positive regulation of skeletal muscle acetylcholine-gated channel clustering

regulation of cellular localization [inference]

regulation of protein localization [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to membrane [inference]

positive regulation of receptor clustering [inference]

positive regulation of skeletal muscle acetylcholine-gated channel clustering

regulation of protein localization to membrane [inference]

regulation of receptor clustering [inference]

positive regulation of receptor clustering [inference]

positive regulation of skeletal muscle acetylcholine-gated channel clustering

regulation of skeletal muscle acetylcholine-gated channel clustering [inference]

positive regulation of skeletal muscle acetylcholine-gated channel clustering

positive regulation of protein localization to membrane [inference]

positive regulation of receptor clustering [inference]

positive regulation of skeletal muscle acetylcholine-gated channel clustering

Displaying **all 2** entries
GO Term	Evidence Code	PMID
plasma membrane	IEA
endoplasmic reticulum	IMP	31564437

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	32296183 32814053
low-density lipoprotein particle receptor binding	IBA
identical protein binding	IEA
molecular_function	ND

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

lipoprotein particle receptor binding [inference]

low-density lipoprotein particle receptor binding

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

uncharacterized protein

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
low-density lipoprotein particle receptor binding

Displaying 1 entry
InterPro
LRP chaperone MESD

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0111849	osteogenesis imperfecta type 20	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 77 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	48986		FB:FBgn0004132
Mus musculus	67943		MGI:1891421	MOUSE51705
Caenorhabditis elegans	173908		WB:WBGene00017293
Rattus norvegicus	308796		RGD:1310344	RATNO18029
Pan troglodytes	453586	9598_0:003ddc		PANTR10972
Bos taurus	514610			BOVIN16505
Macaca mulatta	712993			MACMU40726
Xenopus laevis	734603		Xenbase:XB-GENE-940837
Danio rerio	791222		ZFIN:ZDB-GENE-070112-2142	DANRE41087
Monodelphis domestica	100013314			MONDO03188

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements