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Guidelines

MIRAGE

LMBR1 domain containing 1

Summary

Gene Symbol

Lmbrd1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

246046

PubChem

246046

Alliance of Genome Resources

RGD:708471

Annotation

Keyword

Cell membrane
Cobalamin
Cytoplasmic vesicle
Endocytosis
Endoplasmic reticulum
Gastrulation
Glycoprotein
Lysosome
Phosphoprotein
Reference proteome
Transmembrane helix
Transport

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6JJC1	LMBR1 domain-containing protein 1
Q6AZ61	LMBR1 domain-containing protein 1

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
gastrulation	ISS
gastrulation	ISO
gastrulation	IEA
insulin receptor internalization	ISS
insulin receptor internalization	ISO

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization [inference]

insulin receptor internalization

clathrin-dependent endocytosis

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to vacuole [inference]

protein localization to lysosome

developmental process [inference]

anatomical structure morphogenesis [inference]

embryonic morphogenesis [inference]

gastrulation

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to vacuole [inference]

protein localization to lysosome

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization [inference]

insulin receptor internalization

clathrin-dependent endocytosis

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization [inference]

insulin receptor internalization

clathrin-dependent endocytosis

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to vacuole [inference]

protein localization to lysosome

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
lysosome	ISO
lysosomal membrane	ISS
lysosomal membrane	ISO
lysosomal membrane	IBA
lysosomal membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

intracellular membrane-bounded organelle

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
insulin receptor binding	ISO
cobalamin binding	IEA
clathrin heavy chain binding	ISS
clathrin heavy chain binding	ISO
AP-2 adaptor complex binding	ISS

GO Hierarchy

molecular function

transporter activity [inference]

protein transporter activity

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

insulin receptor binding

clathrin binding [inference]

clathrin heavy chain binding

small molecule binding [inference]

vitamin binding [inference]

cobalamin binding

heterocyclic compound binding [inference]

cobalamin binding

protein-containing complex binding [inference]

AP-2 adaptor complex binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

cobalamin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

lysosomal cobalamin transporter

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
cobalamin binding
protein localization to lysosome

Displaying 1 entry
InterPro
LMBR1-like membrane protein

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	55788	Xenbase:XB-GENE-1015707	HUMAN85370
Mus musculus	68421	Xenbase:XB-GENE-1015707	MOUSE28545
Xenopus tropicalis	246046	Xenbase:XB-GENE-1015707
Danio rerio	323720	Xenbase:XB-GENE-1015707	DANRE05804
Xenopus tropicalis	398468	Xenbase:XB-GENE-1015707
Bos taurus	510495		BOVIN35299
Macaca mulatta	714710		MACMU34877
Pan troglodytes	736319		PANTR38489
Xenopus tropicalis	779630	Xenbase:XB-GENE-1015707
Monodelphis domestica	100020591		MONDO13459

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025