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mesoderm development LRP chaperone

Summary

Gene Symbol

MESD

Organism

Homo sapiens (human)

External Links

NCBI Gene

23184

PubChem

23184

Alliance of Genome Resources

HGNC:13520

Annotation

Keyword

Alternative splicing
Chaperone
Disease variant
Endoplasmic reticulum
Glycoprotein
Osteogenesis imperfecta
Reference proteome
Signal
Wnt signaling pathway

Proteins

Displaying 1 entry
UniProt	Protein Name
Q14696	LDLR chaperone MESD Mesoderm development LRP chaperone MESD Mesoderm development candidate 2 Mesoderm development protein Renal carcinoma antigen NY-REN-61

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
ossification	IMP	31564437
protein folding	ISS
protein folding	IMP	31564437
phagocytosis	ISS
mesoderm development	NAS	11247670

GO Hierarchy

biological process

cellular process [inference]

protein folding

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell surface

multicellular organismal process [inference]

ossification

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

mesoderm development

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell surface

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis

import into cell [inference]

endocytosis [inference]

phagocytosis

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell surface

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to membrane [inference]

positive regulation of receptor clustering [inference]

positive regulation of skeletal muscle acetylcholine-gated channel clustering

regulation of protein localization to membrane [inference]

regulation of receptor clustering [inference]

positive regulation of receptor clustering [inference]

positive regulation of skeletal muscle acetylcholine-gated channel clustering

regulation of skeletal muscle acetylcholine-gated channel clustering [inference]

positive regulation of skeletal muscle acetylcholine-gated channel clustering

positive regulation of protein localization to membrane [inference]

positive regulation of receptor clustering [inference]

positive regulation of skeletal muscle acetylcholine-gated channel clustering

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to membrane [inference]

positive regulation of receptor clustering [inference]

positive regulation of skeletal muscle acetylcholine-gated channel clustering

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

positive regulation of cellular process [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to membrane [inference]

positive regulation of receptor clustering [inference]

positive regulation of skeletal muscle acetylcholine-gated channel clustering

regulation of cellular localization [inference]

regulation of protein localization [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to membrane [inference]

positive regulation of receptor clustering [inference]

positive regulation of skeletal muscle acetylcholine-gated channel clustering

regulation of protein localization to membrane [inference]

regulation of receptor clustering [inference]

positive regulation of receptor clustering [inference]

positive regulation of skeletal muscle acetylcholine-gated channel clustering

regulation of skeletal muscle acetylcholine-gated channel clustering [inference]

positive regulation of skeletal muscle acetylcholine-gated channel clustering

positive regulation of protein localization to membrane [inference]

positive regulation of receptor clustering [inference]

positive regulation of skeletal muscle acetylcholine-gated channel clustering

Displaying **all 2** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IMP	31564437
plasma membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	32296183 32814053
identical protein binding	IEA
low-density lipoprotein particle receptor binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

lipoprotein particle receptor binding [inference]

low-density lipoprotein particle receptor binding

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

LDLR chaperone boca

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
low-density lipoprotein particle receptor binding

Displaying 1 entry
InterPro
LRP chaperone MESD

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0111849	osteogenesis imperfecta type 20	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 72 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	23184	Xenbase:XB-GENE-940834
Mus musculus	67943	Xenbase:XB-GENE-940834	MOUSE51705
Rattus norvegicus	308796	Xenbase:XB-GENE-940834	RATNO18029
Pan troglodytes	453586		PANTR10972
Bos taurus	514610		BOVIN16505
Macaca mulatta	712993		MACMU40726
Danio rerio	791222		DANRE41087
Monodelphis domestica	100013314		MONDO03188
Equus caballus	100067329		HORSE15104
Sus scrofa	100157638		PIGXX31815

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements