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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
two pore segment channel 2
Summary
- Gene Symbol
-
- Tpcn2
- Organism
- Mus musculus (house mouse)
Annotation
- Keyword
-
- Alternative splicing
- Calcium channel
- Endosome
- Glycoprotein
- Lysosome
- Reference proteome
- Repeat
- Transmembrane helix
- Voltage-gated channel
- Proteins
| UniProt | Protein Name |
|---|---|
| Q8BWC0 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| regulation of exocytosis | ||
| intracellular pH reduction | ||
| regulation of autophagy | ||
| calcium-mediated signaling | ||
| negative regulation of developmental pigmentation |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| monoatomic ion channel complex | ||
| late endosome membrane | ||
| lysosome | ||
| endolysosome membrane | ||
| endosome membrane |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| phosphatidylinositol-3,5-bisphosphate binding | ||
| calcium channel activity | ||
| identical protein binding | ||
| protein kinase binding | ||
| voltage-gated calcium channel activity |
GO Hierarchy
molecular function
transporter activity [inference]
transmembrane transporter activity [inference]
OrthoDB (Group)
- Group level
- Rodentia
- Group Name
- Two pore channel protein 2
- Functional Category
-
- C: Energy production and conversion
- E: Amino acid transport and metabolism
- J: Translation, ribosomal structure and biogenesis
- O: Posttranslational modification, protein turnover, chaperones
| InterPro |
|---|
| Ion transport domain |
| Two pore channel protein 2 |
| Voltage-dependent channel domain superfamily |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:10123 | pigmentation disease | |
| DOID:3454 | brain infarction |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 219931 | HGNC:20820 | HUMAN07760 | ||
| 309139 | 10116_1:0008ff | RGD:1311779 | RATNO19508 | |
| 483683 | CANLF05949 | |||
| 516679 | BOVIN23626 | |||
| 709391 | MACMU09022 | |||
| 747605 | PANTR03644 | |||
| 777614 | ZFIN:ZDB-GENE-061103-202 | DANRE41704 | ||
| 100074753 | ORNAN19074 | |||
| 100145482 | Xenbase:XB-GENE-971835 | |||
| 100227742 | TAEGU25954 |
