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tensin 2

Summary

Gene Symbol

TNS2

Organism

Homo sapiens (human)

External Links

NCBI Gene

23371

PubChem

23371

Alliance of Genome Resources

HGNC:19737

Annotation

Keyword

3D-structure
Alternative splicing
Cell junction
Cell membrane
Cytoplasm
Lipid-binding
Methylation
Phosphoprotein
Protein phosphatase
Reference proteome
SH2 domain
Ubl conjugation
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
Q63HR2	C1 domain-containing phosphatase and tensin homolog Tensin-like C1 domain-containing phosphatase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
kidney development	IEA
chromatin remodeling	IEA
negative regulation of cell population proliferation	IMP	16951145
response to muscle activity	IEA
cellular homeostasis	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation [inference]

peptidyl-tyrosine dephosphorylation

collagen metabolic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

protein dephosphorylation [inference]

peptidyl-tyrosine dephosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation [inference]

peptidyl-tyrosine dephosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation [inference]

peptidyl-tyrosine dephosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein dephosphorylation [inference]

peptidyl-tyrosine dephosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation [inference]

peptidyl-tyrosine dephosphorylation

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

protein dephosphorylation [inference]

peptidyl-tyrosine dephosphorylation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling

multicellular organismal process [inference]

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

kidney development

growth [inference]

developmental growth [inference]

multicellular organism growth

homeostatic process [inference]

response to stimulus [inference]

response to activity [inference]

response to muscle activity

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

regulation of insulin receptor signaling pathway [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

regulation of insulin receptor signaling pathway [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of cellular response to insulin stimulus [inference]

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

regulation of insulin receptor signaling pathway [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of cellular response to insulin stimulus [inference]

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cytoplasm	IEA
plasma membrane	IEA
focal adhesion	IDA	16951145 22019427
focal adhesion	IBA
focal adhesion	HDA	21423176

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
protein tyrosine phosphatase activity	IDA	23401856
protein tyrosine phosphatase activity	IBA
non-membrane spanning protein tyrosine phosphatase activity	IEA
protein binding	IPI	16273093 16951145 17190795 24728074 25416956 25814554 26871637 27107012 32296183
zinc ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity

histone phosphatase activity [inference]

histone H2AXY142 phosphatase activity

catalytic activity, acting on a protein [inference]

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity

histone phosphatase activity [inference]

histone H2AXY142 phosphatase activity

histone modifying activity [inference]

histone phosphatase activity [inference]

histone H2AXY142 phosphatase activity

binding [inference]

protein binding

enzyme binding [inference]

kinase binding

identical protein binding

lipid binding

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

tensin

Functional Category

K: Transcription
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
SH2 domain superfamily
SH2 domain
Tensin/EPS8 phosphotyrosine-binding domain

Ortholog

Displaying entries **1 - 10** of 66 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	7145	FB:FBgn0000244
Drosophila melanogaster	21961	FB:FBgn0000244
Xenopus tropicalis	23371	Xenbase:XB-GENE-988669
Xenopus tropicalis	41144	Xenbase:XB-GENE-988669
Drosophila melanogaster	64759	FB:FBgn0000244
Drosophila melanogaster	84951	FB:FBgn0000244
Mus musculus	209039	Xenbase:XB-GENE-988669	MOUSE16794
Rattus norvegicus	315326		RATNO38386
Drosophila melanogaster	319939	FB:FBgn0000244
Pan troglodytes	451927		PANTR05777