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tumor necrosis factor (ligand) superfamily, member 13b

Summary

Gene Symbol

Tnfsf13b

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

24099

PubChem

24099

Alliance of Genome Resources

MGI:1344376

Annotation

Keyword

Alternative splicing
Cell membrane
Cleavage on pair of basic residues
Cytokine
Disulfide bond
Glycoprotein
Reference proteome
Secreted
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 4** entries
UniProt	Protein Name
Q3KP92
Q9WU72	B-cell-activating factor BAFF
Q8BVA3
A0A0U5J6R6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
B cell homeostasis	IMP	14557413
cytokine production	IDA	17581616
cytokine production	IMP	17581616
transitional one stage B cell differentiation	IMP	17581616
immunoglobulin production	IMP	17581616

GO Hierarchy

biological process

immune system process [inference]

leukocyte homeostasis [inference]

lymphocyte homeostasis [inference]

B cell homeostasis

production of molecular mediator of immune response [inference]

immunoglobulin production

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

germinal center formation

lymphocyte costimulation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation

immature B cell differentiation [inference]

transitional stage B cell differentiation [inference]

transitional one stage B cell differentiation

T cell activation [inference]

T cell proliferation

B cell activation [inference]

B cell differentiation

immature B cell differentiation [inference]

transitional stage B cell differentiation [inference]

transitional one stage B cell differentiation

B cell proliferation

lymphocyte proliferation [inference]

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production

production of molecular mediator of immune response [inference]

immunoglobulin production

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production

production of molecular mediator of immune response [inference]

immunoglobulin production

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production

production of molecular mediator of immune response [inference]

immunoglobulin production

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production

production of molecular mediator of immune response [inference]

immunoglobulin production

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production

production of molecular mediator of immune response [inference]

immunoglobulin production

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation

immature B cell differentiation [inference]

transitional stage B cell differentiation [inference]

transitional one stage B cell differentiation

T cell activation [inference]

T cell proliferation

B cell activation [inference]

B cell differentiation

immature B cell differentiation [inference]

transitional stage B cell differentiation [inference]

transitional one stage B cell differentiation

B cell proliferation

lymphocyte proliferation [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

tumor necrosis factor-mediated signaling pathway

cell population proliferation [inference]

leukocyte proliferation [inference]

mononuclear cell proliferation [inference]

lymphocyte proliferation [inference]

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production

production of molecular mediator of immune response [inference]

immunoglobulin production

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation

immature B cell differentiation [inference]

transitional stage B cell differentiation [inference]

transitional one stage B cell differentiation

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation

immature B cell differentiation [inference]

transitional stage B cell differentiation [inference]

transitional one stage B cell differentiation

T cell activation [inference]

T cell proliferation

B cell activation [inference]

B cell differentiation

immature B cell differentiation [inference]

transitional stage B cell differentiation [inference]

transitional one stage B cell differentiation

B cell proliferation

lymphocyte proliferation [inference]

cytokine production

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

leukocyte homeostasis [inference]

lymphocyte homeostasis [inference]

B cell homeostasis

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

germinal center formation

anatomical structure development [inference]

animal organ development [inference]

skin development

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation

immature B cell differentiation [inference]

transitional stage B cell differentiation [inference]

transitional one stage B cell differentiation

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

leukocyte homeostasis [inference]

lymphocyte homeostasis [inference]

B cell homeostasis

response to stimulus [inference]

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

germinal center formation

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell activation [inference]

positive regulation of B cell activation [inference]

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of germinal center formation

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell activation [inference]

positive regulation of B cell activation [inference]

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

regulation of B cell proliferation [inference]

positive regulation of B cell proliferation

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of lymphocyte proliferation [inference]

regulation of T cell activation [inference]

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation [inference]

regulation of B cell activation [inference]

regulation of B cell proliferation [inference]

positive regulation of B cell proliferation

positive regulation of B cell activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell activation [inference]

positive regulation of B cell activation [inference]

regulation of immune response

regulation of adaptive immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of germinal center formation

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of germinal center formation [inference]

positive regulation of germinal center formation

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of germinal center formation

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of germinal center formation

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell activation [inference]

positive regulation of B cell activation [inference]

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of germinal center formation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell activation [inference]

positive regulation of B cell activation [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of germinal center formation

positive regulation of developmental process [inference]

positive regulation of germinal center formation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell activation [inference]

positive regulation of B cell activation [inference]

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of germinal center formation

regulation of immune response

regulation of adaptive immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of germinal center formation

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of germinal center formation [inference]

positive regulation of germinal center formation

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of germinal center formation

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of germinal center formation

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of germinal center formation [inference]

positive regulation of germinal center formation

positive regulation of developmental process [inference]

positive regulation of germinal center formation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

tumor necrosis factor-mediated signaling pathway

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

regulation of leukocyte proliferation [inference]

regulation of mononuclear cell proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

regulation of lymphocyte proliferation [inference]

regulation of B cell proliferation [inference]

positive regulation of B cell proliferation

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell activation [inference]

positive regulation of B cell activation [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell activation [inference]

positive regulation of B cell activation [inference]

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

regulation of B cell proliferation [inference]

positive regulation of B cell proliferation

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of lymphocyte proliferation [inference]

regulation of T cell activation [inference]

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation [inference]

regulation of B cell activation [inference]

regulation of B cell proliferation [inference]

positive regulation of B cell proliferation

positive regulation of B cell activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell activation [inference]

positive regulation of B cell activation [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell activation [inference]

positive regulation of B cell activation [inference]

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell activation [inference]

positive regulation of B cell activation [inference]

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

regulation of B cell proliferation [inference]

positive regulation of B cell proliferation

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of lymphocyte proliferation [inference]

regulation of T cell activation [inference]

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation [inference]

regulation of B cell activation [inference]

regulation of B cell proliferation [inference]

positive regulation of B cell proliferation

positive regulation of B cell activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell activation [inference]

positive regulation of B cell activation [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell activation [inference]

positive regulation of B cell activation [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell activation [inference]

positive regulation of B cell activation [inference]

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
extracellular space	IBA
extracellular space	IEA
cytoplasm	ISO
plasma membrane	ISO
plasma membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

perinuclear region of cytoplasm

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytokine activity	IEA
tumor necrosis factor receptor binding	IEA
receptor ligand activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

cytokine receptor binding [inference]

tumor necrosis factor receptor superfamily binding [inference]

tumor necrosis factor receptor binding

receptor ligand activity

cytokine activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

cytokine activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

cytokine activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

tumor necrosis factor ligand superfamily

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
immune response
positive regulation of B cell proliferation
tumor necrosis factor receptor binding

Displaying **all 2** entries
InterPro
Tumour necrosis factor domain
Tumour necrosis factor-like domain superfamily

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:12894	Sjogren's syndrome	Alliance of Genome Resources
DOID:2986	IgA glomerulonephritis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 54 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	10673	ZFIN:ZDB-GENE-080204-44	HUMAN17615
Danio rerio	24099	ZFIN:ZDB-GENE-080204-44
Pan troglodytes	467323		PANTR08065
Rattus norvegicus	498666		RATNO11590
Bos taurus	504507		BOVIN04111
Danio rerio	561268		DANRE45483
Macaca mulatta	693917		MACMU16586
Monodelphis domestica	100024583		MONDO32021
Sus scrofa	100038026		PIGXX01521
Oryctolagus cuniculus	100101577		RABIT12578

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements