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MIRAGE

gremlin 2, DAN family BMP antagonist

Summary

Gene Symbol

Grem2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

23893

PubChem

23893

Alliance of Genome Resources

MGI:1344367

Annotation

Keyword

3D-structure
Cytokine
Developmental protein
Disulfide bond
Glycoprotein
Heparin-binding
Reference proteome
Secreted
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
O88273	Cysteine knot superfamily 1, BMP antagonist 2 Protein related to DAN and cerberus
Q3TST1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

1

2

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GO Term	Evidence Code	PMID
embryonic body morphogenesis	IMP	23850456
cytokine-mediated signaling pathway	IMP	23850456
negative regulation of BMP signaling pathway	IMP	23063586
sequestering of BMP from receptor via BMP binding	IMP	23063586
sequestering of BMP from receptor via BMP binding	IBA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

dorsal/ventral pattern formation [inference]

determination of dorsal identity

developmental process [inference]

anatomical structure morphogenesis [inference]

body morphogenesis [inference]

embryonic body morphogenesis

embryonic morphogenesis [inference]

embryonic body morphogenesis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

regulation of signaling receptor activity [inference]

regulation of cytokine activity

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

extracellular regulation of signal transduction [inference]

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

regulation of signaling receptor activity [inference]

regulation of cytokine activity

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

extracellular regulation of signal transduction [inference]

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

regulation of cellular response to growth factor stimulus [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

regulation of signaling receptor activity [inference]

regulation of cytokine activity

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

extracellular regulation of signal transduction [inference]

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

regulation of molecular function [inference]

regulation of signaling receptor activity [inference]

regulation of cytokine activity

regulation of binding [inference]

regulation of protein binding [inference]

regulation of receptor binding [inference]

regulation of cytokine activity

Displaying **all 2** entries
GO Term	Evidence Code	PMID
extracellular space	IMP	23063586
extracellular space	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

Displaying entries **1 - 5** of 7 in total

1

2

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GO Term	Evidence Code	PMID
cytokine activity	IEA
heparin binding	IDA	23850456
BMP binding	IMP	23063586
BMP binding	IBA
identical protein binding	IMP	23063586

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

receptor ligand activity

cytokine activity

cytokine binding [inference]

BMP binding

identical protein binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

cytokine activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

cytokine activity

Gene Ontology information from NCBI Gene and UniProt.

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026