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two pore segment channel 2

Summary

Gene Symbol

Tpcn2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

233979

KEGG Gene ID

PubChem

233979

Alliance of Genome Resources

MGI:2385297

Annotation

Keyword

Alternative splicing
Calcium channel
Endosome
Glycoprotein
Lysosome
Reference proteome
Repeat
Transmembrane helix
Voltage-gated channel

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8BWC0	Two pore calcium channel protein 2 Voltage-dependent calcium channel protein TPC2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 33 in total

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GO Term	Evidence Code	PMID
ion transport	IEA
monoatomic ion transport	IEA
intracellular calcium ion homeostasis	ISO
intracellular calcium ion homeostasis	IEA
smooth muscle contraction	IMP

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

calcium-mediated signaling

intercellular transport [inference]

endosome to lysosome transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

release of sequestered calcium ion into cytosol

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis of virus by host cell

endosome to lysosome transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

cytosolic transport [inference]

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

intracellular lipid transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport [inference]

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization [inference]

lytic vacuole organization [inference]

lysosome organization

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

smooth muscle contraction

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

regulation of intracellular pH [inference]

intracellular pH reduction

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

regulation of intracellular pH [inference]

intracellular pH reduction

monoatomic cation homeostasis [inference]

regulation of pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

regulation of intracellular pH [inference]

intracellular pH reduction

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

regulation of intracellular pH [inference]

intracellular pH reduction

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

symbiont entry into host [inference]

symbiont entry into host cell [inference]

endocytosis involved in viral entry into host cell

receptor-mediated endocytosis of virus by host cell

response to stimulus [inference]

response to nutrient levels [inference]

response to nutrient [inference]

response to vitamin [inference]

response to vitamin D

response to chemical [inference]

response to nutrient [inference]

response to vitamin [inference]

response to vitamin D

response to lipid [inference]

response to vitamin D

response to oxygen-containing compound [inference]

response to vitamin D

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport [inference]

sodium ion transmembrane transport

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

lipid transport [inference]

sterol transport [inference]

cholesterol transport [inference]

intracellular cholesterol transport [inference]

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

intracellular sterol transport [inference]

intracellular cholesterol transport [inference]

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

intracellular lipid transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport [inference]

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

intercellular transport [inference]

endosome to lysosome transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

release of sequestered calcium ion into cytosol

organic hydroxy compound transport [inference]

sterol transport [inference]

cholesterol transport [inference]

intracellular cholesterol transport [inference]

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

intracellular sterol transport [inference]

intracellular cholesterol transport [inference]

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis of virus by host cell

endosome to lysosome transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

cytosolic transport [inference]

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

intracellular lipid transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport [inference]

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis of virus by host cell

establishment of localization in cell [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

cytosolic transport [inference]

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

intracellular lipid transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport [inference]

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

cytosolic transport [inference]

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

intracellular lipid transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport [inference]

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

biological regulation [inference]

regulation of pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

regulation of secretion by cell [inference]

regulation of exocytosis

regulation of vesicle-mediated transport [inference]

regulation of exocytosis

negative regulation of biological process [inference]

negative regulation of developmental pigmentation

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

calcium-mediated signaling

regulation of metabolic process [inference]

regulation of catabolic process [inference]

regulation of autophagy

regulation of vesicle-mediated transport [inference]

regulation of exocytosis

regulation of secretion by cell [inference]

regulation of exocytosis

regulation of pigmentation [inference]

regulation of developmental pigmentation [inference]

negative regulation of developmental pigmentation

regulation of biological quality [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

Displaying entries **11 - 15** of 21 in total

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GO Term	Evidence Code	PMID
endosome membrane	IEA
membrane	IEA
late endosome membrane	ISO
late endosome membrane	IEA
melanosome membrane	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex

cellular anatomical structure [inference]

cytosol

membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

pigment granule membrane [inference]

melanosome membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endolysosome membrane

endosome membrane

pigment granule membrane [inference]

melanosome membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Displaying entries **1 - 5** of 28 in total

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GO Term	Evidence Code	PMID
monoatomic ion channel activity	IEA
ion channel activity	IEA
voltage-gated calcium channel activity	ISS
voltage-gated calcium channel activity	IMP
calcium channel activity	ISO