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CD8 subunit alpha

Summary

Gene Symbol

Cd8a

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

24930

PubChem

24930

Alliance of Genome Resources

RGD:2316

Annotation

Keyword

Adaptive immunity
Cell membrane
Disulfide bond
Glycoprotein
Immunoglobulin domain
Palmitate
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6IA73
P07725	CD8 antigen 32 kDa chain OX-8 membrane antigen

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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2

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GO Term	Evidence Code	PMID
cytotoxic T cell differentiation	IBA ISO
T cell receptor signaling pathway	ISO
response to methamphetamine hydrochloride	IEP	25678251
calcium-mediated signaling	ISO
cell surface receptor signaling pathway	IBA ISO

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte mediated immunity [inference]

lymphocyte mediated immunity [inference]

T cell mediated immunity

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

T cell mediated immunity

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

cytotoxic T cell differentiation

T cell activation

T cell differentiation [inference]

cytotoxic T cell differentiation

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

cytotoxic T cell differentiation

T cell activation

T cell differentiation [inference]

cytotoxic T cell differentiation

signal transduction [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

cell surface receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

cytotoxic T cell differentiation

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

cytotoxic T cell differentiation

T cell activation

T cell differentiation [inference]

cytotoxic T cell differentiation

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

cytotoxic T cell differentiation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

T cell mediated immunity

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to amine [inference]

response to methamphetamine hydrochloride

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to amine [inference]

response to methamphetamine hydrochloride

response to salt [inference]

response to methamphetamine hydrochloride

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling [inference]

positive regulation of calcium-mediated signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling [inference]

positive regulation of calcium-mediated signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

cell surface receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling [inference]

positive regulation of calcium-mediated signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

Displaying **all 5** entries
GO Term	Evidence Code	PMID
external side of plasma membrane	IBA ISO
plasma membrane raft	ISO
receptor complex	ISO
plasma membrane	ISO
cell surface	IDA ISO	11734593 15474526 17436231 18292522 19022963

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

cell surface

membrane [inference]

plasma membrane

plasma membrane region [inference]

plasma membrane raft

membrane microdomain [inference]

membrane raft [inference]

plasma membrane raft

side of membrane [inference]

external side of plasma membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
identical protein binding	ISO
protein kinase binding	IPI	1372996
MHC class I protein complex binding	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

identical protein binding

protein-containing complex binding [inference]

MHC protein complex binding [inference]

MHC class I protein complex binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

T-cell surface glycoprotein CD8 alpha chain

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
T cell mediated immunity
cell surface receptor signaling pathway
cytotoxic T cell differentiation

Displaying **all 6** entries
InterPro
CD8 alpha subunit
Immunoglobulin V-set domain
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
cell surface	PMID:11734593 PMID:15474526 PMID:17436231 PMID:18292522 PMID:19022963

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:0050185	erythema multiforme	Alliance of Genome Resources
DOID:0080600	COVID-19	Alliance of Genome Resources
DOID:10534	stomach cancer	Alliance of Genome Resources
DOID:3454	brain infarction	Alliance of Genome Resources
DOID:612	primary immunodeficiency disease	Alliance of Genome Resources
DOID:635	acquired immunodeficiency syndrome	Alliance of Genome Resources
DOID:670	amphetamine abuse	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 66 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Microtus ochrogaster	102000935	79684_0:001e8d
Chinchilla lanigera	102014798	34839_0:001819	CHILA07593
Capra hircus	102185010		CAPHI01887
Peromyscus maniculatus bairdii	102920047	230844_0:0010bf
Ornithorhynchus anatinus	103171162		ORNAN09706
Chlorocebus sabaeus	103241361		CHLSB04123
Ursus maritimus	103671471		URSMA00516
Nannospalax galili	103737047	1026970_0:001e0e
Fukomys damarensis	104863282	885580_0:00019f
Pteropus vampyrus	105302299		PTEVA07059

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements