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SLIT-ROBO Rho GTPase activating protein 2

Summary

Gene Symbol

SRGAP2

Organism

Homo sapiens (human)

External Links

NCBI Gene

23380

PubChem

23380

Alliance of Genome Resources

HGNC:19751

Annotation

Keyword

3D-structure
Cell membrane
Cell projection
Chromosomal rearrangement
Coiled coil
Cytoplasm
Cytoplasmic vesicle
GTPase activation
Methylation
Neurogenesis
Nucleus
Phosphoprotein
Postsynaptic cell membrane
Proteomics identification
Reference proteome
SH3 domain

Proteins

Displaying **all 5** entries
UniProt	Protein Name
B7Z3G4
B4DFE5
B7ZM87
O75044	Formin-binding protein 2 Rho GTPase-activating protein 34
A0A075B7B5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
lamellipodium assembly involved in ameboidal cell migration	IMP	20810653
signal transduction	IEA
extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration	ISS
negative regulation of cell migration	IBA
substrate adhesion-dependent cell spreading	IMP	20810653

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration [inference]

extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration

cell adhesion [inference]

cell-substrate adhesion [inference]

substrate adhesion-dependent cell spreading

signal transduction

actin filament-based process [inference]

actin filament severing

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration [inference]

extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly [inference]

lamellipodium assembly involved in ameboidal cell migration

pseudopodium assembly [inference]

extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration

filopodium assembly

cell junction assembly [inference]

synapse assembly [inference]

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly [inference]

lamellipodium assembly involved in ameboidal cell migration

pseudopodium assembly [inference]

extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration

filopodium assembly

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

plasma membrane bounded cell projection organization [inference]

pseudopodium organization [inference]

pseudopodium assembly [inference]

extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration

lamellipodium organization [inference]

lamellipodium assembly [inference]

lamellipodium assembly involved in ameboidal cell migration

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly [inference]

lamellipodium assembly involved in ameboidal cell migration

pseudopodium assembly [inference]

extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration

filopodium assembly

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly [inference]

synapse organization [inference]

synapse assembly [inference]

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

anatomical structure development [inference]

dendritic spine development

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of neuron migration

regulation of cell motility [inference]

regulation of cell migration [inference]

negative regulation of cell migration

negative regulation of neuron migration

regulation of neuron migration [inference]

negative regulation of neuron migration

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of neuron migration

negative regulation of biological process [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of neuron migration

negative regulation of cellular process [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of neuron migration

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

regulation of cellular process [inference]

signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly

negative regulation of cellular process [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of neuron migration

regulation of cellular component organization [inference]

regulation of synapse organization [inference]

regulation of synapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly

regulation of cell motility [inference]

regulation of cell migration [inference]

negative regulation of cell migration

negative regulation of neuron migration

regulation of neuron migration [inference]

negative regulation of neuron migration

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of neuron migration

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

regulation of hydrolase activity [inference]

regulation of GTPase activity [inference]

positive regulation of GTPase activity

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
nucleus	IEA
cytoplasm	IBA
cytosol	ISS
cytosol	TAS
plasma membrane	IDA	21148482

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

lamellipodium

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle [inference]

phagocytic vesicle

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle [inference]

phagocytic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle [inference]

phagocytic vesicle

postsynaptic specialization [inference]

postsynaptic density

dendritic spine head

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
GTPase activator activity	TAS
GTPase activator activity	IDA	21148482 27373832
GTPase activator activity	IMP	20810653
protein binding	IPI	15161933 16318909 17500595 19807924 20810653 21148482 22559944 26365803 28514442 33961781 35271311 36931259
small GTPase binding	IDA	20810653 21148482

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding [inference]

GTPase binding [inference]

small GTPase binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

GTPase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

slit-robo rho gtpase-activating

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
negative regulation of cell migration

Displaying **all 7** entries
InterPro
AH/BAR domain superfamily
F-BAR domain
FCH domain
Rho GTPase activation protein
Rho GTPase-activating protein domain
SH3 domain
SH3-like domain superfamily

Ortholog

Displaying entries **1 - 10** of 53 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	393	WB:WBGene00006406
Caenorhabditis elegans	9901	WB:WBGene00006406
Mus musculus	14270	Xenbase:XB-GENE-5897849	MOUSE28651
Xenopus tropicalis	23380	Xenbase:XB-GENE-5897849
Caenorhabditis elegans	57522	WB:WBGene00006406
Caenorhabditis elegans	117600	WB:WBGene00006406
Caenorhabditis elegans	259302	WB:WBGene00006406
Rattus norvegicus	360840		RATNO06702
Pan troglodytes	457680		PANTR23512
Canis lupus familiaris	478949		CANLF14325