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Guidelines
MIRAGE
proprotein convertase subtilisin/kexin type 2

Summary
Gene Symbol
  • Pcsk2
Organism
Rattus norvegicus (Norway rat)
NCBI Gene
25121
PubChem
25121
Alliance of Genome Resources
Annotation
Keyword
  • Cleavage on pair of basic residues
  • Coiled coil
  • Cytoplasmic vesicle
  • Disulfide bond
  • Glycoprotein
  • Reference proteome
  • Secreted
  • Serine protease
  • Signal
  • Zymogen
Proteins
Displaying all 2 entries
UniProt Protein Name
P28841
  • KEX2-like endoprotease 2
  • Prohormone convertase 2
  • Proprotein convertase 2
A6K734
Annotation information from UniProt.
Gene Ontology (GO)
Displaying entries 1 - 5 of 13 in total
GO Term Evidence Code PMID
proteolysis
nervous system development
protein processing
protein processing
peptide hormone processing
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Eukaryota
Group Name
proprotein convertase subtilisin/kexin type
Functional Category
  • E: Amino acid transport and metabolism
  • O: Posttranslational modification, protein turnover, chaperones
  • T: Signal transduction mechanisms
Displaying all 5 entries
Gene Ontology
hydrolase activity
peptide hormone processing
proteolysis
serine-type endopeptidase activity
serine-type peptidase activity
Displaying entries 1 - 10 of 11 in total
InterPro
Galactose-binding-like domain superfamily
Kexin/furin catalytic domain
P domain
Peptidase S8, pro-domain superfamily
Peptidase S8, pro-domain
Peptidase S8, subtilisin, Asp-active site
Peptidase S8, subtilisin, His-active site
Peptidase S8, subtilisin, Ser-active site
Peptidase S8, subtilisin-related
Peptidase S8/S53 domain superfamily
Alliance of Genome Resources
Expression
Displaying all 3 entries
Location References
Disease
Disease Ontology
Displaying 1 entry
DO ID Disease Name Source
DOID:784 chronic kidney disease
Ortholog
Displaying entries 71 - 78 of 78 in total
Species Gene ID Alliance of Genome Resources Orthologous MAtrix
115399016 SALFA53909
115560303 GADMO15374
115609680 STRHB17565
116441566 CORMO17112
116840008 CHEAB19185
117016129 RHIFE23329
118881888 BALMU20831
122215838 PANLE01614
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025