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glycine N-methyltransferase

Summary

Gene Symbol

Gnmt

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

25134

PubChem

25134

Alliance of Genome Resources

RGD:2719

Annotation

Keyword

3D-structure
Acetylation
Cytoplasm
Direct protein sequencing
Folate-binding
Methyltransferase
Phosphoprotein
Reference proteome
S-adenosyl-L-methionine

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6JIM7
P13255	Folate-binding protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
S-adenosylhomocysteine metabolic process	IBA IDA IMP	10756111 15347642
glycine metabolic process	IMP	10756111 18501206
glycogen metabolic process	ISO
S-adenosylmethionine metabolic process	IBA IDA IEA IMP ISO	10756111 12054489 15340920 18501206
sarcosine metabolic process	IBA IMP	18501206

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

organonitrogen compound metabolic process [inference]

sulfur amino acid metabolic process [inference]

methionine metabolic process

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

methionine metabolic process

serine family amino acid metabolic process [inference]

glycine metabolic process

cellular modified amino acid metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

methylation

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

sulfur amino acid metabolic process [inference]

methionine metabolic process

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

methionine metabolic process

serine family amino acid metabolic process [inference]

glycine metabolic process

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process [inference]

glycogen metabolic process

cellular modified amino acid metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

one-carbon metabolic process

sulfur compound metabolic process [inference]

sulfur amino acid metabolic process [inference]

methionine metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

glucan metabolic process [inference]

glycogen metabolic process

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

methionine metabolic process

serine family amino acid metabolic process [inference]

glycine metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

sulfur amino acid metabolic process [inference]

methionine metabolic process

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

methionine metabolic process

serine family amino acid metabolic process [inference]

glycine metabolic process

one-carbon metabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

glucan metabolic process [inference]

glycogen metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

sulfur amino acid metabolic process [inference]

methionine metabolic process

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

methionine metabolic process

serine family amino acid metabolic process [inference]

glycine metabolic process

macromolecule metabolic process [inference]

polysaccharide metabolic process [inference]

glucan metabolic process [inference]

glycogen metabolic process

S-adenosylmethionine metabolic process

carbohydrate derivative metabolic process [inference]

glycosyl compound metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

organonitrogen compound metabolic process [inference]

sulfur amino acid metabolic process [inference]

methionine metabolic process

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

methionine metabolic process

serine family amino acid metabolic process [inference]

glycine metabolic process

cellular modified amino acid metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

sulfur amino acid metabolic process [inference]

methionine metabolic process

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

methionine metabolic process

serine family amino acid metabolic process [inference]

glycine metabolic process

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process [inference]

glycogen metabolic process

cellular modified amino acid metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

one-carbon metabolic process

sulfur compound metabolic process [inference]

sulfur amino acid metabolic process [inference]

methionine metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of carbohydrate biosynthetic process [inference]

regulation of gluconeogenesis

regulation of small molecule metabolic process [inference]

regulation of glucose metabolic process [inference]

regulation of gluconeogenesis

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

regulation of glucose metabolic process [inference]

regulation of gluconeogenesis

regulation of carbohydrate biosynthetic process [inference]

regulation of gluconeogenesis

Displaying **all 2** entries
GO Term	Evidence Code	PMID
methyltransferase complex	IMP	10756111
cytosol	IBA IDA IEA ISO TAS	6587377

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

transferase complex [inference]

methyltransferase complex

cellular anatomical entity [inference]

cytosol

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
glycine binding	IBA IDA IEA IMP ISO TAS	10756111 15340920 15347642
selenol Se-methyltransferase activity	TAS
glycine N-methyltransferase activity	IBA IDA IEA IMP ISO	10756111 12054489 15340920 18501206
S-adenosyl-L-methionine binding	IBA IMP	10756111
identical protein binding	IBA IEA IPI ISO	10756111 17158459

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring one-carbon groups [inference]

methyltransferase activity [inference]

N-methyltransferase activity [inference]

glycine N-methyltransferase activity

S-adenosylmethionine-dependent methyltransferase activity

glycine N-methyltransferase activity

selenol Se-methyltransferase activity

binding [inference]

protein binding [inference]

identical protein binding

amide binding [inference]

folic acid binding

small molecule binding [inference]

vitamin binding [inference]

folic acid binding

organic acid binding [inference]

carboxylic acid binding [inference]

folic acid binding

amino acid binding [inference]

glycine binding

heterocyclic compound binding [inference]

folic acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

folic acid binding

amino acid binding [inference]

glycine binding

cation binding [inference]

modified amino acid binding [inference]

folic acid binding

organic cyclic compound binding [inference]

folic acid binding

sulfur compound binding [inference]

S-adenosyl-L-methionine binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

glycine N-methyltransferase

Functional Category

H: Coenzyme transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 10** entries
Gene Ontology
S-adenosylhomocysteine metabolic process
S-adenosylmethionine metabolic process
folic acid binding
glycine N-methyltransferase activity
glycine binding
identical protein binding
methylation
protein homotetramerization
sarcosine metabolic process
transferase activity

Displaying **all 2** entries
InterPro
Glycine/Sarcosine N-methyltransferase
S-adenosyl-L-methionine-dependent methyltransferase superfamily

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0111037	glycine N-methyltransferase deficiency	Alliance of Genome Resources
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **113** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	14711	10090_1:004be5	MGI:1202304	MOUSE22546
Homo sapiens	27232		HGNC:4415	HUMAN84831
Drosophila melanogaster	41561		FB:FBgn0038074
Sus scrofa	397444			PIGXX31581
Danio rerio	403338		ZFIN:ZDB-GENE-040227-1	DANRE13235
Pan troglodytes	462703			PANTR38185
Bos taurus	538212			BOVIN18514
Macaca mulatta	697722			MACMU34778
Oryctolagus cuniculus	100009512			RABIT02444
Monodelphis domestica	100010632			MONDO13234

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External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements