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syndecan 1

Summary

Gene Symbol

Sdc1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

25216

PubChem

25216

Alliance of Genome Resources

RGD:3648

Annotation

Keyword

Heparan sulfate
Phosphoprotein
Reference proteome
Secreted
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6HAM5
P26260

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 15** of 16 in total

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GO Term	Evidence Code	PMID
response to cAMP	IEP	12135485
cell-cell signaling	NAS	12135485
cell adhesion	NAS	12135485
ureteric bud development	IEP	15282150
positive regulation of exosomal secretion	ISO

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling

cell adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

canonical Wnt signaling pathway

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

Sertoli cell development

myoblast development

muscle cell development [inference]

striated muscle cell development

cell motility [inference]

cell migration

reproductive process [inference]

developmental process involved in reproduction [inference]

Sertoli cell development

developmental process [inference]

developmental process involved in reproduction [inference]

Sertoli cell development

anatomical structure development [inference]

tissue development [inference]

epithelium development [inference]

kidney epithelium development [inference]

mesonephric epithelium development [inference]

mesonephric tubule development [inference]

ureteric bud development

tube development [inference]

mesonephric tubule development [inference]

ureteric bud development

cell development [inference]

epithelial cell development [inference]

Sertoli cell development

myoblast development

muscle cell development [inference]

striated muscle cell development

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

Sertoli cell development

myoblast development

muscle cell development [inference]

striated muscle cell development

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

response to reactive oxygen species [inference]

response to hydrogen peroxide

response to endogenous stimulus [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to chemical [inference]

response to toxic substance

response to organic substance [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP

response to organic cyclic compound [inference]

response to purine-containing compound [inference]

response to cAMP

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to lipid [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to hydrogen peroxide

response to organophosphorus [inference]

response to cAMP

response to calcium ion

response to inorganic substance [inference]

response to metal ion [inference]

response to calcium ion

response to hydrogen peroxide

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP

response to oxygen-containing compound [inference]

response to reactive oxygen species [inference]

response to hydrogen peroxide

response to salt [inference]

response to calcium ion

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

regulation of exosomal secretion [inference]

positive regulation of exosomal secretion

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

regulation of exosomal secretion [inference]

positive regulation of exosomal secretion

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of organelle assembly [inference]

positive regulation of extracellular exosome assembly

positive regulation of exosomal secretion

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of organelle assembly [inference]

positive regulation of extracellular exosome assembly

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

canonical Wnt signaling pathway

regulation of cellular component biogenesis [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of organelle assembly [inference]

positive regulation of extracellular exosome assembly

positive regulation of exosomal secretion

regulation of organelle assembly [inference]

positive regulation of organelle assembly [inference]

positive regulation of extracellular exosome assembly

regulation of extracellular exosome assembly [inference]

positive regulation of extracellular exosome assembly

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of organelle assembly [inference]

positive regulation of extracellular exosome assembly

positive regulation of exosomal secretion

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of organelle assembly [inference]

positive regulation of extracellular exosome assembly

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of organelle assembly [inference]

positive regulation of extracellular exosome assembly

regulation of organelle assembly [inference]

positive regulation of organelle assembly [inference]

positive regulation of extracellular exosome assembly

regulation of extracellular exosome assembly [inference]

positive regulation of extracellular exosome assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of organelle assembly [inference]

positive regulation of extracellular exosome assembly

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

regulation of exosomal secretion [inference]

positive regulation of exosomal secretion

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

regulation of exosomal secretion [inference]

positive regulation of exosomal secretion

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

Displaying **all 5** entries
GO Term	Evidence Code	PMID
external side of plasma membrane	ISO
protein-containing complex	IDA	11431373
plasma membrane	ISO
extracellular region	IEA
cell surface	IBA ISO

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

side of membrane [inference]

external side of plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	11431373 26601939 9089390
extracellular matrix binding	TAS	12135485
identical protein binding	ISO
cargo receptor activity	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding

identical protein binding

extracellular matrix binding

cargo receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

Syndecan

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
cell migration

Displaying **all 4** entries
InterPro
Neurexin/syndecan/glycophorin C
Syndecan, conserved site
Syndecan/Neurexin domain
Syndecan

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
protein-containing complex	PMID:11431373

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:1168	familial hyperlipidemia	Alliance of Genome Resources
DOID:3910	lung adenocarcinoma	Alliance of Genome Resources
DOID:4195	hyperglycemia	Alliance of Genome Resources
DOID:576	proteinuria	Alliance of Genome Resources
DOID:5844	myocardial infarction	Alliance of Genome Resources
DOID:8567	Hodgkin's lymphoma	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 75 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Octodon degus	101583977	10160_0:000dd4	OCTDE04330
Jaculus jaculus	101601644	51337_0:001e39
Heterocephalus glaber	101723528	10181_0:0009e6
Mesocricetus auratus	101836998	10036_0:0039a3
Ictidomys tridecemlineatus	101966983	43179_0:003860
Microtus ochrogaster	101996152	79684_0:003060
Chinchilla lanigera	102012750	34839_0:003345
Capra hircus	102185011		CAPHI02218
Peromyscus maniculatus bairdii	102911819	230844_0:004c6e
Chlorocebus sabaeus	103220724		CHLSB04513