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crumbs family member 2

Summary

Gene Symbol

Crb2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

241324

PubChem

241324

Alliance of Genome Resources

MGI:2679260

Annotation

Keyword

Calcium
Cell membrane
Disulfide bond
EGF-like domain
Gastrulation
Glycoprotein
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q80YA8	Crumbs-like protein 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 16 in total

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GO Term	Evidence Code	PMID
positive regulation of epithelial to mesenchymal transition	IMP	22072575 27870829
negative regulation of endopeptidase activity	ISO
notochord formation	IMP	22072575
establishment of cell polarity	IMP	23001562
positive regulation of BMP signaling pathway	IMP	22072575

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion [inference]

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

establishment or maintenance of cell polarity [inference]

establishment of cell polarity

maintenance of cell polarity [inference]

maintenance of apical/basal cell polarity [inference]

maintenance of epithelial cell apical/basal polarity

establishment or maintenance of bipolar cell polarity [inference]

establishment or maintenance of apical/basal cell polarity [inference]

maintenance of apical/basal cell polarity [inference]

maintenance of epithelial cell apical/basal polarity

establishment or maintenance of epithelial cell apical/basal polarity

maintenance of epithelial cell apical/basal polarity

cellular developmental process [inference]

cell development [inference]

neuron development [inference]

photoreceptor cell development [inference]

eye photoreceptor cell development [inference]

retinal cone cell development

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

cell migration involved in gastrulation [inference]

ingression involved in gastrulation with mouth forming second

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

anterior/posterior pattern specification [inference]

somitogenesis

segmentation [inference]

somitogenesis

photoreceptor cell maintenance

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

retina homeostasis

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

formation of primary germ layer [inference]

mesoderm formation

anatomical structure development [inference]

cell development [inference]

neuron development [inference]

photoreceptor cell development [inference]

eye photoreceptor cell development [inference]

retinal cone cell development

system development [inference]

circulatory system development

cellular developmental process [inference]

cell development [inference]

neuron development [inference]

photoreceptor cell development [inference]

eye photoreceptor cell development [inference]

retinal cone cell development

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

retina homeostasis

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of cell differentiation [inference]

positive regulation of epithelial to mesenchymal transition

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of epithelial to mesenchymal transition

positive regulation of multicellular organismal process [inference]

positive regulation of epithelial to mesenchymal transition

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of cellular response to growth factor stimulus [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of gastrulation

regulation of cell differentiation [inference]

regulation of epithelial to mesenchymal transition [inference]

positive regulation of epithelial to mesenchymal transition

positive regulation of cell differentiation [inference]

positive regulation of epithelial to mesenchymal transition

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of epithelial to mesenchymal transition

regulation of multicellular organismal development [inference]

regulation of embryonic development [inference]

regulation of gastrulation

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of cell differentiation [inference]

regulation of epithelial to mesenchymal transition [inference]

positive regulation of epithelial to mesenchymal transition

positive regulation of cell differentiation [inference]

positive regulation of epithelial to mesenchymal transition

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of cell differentiation [inference]

positive regulation of epithelial to mesenchymal transition

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of epithelial to mesenchymal transition

regulation of multicellular organismal development [inference]

regulation of embryonic development [inference]

regulation of gastrulation

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
cytoplasm	IDA	26404741
plasma membrane	IBA
apical plasma membrane	IDA	17920587 20399730 26496195 27870829
apicolateral plasma membrane	IDA	26404741
cell junction	IDA	26404741

GO Hierarchy

cellular component

protein-containing complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

subapical complex

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

plasma membrane region [inference]

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
calcium ion binding	IEA
protein binding	IPI	20399730 26496195
aspartic-type endopeptidase inhibitor activity	ISO
aspartic-type endopeptidase inhibitor activity	IEA
protein-containing complex binding	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein-containing complex binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

aspartic-type endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

aspartic-type endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity [inference]

aspartic-type endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

aspartic-type endopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

protein crumbs homolog 2

Functional Category

D: Cell cycle control, cell division, chromosome partitioning
J: Translation, ribosomal structure and biogenesis
L: Replication, recombination and repair
M: Cell wall/membrane/envelope biogenesis

Displaying 1 entry
Gene Ontology
calcium ion binding

Displaying **all 7** entries
InterPro
Concanavalin A-like lectin/glucanase domain superfamily
EGF-like calcium-binding domain
EGF-like calcium-binding, conserved site
EGF-like domain
EGF-like, conserved site
EGF-type aspartate/asparagine hydroxylation site
Laminin G domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:10584	retinitis pigmentosa	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 74 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	23418	FB:FBgn0259685
Xenopus tropicalis	42896	Xenbase:XB-GENE-989701
Drosophila melanogaster	170788	FB:FBgn0259685
Xenopus tropicalis	241324	Xenbase:XB-GENE-989701
Homo sapiens	286204	Xenbase:XB-GENE-989701	HUMAN98346
Rattus norvegicus	366031		RATNO26809
Pan troglodytes	473056		PANTR44780
Macaca mulatta	695065		MACMU12462
Danio rerio	723994		DANRE21229
Bos taurus	786516		BOVIN03108

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements